scholarly journals POSTOPERATIVE RESULTS OF CARCINOMA OF PANCREAS AND BILIARY SYSTEM: CLINICAL OBSERVATION FOR 124 CASES WITH OBSTRUCTIVE JAUNDICE

1981 ◽  
Vol 42 (2) ◽  
pp. 130-139
Author(s):  
Masayoshi HASEGAWA ◽  
Ichiro TEDO ◽  
Yoichi GOTO ◽  
Masayoshi KUDO
Keyword(s):  
Obstructive Jaundice ◽  
Clinical Observation ◽  
Biliary System ◽  
Postoperative Results ◽  
Carcinoma Of Pancreas

scholarly journals Clinical profile of patients with obstructive jaundice: a surgeon’s perspectives

2019 ◽  
Vol 6 (6) ◽  
pp. 1876
Author(s):  
Zubair Afzal Khan
Keyword(s):  
Obstructive Jaundice ◽  
Clinical Examination ◽  
Age Groups ◽  
Clinical Profile ◽  
History Taking ◽  
Carcinoma Of Pancreas ◽  
Laboratory Investigations

Background: There are various causes of obstructive jaundice, choledocholithiasis– the commonest. Patients with obstructive jaundice usually present with complain of yellow skin and eyes, pale stools, dark coloured urine, jaundice, and pruritus.Abdominal pain often misleading for diagnosis. The objectives of the study were to study the clinical profile of patients with obstructive jaundice.Methods: The study included the patients clinically diagnosed as suffering from obstructive jaundice. Thorough history taking and clinical examination was done. Patients undergone for various laboratory investigations, and radiological evaluation.Results: A total 201 patients were included in the present study. Males are more affected (55.72%) as compared to females. Elder age groups (>65 years; and 55-65 years) were commonly affected. 58.71% of patients have malignant causes for development of obstructive jaundice as compared to benign causes in 41.29% of patients. Choledocholithiasis (30.35%) is the commonest cause of obstructive jaundice followed by carcinoma of pancreas (25.87%). Jaundice is the commonest symptom of presentation.Conclusions: Better understanding of the clinical profile in the patients with obstructive jaundice will facilitate appropriate management and lead to improved survival.

scholarly journals Undifferentiated Carcinoma of Pancreas Presenting as Obstructive Jaundice

2021 ◽  
pp. 152-155
Author(s):  
A Sekaran ◽  
S Koppula ◽  
DN Reddy ◽  
S Lakhtakia ◽  
B Patodiya
Keyword(s):  
Obstructive Jaundice ◽  
Undifferentiated Carcinoma ◽  
Carcinoma Of Pancreas

scholarly journals TECHNOLOGY OF PALLIATIVE SURGICAL TREATMENT OF PATIENTS WITH UNRESECTABLE CANCER OF THE HEAD OF THE PANCREAS, COMPLICATED BY MECHANICAL JAUNDICE

2019 ◽  
Vol 15 (1-2) ◽  
pp. 40-50
Author(s):  
B.G. Bezrodnyi ◽  
I.V. Kolosovich ◽  
V.P. Slobodjanyk ◽  
O.M. Petrenko ◽  
M.S. Filatov
Keyword(s):  
Surgical Treatment ◽  
Postoperative Complications ◽  
Obstructive Jaundice ◽  
Duodenal Obstruction ◽  
Bypass Surgery ◽  
Pancreatic Head ◽  
Biliary System ◽  
Main Stage ◽  
Safe Procedure ◽  
Group I

Relevance. It is relevant to develop new technological solutions for palliative surgical treatment of patients with unresectable pancreatic head cancer (UPHC), since the incidence of postoperative complications in such patients reaches 25 %, and mortality – 20 %. Objective. To improve the diagnosis and immediate results of palliative surgical treatment of patients with UPHC complicated by obstructive jaundice, duodenal obstruction, and carcinomatous pancreatitis. Materials and methods. At the first stage of the study, criteria for the diagnosis of PHC complications, tactics and methods for their surgical correction were evaluated (group I, 159 patients). After analyzing the results, a new technology for the surgical treatment of patients is formulated, the clinical testing of which was carried out in the second stage. An open, prospective, randomized study included 112 patients with UPHC complicated by obstructive jaundice (group II), who underwent palliative surgical treatment using patented surgical procedures. A comparative analysis of the results of surgical treatment of patients of both groups was carried out. Results. The safety and effectiveness of the simultaneous implementation with biliodigestive gastrodigestive shunting has been proven. The advantages of the tactics of two-stage surgical treatment of patients with signs of liver failure are shown. In patients with high anesthetic and surgical risk, the replacement of open surgery with endoscopic prosthetics of the biliary system and duodenal obstruction is justified. In severe forms of carcinomatous pancreatitis with expansion of the main pancreatic duct, a technique for combined bilio- and pancreatodigestive shunting is proposed. When multiple organ dysfunctions with hepatic-renal, hemorrhagic syndromes are formed in patients with obstructive jaundice, decompression of the biliary system by minimally invasive techniques is shown in the first stage, and the main stage of surgical intervention in the second. As a result, the incidence of postoperative complications was 9,8 %, mortality – 3,7 %. Conclusions. In patients with UPHC cancer complicated by obstructive jaundice, performing instead of traditional biliodigestive bypass surgery combined bilioastrodigestive bypass surgery is a safe procedure that does not increase the frequency of postoperative complications, prevents the need for repeated gastro-digestive interventions, improves the quality of life of patients in the long-term postoperative period. The operation of choice in the surgical treatment of patients with UPHC complicated by obstruction of the biliary system and duodenum with high surgical and anesthetic risk is endoscopic interventions with endoscopic prosthetics of the bile ducts and duodenum.

