Validation of a Knowledge Transfer Tool for the Knee Inflammation MRI Scoring System for Bone Marrow Lesions According to the OMERACT Filter: Data from the Osteoarthritis Initiative

2017 ◽  
Vol 44 (11) ◽  
pp. 1718-1722 ◽  
Author(s):  
Jacob L. Jaremko ◽  
Omar Azmat ◽  
Robert G. Lambert ◽  
Paul Bird ◽  
Ida K. Haugen ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Scoring System ◽  
High Reliability ◽  
Intraclass Correlation ◽  
Average Score ◽  
Therapeutic Trial ◽  
Web Based ◽  
Bone Marrow Lesions ◽  
Smallest Detectable Change ◽  
Osteoarthritis Initiative

Objective.To assess feasibility and reliability of scoring bone marrow lesions (BML) on knee magnetic resonance imaging (MRI) in osteoarthritis using the Outcome Measures in Rheumatology Knee Inflammation MRI Scoring System (KIMRISS), with a Web-based interface and online training with real-time iterative calibration.Methods.Six readers new to the KIMRISS (3 radiologists, 3 rheumatologists) scored sagittal T2-weighted fat-saturated MRI in 20 subjects randomly selected from the Osteoarthritis Initiative data, at baseline and 1-year followup. In the KIMRISS, the reader moves a transparent overlay grid within a Web-based interface to fit bones, then clicks or touches each region containing BML per slice, to score 1 if BML is present. Regional and total scores are automatically calculated. Outcomes include the interreader intraclass correlation coefficients (ICC) and the smallest detectable change (SDC).Results.Scoring took 3–12 min per scan and all readers rated the process as moderately to very user friendly. Despite a low BML burden (average score 2.8% of maximum possible) and small changes, interobserver reliability was moderate to high for BML status and change in the femur and tibia (ICC 0.78–0.88). Four readers also scored the patella reliably, whereas 2 readers were outliers, likely because of image artifacts. SDC of 1.5–5.6 represented 0.7% of the maximum possible score.Conclusion.We confirmed feasibility of knee BML scoring by new readers using interactive training and a Web-based touch-sensitive overlay system, finding high reliability and sensitivity to change. Further work will include adjustments to training materials regarding patellar scoring, and study in therapeutic trial datasets with higher burden of BML and larger changes.

scholarly journals Osteoarthritic bone marrow lesions almost exclusively colocate with denuded cartilage: a 3D study using data from the Osteoarthritis Initiative

2015 ◽  
Vol 75 (10) ◽  
pp. 1852-1857 ◽  
Author(s):  
Michael A Bowes ◽  
Stewart WD McLure ◽  
Christopher BH Wolstenholme ◽  
Graham R Vincent ◽  
Sophie Williams ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Bone Marrow Lesions ◽  
Osteoarthritis Initiative ◽  
Using Data

scholarly journals OMERACT Hip Inflammation Magnetic Resonance Imaging Scoring System (HIMRISS) Assessment in Longitudinal Study

2019 ◽  
Vol 46 (9) ◽  
pp. 1239-1242
Author(s):  
Jacob L. Jaremko ◽  
Robert G.W. Lambert ◽  
Susanne J. Pedersen ◽  
Ulrich Weber ◽  
Duncan Lindsay ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Bone Marrow ◽  
Longitudinal Study ◽  
Magnetic Resonance ◽  
Scoring System ◽  
Steroid Injection ◽  
Intraclass Correlation ◽  
Hip Osteoarthritis ◽  
Post Injection ◽  
Resonance Imaging

Objective.To assess reliability, feasibility, and responsiveness of Hip Inflammation Magnetic resonance imaging Scoring System (HIMRISS) for bone marrow lesions (BML) in hip osteoarthritis (OA).Methods.HIMRISS was scored by 8 readers in 360 hips of 90 patients imaged pre/post-hip steroid injection. Pre-scoring, new readers trained online to achieve intraclass correlation coefficient (ICC) > 0.80 versus experts.Results.HIMRISS reliability was excellent for BML status (ICC 0.83–0.92). Despite small changes post-injection, reliability of BML change scores was high in femur (0.76–0.81) and moderate in acetabulum (0.42–0.56).Conclusion.HIMRISS should be a priority for further assessment of hip BML in OA, and evaluated for use in other arthropathies.

