Downregulation of triggering receptor expressed on myeloid cells 1 inhibits invasion and migration of liver cancer cells by mediating macrophage polarization

2021 ◽  
Vol 45 (4) ◽  
Author(s):  
Minmin Chen ◽  
Ruimin Lai ◽  
Xiaoyu Lin ◽  
Wei Chen ◽  
Huizhen Wu ◽  
...  
Keyword(s):  
Liver Cancer ◽  
Cancer Cells ◽  
Macrophage Polarization ◽  
Myeloid Cells ◽  
Invasion And Migration ◽  
Liver Cancer Cells ◽  
And Migration

scholarly journals Expression of CHODL in hepatocellular carcinoma affects invasion and migration of liver cancer cells

2016 ◽  
Vol 13 (2) ◽  
pp. 715-721 ◽  
Author(s):  
Zejian Huang ◽  
Ning Zhang ◽  
Wenda Li ◽  
Jun Cao ◽  
Lei Zhang ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Liver Cancer ◽  
Cancer Cells ◽  
Invasion And Migration ◽  
Liver Cancer Cells ◽  
And Migration

Silencing of WWP2 inhibits adhesion, invasion, and migration in liver cancer cells

Tumor Biology ◽  
2015 ◽  
Vol 37 (5) ◽  
pp. 6787-6799 ◽  
Author(s):  
Yong Qin ◽  
Sheng-qian Xu ◽  
De-biao Pan ◽  
Guan-xiong Ye ◽  
Cheng-jun Wu ◽  
...  
Keyword(s):  
Liver Cancer ◽  
Cancer Cells ◽  
Invasion And Migration ◽  
Liver Cancer Cells ◽  
And Migration

scholarly journals β-carotene Suppresses Colon Cancer by Regulating M2 Macrophages and Tumor-associated Fibroblasts in Vitro and in Vivo (P02-015-19)

2019 ◽  
Vol 3 (Supplement_1) ◽  
Author(s):  
Yerin Kim ◽  
Na Youn Lee ◽  
Yoo Sun Kim ◽  
Yuri Kim
Keyword(s):  
Colon Cancer ◽  
Cancer Cells ◽  
Macrophage Polarization ◽  
M2 Macrophage ◽  
Invasion And Migration ◽  
And Migration ◽  
Emt Markers ◽  
Β Carotene

Abstract Objectives Tumor-associated macrophages (TAMs) and tumor-associated fibroblasts (TAFs) are consisted of tumor microenvironment (TME), which are involved in cancer progression and metastasis. Interactions within TME induce M2 macrophage phenotype, TAMs, and activate TAFs. β-carotene (BC) is a well-known antioxidant and showed protective effects on several diseases, including cancers. The object of this study is to investigate the anti-colorectal cancer (CRC) effects of BC by controlling macrophage polarization and fibroblast activation. Methods TAMs were induced by treating with phorbol-12-myristate-13-acetate (PMA) and interleukin-4 (IL-4) in U937 cells and TAFs were induced by treating with transforming growth factor-β1 (TGF-β1) in CCD-18Co cells. To understand the effect of TME on cancer cells, HCT116 colon cancer cells were co-cultured with TAM or TAF conditioned media. The effects of BC on the expressions of cancer stem cells (CSCs) markers, epithelial-mesenchymal transition (EMT) markers along with invasion and migration were investigated. To confirm these results, the azoxymethane (AOM) and dextran sodium sulfate (DSS)-induced colitis-associated CRC mice model was used. Results BC decreased M2 macrophage polarization with activating IL-6/STAT3 signaling pathways and suppressed the expressions of fibroblast activation markers and EMT markers. In addition, BC inhibited the expressions of TME-induced CSCs markers and EMT and suppressed cell invasion and migration. Furthermore, BC supplementation suppressed tumorigenesis and the expressions of M2 macrophage-associated markers, including CD206, Arg1, and Ym-1 as well as CSCs markers in vivo. Conclusions BC suppressed CRC by regulating TAMs and TAFs in vitro and in vivo, which indicated the potential therapeutic effects of BC on inflammatory diseases. Funding Sources This research was supported by Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education and Brain Korea 21 Plus.

Nuclear expression of the ubiquitin ligase seven in absentia homolog (SIAH)-1 induces proliferation and migration of liver cancer cells

2011 ◽  
Vol 55 (5) ◽  
pp. 1049-1057 ◽  
Author(s):  
Antje Brauckhoff ◽  
Mona Malz ◽  
Darjus Tschaharganeh ◽  
Nisar Malek ◽  
Achim Weber ◽  
...  
Keyword(s):  
Liver Cancer ◽  
Cancer Cells ◽  
Ubiquitin Ligase ◽  
Liver Cancer Cells ◽  
Nuclear Expression ◽  
Seven In Absentia ◽  
And Migration ◽  
Proliferation And Migration

scholarly journals LDB2 inhibits proliferation and migration in liver cancer cells by abrogating HEY1 expression

Oncotarget ◽  
2017 ◽  
Vol 8 (55) ◽  
pp. 94440-94449 ◽  
Author(s):  
Hongyang Yu ◽  
Ruichun Jia ◽  
Ling Zhao ◽  
Shigang Song ◽  
Jing Gu ◽  
...  
Keyword(s):  
Liver Cancer ◽  
Cancer Cells ◽  
Liver Cancer Cells ◽  
And Migration ◽  
Proliferation And Migration

Overexpression of far upstream element binding proteins: A mechanism regulating proliferation and migration in liver cancer cells

Hepatology ◽  
2009 ◽  
Vol 50 (4) ◽  
pp. 1130-1139 ◽  
Author(s):  
Mona Malz ◽  
Achim Weber ◽  
Stephan Singer ◽  
Vera Riehmer ◽  
Michaela Bissinger ◽  
...  
Keyword(s):  
Liver Cancer ◽  
Cancer Cells ◽  
Binding Proteins ◽  
Liver Cancer Cells ◽  
Upstream Element ◽  
And Migration ◽  
Proliferation And Migration

scholarly journals Effects of propofol on the proliferation and migration of liver cancer cells

2021 ◽  
Vol 22 (1) ◽  
Author(s):  
Chan Li ◽  
Qingxia Fu ◽  
Jin Cai ◽  
Hongxia Mei ◽  
Wangning Shangguan
Keyword(s):  
Liver Cancer ◽  
Cancer Cells ◽  
Liver Cancer Cells ◽  
And Migration ◽  
Proliferation And Migration
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