nm23 protein expression in renal cell tumors: the role of the cell type.

1998 ◽  
Author(s):  
A Ayhan ◽  
A Usubütün ◽  
H Ozen ◽  
W Yasui ◽  
E Tahara
Keyword(s):  
Protein Expression ◽  
Renal Cell ◽  
Cell Type ◽  
Renal Cell Tumors ◽  
Nm23 Protein

Cell type- and stage-specific changes in HOXA7 protein expression in human ovarian folliculogenesis: possible role of GDF-9

2006 ◽  
Vol 74 (1) ◽  
pp. 1-10 ◽  
Author(s):  
Takayo Ota ◽  
Kyung-Bok Choi ◽  
C. Blake Gilks ◽  
Peter C.K. Leung ◽  
Nelly Auersperg
Keyword(s):  
Protein Expression ◽  
Cell Type ◽  
Ovarian Folliculogenesis

Prognostic Value of nm23 Protein Expression in Renal Cell Carcinomas

Oncology ◽  
1998 ◽  
Vol 55 (4) ◽  
pp. 370-376 ◽  
Author(s):  
Yoshinori Nakagawa ◽  
Kenichi Tsumatani ◽  
Norio Kurumatani ◽  
Masaki Cho ◽  
Yoshiteru Kitahori ◽  
...  
Keyword(s):  
Protein Expression ◽  
Renal Cell ◽  
Prognostic Value ◽  
Renal Cell Carcinomas ◽  
Nm23 Protein

A Retrospective Study of Multicentric Bovine Renal Cell Tumors

1996 ◽  
Vol 33 (2) ◽  
pp. 133-141 ◽  
Author(s):  
L. C. Kelley ◽  
W. A. Crowell ◽  
M. Puette ◽  
K. A. Langheinrich ◽  
A. D. Self
Keyword(s):  
Renal Cell ◽  
Clear Cell ◽  
Cell Type ◽  
Corpora Amylacea ◽  
Kidney Tumors ◽  
Clear Cell Type ◽  
Renal Cell Tumors ◽  
Yellow Orange ◽  
Gross Lesions ◽  
Positive Immunoreactivity

Tissues from twenty mature cows with primary renal cell tumors were submitted over an 11-year period because of gross lesions detected during routine slaughter and inspection. Tumors visualized grossly were multiple and bilateral in seven cattle, multiple within one kidney in four cattle, and solitary in nine cattle. The tumors were primarily cortical, yellow-orange to tan, proliferative, well circumscribed, and extended above the capsular surface of the kidney. Tumors were microscopically multiple even when grossly described as solitary lesions, except in one cow. Twelve tumors (60%) were microscopically multiple in one kidney, seven tumors (35%) were multiple and bilateral, and only one cow (5%) exhibited extrarenal metastasis. Tumors from nineteen cows were composed of eosinophilic granular epithelial cells; tumors from one cow were clear cell type. Each tumor contained several histologic patterns. Corpora amylacea, proteinaceous secretions, and hemosiderin were characteristic findings in bovine renal cell carcinoma. All 20 cows with renal cell tumors exhibited positive immunoreactivity to uromodulin (Tamm-Horsfall protein).

scholarly journals Immune microenvironment in clear cell type renal cell carcinoma with loss of PBRM1 protein expression

2019 ◽  
Vol 30 ◽  
pp. vi93
Author(s):  
Yuji Miura ◽  
Takanobu Motoshima ◽  
Naoko Inoshita ◽  
Toshikazu Okaneya ◽  
Toshimi Takano ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Protein Expression ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Clear Cell ◽  
Cell Type ◽  
Immune Microenvironment ◽  
Clear Cell Type

TRIM44 promotes cell proliferation and migration by inhibiting FRK in renal cell carcinoma

2020 ◽  
Author(s):  
Lungwani Muungo
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Proliferation ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Lymphatic Invasion ◽  
Cancer Specific Survival ◽  
Candidate Target ◽  
Candidate Target Gene ◽  
And Migration

TRIM44 has oncogenic roles in various cancers. However, TRIM44 expression andits function in renal cell carcinoma (RCC) are still unknown. Here in this study, weinvestigated the clinical significance of TRIM44 and its biological function in RCC.TRIM44 overexpression was significantly associated with clinical M stage, histologictype (clear cell) and presence of lymphatic invasion (P = .047, P = .005, and P = .028,respectively). Moreover, TRIM44 overexpression was significantly associated withpoor prognosis in terms of cancer-specific survival (P = .019). Gain-of-function andloss-of-function studies using TRIM44 and siTRIM44 transfection showed thatTRIM44 promotes cell proliferation and cell migration in two RCC cell lines, Caki1and 769P. To further investigate the role of TRIM44 in RCC, we performed integratedmicroarray analysis in Caki1 and 769P cells and explored the data in the Oncominedatabase. Interestingly, FRK was identified as a promising candidate target gene ofTRIM44, which was downregulated in RCC compared with normal renal tissues. Wefound that cell proliferation was inhibited by TRIM44 knockdown and then recoveredby siFRK treatment. Taken together, the present study revealed the associationbetween high expression of TRIM44 and poor prognosis in

Beyond Promoter: The Role of Macrophage in Invasion and Progression of Renal Cell Carcinoma

2020 ◽  
Vol 15 (7) ◽  
pp. 588-596
Author(s):  
Haibao Zhang ◽  
Guodong Zhu
Keyword(s):  
Renal Cell Carcinoma ◽  
Tumor Microenvironment ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Cell Formation ◽  
Biological Behavior ◽  
Tumor Stem Cell ◽  
The Past ◽  
The Common

Renal cell carcinoma (RCC) is one of the common urologic neoplasms, and its incidence has been increasing over the past several decades; however, its pathogenesis is still unknown up to now. Recent studies have found that in addition to tumor cells, other cells in the tumor microenvironment also affect the biological behavior of the tumor. Among them, macrophages exist in a large amount in tumor microenvironment, and they are generally considered to play a key role in promoting tumorigenesis. Therefore, we summarized the recent researches on macrophage in the invasiveness and progression of RCC in latest years, and we also introduced and discussed many studies about macrophage in RCC to promote angiogenesis by changing tumor microenvironment and inhibit immune response in order to activate tumor progression. Moreover, macrophage interactes with various cytokines to promote tumor proliferation, invasion and metastasis, and it also promotes tumor stem cell formation and induces drug resistance in the progression of RCC. The highlight of this review is to make a summary of the roles of macrophage in the invasion and progression of RCC; at the same time to raise some potential and possible targets for future RCC therapy.

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