Heterogeneities in biofilms from clinical isolates under flow conditions

2020 ◽  
Author(s):  
Cindy Cardenas ◽  
Roberto Rusconi
Keyword(s):  
Pancreatic Cancer ◽  
Obstructive Jaundice ◽  
Flow Rate ◽  
Bacterial Attachment ◽  
The Body ◽  
Biliary System ◽  
Plastic Stents ◽  
Microfluidic Channels ◽  
Biliary Stenting ◽  
Luminal Diameter

<p>Pancreatic cancer is the fourth leading cause of cancer death worldwide. The most common sign of presentation of pancreatic cancer is obstructive jaundice, which prevents the drainage of bile into the intestines and it is often associated with decreased survival in patients. Nowadays more than 70% of the patients with biliary obstructive jaundice is treated by biliary stenting; however, biliary stenting disrupts the natural anatomic barrier between the biliary and the gastrointestinal tract, strongly increasing the risk of a bacterial infection. Moreover, duodenal bacteria, by gaining access into the biliary system, can adhere to the stent surface and develop biofilms. Nevertheless, very little is known about the growth of biofilms on the stents and their role in infectious post-operative complications. In particular, the biliary system is an inherently fluid mechanical environment, where the gallbladder provides the driving pressure and the flow rate of the bile going through the ducts depends on the resistance between the gallbladder and the downstream end of the common bile duct. The average flow rate of the bile ranges between approximately 0.5 to 5 ml/min, which depends if the body is fasting or after a meal; this flow rate then corresponds – in the case for example of plastic stents, which are typically 2-4 mm in luminal diameter – to a maximum flow velocity of about 1-40 mm/s and to a shear rate at the inner surface of the stent of 1-80 s<sup>-1</sup>. Therefore, the mechanical stress induced by the bile flow in the stent is likely to play a significant role in the formation of biofilms, as shown by our data. Six clinically relevant isolates from preoperative biliary stents were selected to be grown inside microfluidic channels at different flow rates, in which bacterial attachment and biofilm dynamics were recorded and quantified. We found that fluid flow largely influences biofilm morphology in all the isolates, for which the conditions of flow and shear stress that trigger heterogeneities in biofilm structure have been determined. These results will help us to improve our understanding of biofilm formation in the presence of fluid dynamic environments and eventually consider optimal parameters of flow in the design of medical devices.</p>

scholarly journals Clinical case of combination of cholelithiasis, obstructive jaundice and portal “coral-like” cholangiolithiasis: the issue of terminology

2021 ◽  
Vol 38 (5) ◽  
pp. 146-152
Author(s):  
M. N. Klimentov ◽  
S. N. Styazhkina ◽  
O. V. Medvedeva ◽  
V. A. Pestereva ◽  
M. S. Dzyuin
Keyword(s):  
Obstructive Jaundice ◽  
Acute Cholecystitis ◽  
Clinical Case ◽  
Clinical Observation

The article describes the clinical observation of a patient operated on for obstructive jaundice with the localization of a stone in the lobar and common hepatic ducts. In anamnesis, there was cholecystectomy for acute cholecystitis 10 years ago.

SEM of Hepatocytes and Biliary Passages in Goldfish Liver

1977 ◽  
Vol 35 ◽  
pp. 556-557
Author(s):  
Waykin Nopanitaya ◽  
Joe W. Grisham ◽  
Johnny L. Carson
Keyword(s):  
Carassius Auratus ◽  
Cell Layer ◽  
Three Dimensional ◽  
Cell Types ◽  
Biliary System ◽  
Fish Food ◽  
Commercial Fish ◽  
Goldfish Carassius Auratus ◽  
Commercial Fish Food

An interesting feature of the goldfish liver is the morphology of the hepatic plate, which is always formed by a two-cell layer of hepatocytes. Hepatic plates of the goldfish liver contain an infrequently seen second type of cell, in the centers of plates between two hepatocytes. A TEH study by Yamamoto (1) demonstrated ultrastructural differences between hepatocytes and centrally located cells in hepatic plates; the latter were classified as ductule cells of the biliary system. None of the previous studies clearly showed a three-dimensional organization of the two cell types described. In the present investigation we utilize SEM to elucidate the arrangement of hepatocytes and bile ductular cells in intralobular plates of goldfish liver.Livers from young goldfish (Carassius auratus), about 6-10 cm, fed commercial fish food were used for this study. Hepatic samples were fixed in 4% buffered paraformaldehyde, cut into pieces, fractured, osmicated, CPD, mounted Au-Pd coated, and viewed by SEM at 17-20 kV. Our observations were confined to the ultrastructure of biliary passages within intralobular plates, ductule cells, and hepatocytes.

Sign in / Sign up

Export Citation Format

Share Document