CLINICAL FACTORS REGULATE THE PROGNOSIS OF COLORECTAL -CANCER WITH PERITONEAL DISSEMINATION-

Abstract Aim To identify the most relevant clinical factors in the National Bowel Cancer Audit (NBOCA) that contribute to the variation in the quality of care provided in different hospitals for colorectal cancer patients undergoing surgery. Method Data from 36,116 patients with colorectal cancer who had undergone surgery were retrospectively collected from the NBOCA and analysed from 145 and 146 hospitals over two years. A validated multiple linear regression was performed to compare the identified clinical factors with various quality outcomes. The quality outcomes defined in this study were the length of hospitalisation, 2-year mortality, readmission rate, 90-day mortality, and 18-month stoma rate. Results Four clinical factors (laparoscopy rate, abdominal-perineal-resection-of-rectum (APER), pre-operative radiotherapy and patients with distant metastases) were shown to have a significant (p < 0.05) impact on the length of hospitalisation and 18-month stoma rate. 18-month stoma rate was also significantly associated with 2-year mortality. External validation of the regression model demonstrated the Root-Mean-Square-Error of 0.811 and 4.62 for 18-month stoma rate and 2-year mortality respectively. Conclusions Hospitals should monitor the four clinical factors for patients with colorectal cancer during perioperative care. Clinicians should consider these factors along with the individual patients’ history when formulating a management plan for patients with colorectal cancer.

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Alterations in the Oral and Gut Microbiome of Colorectal Cancer Patients and Association with Host Clinical Factors

International Journal of Cancer ◽

10.1002/ijc.33596 ◽

2021 ◽

Author(s):

Yao Wang ◽

Yao Zhang ◽

Yun Qian ◽

Yuan‐Hong Xie ◽

Shan‐Shan Jiang ◽

...

Keyword(s):

Colorectal Cancer ◽

Cancer Patients ◽

Gut Microbiome ◽

Clinical Factors ◽

Colorectal Cancer Patients

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Multiple peritoneal dissemination of T2 colorectal cancer without lymph node metastases: a case report

Journal of Surgical Case Reports ◽

10.1093/jscr/rjaa118 ◽

2020 ◽

Vol 2020 (7) ◽

Author(s):

Yosuke Namba ◽

Yuzo Hirata ◽

Shoichiro Mukai ◽

Toshihiro Nishida ◽

Syo Ishikawa ◽

...

Keyword(s):

Colorectal Cancer ◽

Lymph Node ◽

Lymph Node Metastases ◽

Peritoneal Dissemination ◽

Abdominal Cavity ◽

Muscularis Propria ◽

Ileocecal Resection ◽

Pathology Report ◽

Ascending Colon ◽

Node Metastases

Abstract Most cases of peritoneal dissemination of colorectal cancers are from T3 or T4 tumors. A 61-year-old woman was admitted for examination of a positive fecal occult blood test. Colonoscopy showed an ascending colon tumor that was diagnosed as an adenocarcinoma with massive submucosal invasion. Imaging modality revealed numerous nodules throughout the abdominal cavity. Peritoneal dissemination of the ascending colon or ovarian cancer and pseudomyxoma peritonei were considered in the preoperative differential diagnoses, and laparoscopic ileocecal resection was performed. Intraperitoneal observation revealed numerous white nodules in the peritoneum, omentum and Douglas fossa. Both the nodules and tumor were diagnosed as mucinous carcinoma based on a pathology report. The tumor invasion depth was limited to muscularis propria, and no regional lymph node metastasis was detected. Peritoneal dissemination of the ascending colon cancer was considered. We report a rare case of multiple peritoneal dissemination of T2 colorectal cancer without lymph node metastases.

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Brain metastases from colorectal cancer: main clinical factors conditioning outcome

International Journal of Colorectal Disease ◽

10.1007/s00384-013-1781-y ◽

2013 ◽

Vol 29 (2) ◽

pp. 201-208 ◽

Cited By ~ 19

Author(s):

Elena Magni ◽

Luigi Santoro ◽

Paola S. Ravenda ◽

Maria C. Leonardi ◽

Guido Bonomo ◽

...

Keyword(s):

Colorectal Cancer ◽

Brain Metastases ◽

Clinical Factors

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Targeting Hyaluronic Acid and Peritoneal Dissemination in Colorectal Cancer

Clinical Colorectal Cancer ◽

10.1016/j.clcc.2021.11.008 ◽

2021 ◽

Author(s):

Mr Faris Soliman ◽

Dr Lin Ye ◽

Dr Wenguo Jiang ◽

Miss Rachel Hargest

Keyword(s):

Colorectal Cancer ◽

Hyaluronic Acid ◽

Peritoneal Dissemination

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Efficacy of retreatment with anti-EGFRs in metastatic colorectal cancer is not predictable by clinical factors related to prior lines of therapy: a multi-institutional analysis

Annals of Oncology ◽

10.1093/annonc/mdz156.026 ◽

2019 ◽

Vol 30 ◽

pp. iv118

Author(s):

D. Rossini ◽

F. Pagani ◽

A. Pellino ◽

E. Dell’Aquila ◽

N. Liscia ◽

...

Keyword(s):

Colorectal Cancer ◽

Metastatic Colorectal Cancer ◽

Institutional Analysis ◽

Clinical Factors

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Prognostic Impact of Macroscopic Complete Resection and Inflammatory Status for Colorectal Cancer With Peritoneal Dissemination

International Surgery ◽

10.9738/intsurg-d-18-00009.1 ◽

2018 ◽

Vol 103 (7-8) ◽

pp. 331-338

Author(s):

Satoru Yamaguchi ◽

Keisuke Ihara ◽

Yosuke Shida ◽

Haruka Yokoyama ◽

Hideo Ogata ◽

...

Keyword(s):

Colorectal Cancer ◽

Peritoneal Metastasis ◽

Peritoneal Dissemination ◽

Prognostic Score ◽

Case Series ◽

Glasgow Prognostic Score ◽

Carbohydrate Antigen ◽

Complete Resection ◽

Prognostic Impact ◽

Inflammatory Status

Objective: To clarify the appropriate treatment policy for colorectal cancer with peritoneal metastasis, case series were analyzed retrospectively. Summary of background data: The frequency of colorectal cancer and peritoneal dissemination occurring simultaneously is 4% to 7%. The prevention of peritoneal metastasis and the development of a strategy for cure are considered important factors in improving the treatment outcome of colorectal cancer. Methods: A total of 60 patients with colorectal cancer with peritoneal dissemination were enrolled in this study. Tumor and host condition characteristics and treatment regimens affecting patient survival were tested by using Kaplan-Meier survival analysis. Results: Histologic type, carbohydrate antigen 19-9, macroscopic complete resection, and Glasgow Prognostic Score were found to be independent prognostic factors for overall survival. Conclusions: Peritoneal carcinomatosis can result in better patient prognoses in patients with well-differentiated carcinoma, less peritoneal spread, low levels of tumor markers, and a low Glasgow Prognostic Score. In these patients, curative resection of peritoneal metastases followed by intensive chemotherapy might be effective.

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