scholarly journals Magnetic Resonance Image Sequence Influences the Relationship between Bone Marrow Lesions Volume and Pain: Data from the Osteoarthritis Initiative

2015 ◽  
Vol 2015 ◽  
pp. 1-5 ◽  
Author(s):  
Ming Zhang ◽  
Jeffrey B. Driban ◽  
Lori Lyn Price ◽  
Grace H. Lo ◽  
Timothy E. McAlindon
Keyword(s):  
Bone Marrow ◽  
Volume Change ◽  
Statistical Power ◽  
Spin Echo ◽  
Womac Pain ◽  
Bone Marrow Lesions ◽  
3 Dimensional ◽  
Sequence Selection ◽  
Osteoarthritis Progression ◽  
Osteoarthritis Initiative

Subchondral bone marrow lesions (BMLs) are related to structural and symptomatic osteoarthritis progression. However, it is unclear how sequence selection influences a quantitative BML measurement and its construct validity. We compared quantitative assessment of BMLs on intermediate-weighted fat suppressed (IW FS) turbo spin echo and 3-dimensional dual echo steady state (3D DESS) sequences. We used a customized software to measure 30 knees’ (24- and 48-month MR images) BMLs on both sequences. The results showed that the IW FS sequences have much larger BML volumes (median: IW FS = 1840 mm3; DESS = 191 mm3) and BML volume change (between 24 and 48 months) than DESS sequence and demonstrate more BML volume change. The 24-month BML volume on IW FS is correlated with BML volume on DESS (rs= 0.83). BML volume change on IW FS is not significantly correlated with change on DESS. The 24-month WOMAC pain is correlated with the 24-month BMLs on IW FS (rs= 0.39) but not DESS. The change in WOMAC pain is correlated with BML volume change on IW FS (rs= 0.37) but not DESS. Overall, BML quantification on IW FS offers better validity and statistical power than BML quantification on a 3D DESS sequence.

scholarly journals Development and Validation of the OMERACT Rheumatoid Arthritis Magnetic Resonance Tenosynovitis Scoring System in a Multireader Exercise

2017 ◽  
Vol 44 (11) ◽  
pp. 1688-1693 ◽  
Author(s):  
Daniel Glinatsi ◽  
Paul Bird ◽  
Frédérique Gandjbakhch ◽  
Espen A. Haavardsholm ◽  
Charles G. Peterfy ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Magnetic Resonance ◽  
Scoring System ◽  
Intraclass Correlation ◽  
Correlation Coefficients ◽  
Change Score ◽  
Change Scores ◽  
Smallest Detectable Change ◽  
Magnetic Resonance Imaging Mri ◽  
Development And Validation

Objective.To develop and validate a magnetic resonance imaging (MRI) tenosynovitis (TS) score for tendons at the wrist and metacarpophalangeal (MCP) joint levels in patients with rheumatoid arthritis (RA).Methods.Axial T1-weighted precontrast and postcontrast fat-saturated MR image sets of the hands of 43 patients with RA initiating rituximab therapy were obtained at baseline and after 14, 26, 38, or 52 weeks. The MR images were scored twice by 4 readers. Nine tendon compartments of the wrist and 4 flexor tendon compartments at the MCP joints were assessed. Tenosynovitis was scored as follows: 0: No; 1: < 1.5 mm; 2: ≥ 1.5 mm but < 3 mm; 3: ≥ 3 mm peritendinous effusion and/or postcontrast enhancement. Intrareader and interreader intraclass correlation coefficients (ICC), smallest detectable change (SDC), percentage of exact and close agreement (PEA/PCA), and standardized response mean (SRM) were calculated.Results.Intrareader and interreader ICC for status and change scores were very good (≥ 0.80) for total scores for all readers. Intrareader SDC was ≤ 3.0 and interreader SDC was < 2.0. The overall PEA/PCA intrareader and interreader agreements for change scores in all tendons were 73.8%/97.6% and 47.9%/85.0%, respectively. Average SRM was moderate for total scores and 60.5% of the patients had a tenosynovitis change score ≥ SDC.Conclusion.The TS score showed high intrareader and interreader agreement for wrist and finger tendons, with moderate responsiveness, and the majority of the patients showed a change above the SDC. This scoring system may be included as a component of the RAMRIS.

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