scholarly journals Extracellular vesicles derived from small intestinal lamina propria reduce antigen-specific immune response

2021 ◽  
Author(s):  
Tae-Seop Shin ◽  
Jae Yong Park ◽  
Yoon-Keun Kim ◽  
Jae Gyu Kim
Keyword(s):  
Immune Response ◽  
Lamina Propria ◽  
Extracellular Vesicles ◽  
Specific Immune Response ◽  
Intestinal Lamina Propria ◽  
Small Intestinal

scholarly journals Interleukin (IL)-23 mediates Toxoplasma gondii–induced immunopathology in the gut via matrixmetalloproteinase-2 and IL-22 but independent of IL-17

2009 ◽  
Vol 206 (13) ◽  
pp. 3047-3059 ◽  
Author(s):  
Melba Muñoz ◽  
Markus M. Heimesaat ◽  
Kerstin Danker ◽  
Daniela Struck ◽  
Uwe Lohmann ◽  
...  
Keyword(s):  
T Cells ◽  
Toxoplasma Gondii ◽  
Lamina Propria ◽  
Th17 Cells ◽  
Intestinal Inflammation ◽  
Gelatinase A ◽  
Intestinal Lamina Propria ◽  
Small Intestinal ◽  
Th1 Cytokines

Peroral infection with Toxoplasma gondii leads to the development of small intestinal inflammation dependent on Th1 cytokines. The role of Th17 cells in ileitis is unknown. We report interleukin (IL)-23–mediated gelatinase A (matrixmetalloproteinase [MMP]-2) up-regulation in the ileum of infected mice. MMP-2 deficiency as well as therapeutic or prophylactic selective gelatinase blockage protected mice from the development of T. gondii–induced immunopathology. Moreover, IL-23–dependent up-regulation of IL-22 was essential for the development of ileitis, whereas IL-17 was down-regulated and dispensable. CD4+ T cells were the main source of IL-22 in the small intestinal lamina propria. Thus, IL-23 regulates small intestinal inflammation via IL-22 but independent of IL-17. Gelatinases may be useful targets for treatment of intestinal inflammation.

CD4+CD8+ and CD8α+β- T lymphocytes in human small intestinal lamina propria

1998 ◽  
Vol 10 (4) ◽  
pp. 325-330 ◽  
Author(s):  
Mohamed Abuzakouk ◽  
Janet Carton ◽  
Conleth Feighery ◽  
Diarmuid P. OʼDonoghue ◽  
Donald G. Weir ◽  
...  
Keyword(s):  
T Lymphocytes ◽  
Lamina Propria ◽  
Intestinal Lamina Propria ◽  
Small Intestinal
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