Antitumour Activity of Indigofera trita on Ehrlich Ascites Carcinoma Induced Mice

The objective of the study is to explore the anticancer activity of di-(2-ethylhexyl) phthalate (DEHP) isolated from Calotropis gigantea flower against Ehrlich ascites carcinoma cells (EAC) in Swiss albino mice. The activity of DEHP was evaluated at doses of 10, 20 and 40 mg kg-1 body mass applied intraperitoneally. DEHP showed a significant decrease in viable cell count (p < 0.05), mass gain (due to tumour burden) and elevated the life span of EAC cell bearing mice. Altered hematological profiles such as RBC, hemoglobin, WBC and differential count were reverted to normal levels in DEHP-treated mice. DEHP also brought back altered biochemical parameters (glucose, cholesterol, triglycerides, blood urea, SALP and SGOT) to normal level. Results of this study indicate that DEHP show potent dose dependent antitumour activity against EAC in vivo.

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Enhanced antitumour activity of doxorubicin and simvastatin combination loaded nanoemulsion treatment against a Swiss albino mouse model of Ehrlich ascites carcinoma

Clinical and Experimental Pharmacology and Physiology ◽

10.1111/1440-1681.13071 ◽

2019 ◽

Vol 46 (5) ◽

pp. 496-505 ◽

Cited By ~ 1

Author(s):

Huda Mohammed Alkreathy ◽

Mayson H. Alkhatib ◽

Safaa Ahmed Al Musaddi ◽

Khadijah Saeed A. Balamash ◽

Nadia Nour Osman ◽

...

Keyword(s):

Mouse Model ◽

Antitumour Activity ◽

Ehrlich Ascites Carcinoma ◽

Swiss Albino Mouse ◽

Ehrlich Ascites

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Antitumour Activity ofBauhinia variegataAgainst Ehrlich Ascites Carcinoma Induced Mice

Pharmaceutical Biology ◽

10.1080/13880200390501947 ◽

2003 ◽

Vol 41 (8) ◽

pp. 604-607 ◽

Cited By ~ 8

Author(s):

B. Rajkapoor ◽

B. Jayakar ◽

N. Murugesh

Keyword(s):

Antitumour Activity ◽

Ehrlich Ascites Carcinoma ◽

Ehrlich Ascites

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Antitumour activity ofTerminalia arjunaleaf against Ehrlich ascites carcinoma in mice

Natural Product Research ◽

10.1080/14786419.2011.561206 ◽

2012 ◽

Vol 26 (12) ◽

pp. 1141-1144 ◽

Cited By ~ 2

Author(s):

Moulisha Biswas ◽

Sanjib Bhattacharya ◽

Ashoke K. Ghosh ◽

R.B. Suresh Kumar ◽

Samit Bera ◽

...

Keyword(s):

Antitumour Activity ◽

Ehrlich Ascites Carcinoma ◽

Ehrlich Ascites

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Antitumor activity of Manilkara zapota (L.) fruits against Ehrlich ascites carcinoma in mice

Biologija ◽

10.6001/biologija.v61i3-4.3206 ◽

2015 ◽

Vol 61 (3-4) ◽

Cited By ~ 2

Author(s):

M. Abdul Khalek ◽

Ziasmin Khatun ◽

M. Rowshanul Habib ◽

M. Rezaul Karim

Keyword(s):

Anticancer Agents ◽

Antitumour Activity ◽

Hematological Parameters ◽

Ehrlich Ascites Carcinoma ◽

Artemia Salina ◽

Hemoglobin Content ◽

Manilkara Zapota ◽

Ehrlich Ascites ◽

Wbc Count

As a part of searching for potential anticancer agents from natural sources, this investigation was carried out to evaluate the antitumor effect of ethyl acetate extract of Manilkara zapota (L.) fruits (EEFM) against Ehrlich acsites carcinoma (EAC) in Swiss albino mice. The antitumour activity of EEFM has been evaluated against Ehrlich ascites carcinoma (EAC) at the doses of 50 and 100 mg/kg body weight. Treatment with EEFM (at 100 mg/kg body) showed a significant increase in the survival time and decrease in the viable tumor cell count and weight gain in the EAC tumor hosts. Improvement in the altered hematological parameters following the EEFM treatment, like hemoglobin content, RBC and WBC count of the tumor bearing mice, have also been observed. During tumor progression, altered biochemical (SALP and SGOT) parameters were also significantly restored in EEFM-treated mice at 100 mg/kg. In brine shrimp lethality bioassay, the cytotoxicity against Artemia salina in terms of LD50 was found to be 3.06 μg/ml for EEFM. So, the results of this study conclude that in vivo the EEFM was effective in inhibiting the growth of EAC.

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