scholarly journals Antitumour evaluation of di-(2-ethylhexyl) phthalate (DEHP) isolated from Calotropis gigantea L. flower / Evaluacija antitumorskog djelovanja di-(2-etilheksil)-ftalata (DEHP) izoliranog iz cvjetova Calotropis gigantea L.

2012 ◽  
Vol 62 (4) ◽  
pp. 607-615 ◽  
Author(s):  
Muhammad Rowshanul Habib ◽  
Muhammad Rezaul Karim
Keyword(s):  
Antitumour Activity ◽  
Viable Cell ◽  
Mass Gain ◽  
Ehrlich Ascites Carcinoma ◽  
Differential Count ◽  
Calotropis Gigantea ◽  
Ehrlich Ascites ◽  
Ethylhexyl Phthalate ◽  
Dose Dependent

The objective of the study is to explore the anticancer activity of di-(2-ethylhexyl) phthalate (DEHP) isolated from Calotropis gigantea flower against Ehrlich ascites carcinoma cells (EAC) in Swiss albino mice. The activity of DEHP was evaluated at doses of 10, 20 and 40 mg kg-1 body mass applied intraperitoneally. DEHP showed a significant decrease in viable cell count (p < 0.05), mass gain (due to tumour burden) and elevated the life span of EAC cell bearing mice. Altered hematological profiles such as RBC, hemoglobin, WBC and differential count were reverted to normal levels in DEHP-treated mice. DEHP also brought back altered biochemical parameters (glucose, cholesterol, triglycerides, blood urea, SALP and SGOT) to normal level. Results of this study indicate that DEHP show potent dose dependent antitumour activity against EAC in vivo.

Antitumor activity of Manilkara zapota (L.) fruits against Ehrlich ascites carcinoma in mice

Biologija ◽  
2015 ◽  
Vol 61 (3-4) ◽  
Author(s):  
M. Abdul Khalek ◽  
Ziasmin Khatun ◽  
M. Rowshanul Habib ◽  
M. Rezaul Karim
Keyword(s):  
Anticancer Agents ◽  
Antitumour Activity ◽  
Hematological Parameters ◽  
Ehrlich Ascites Carcinoma ◽  
Artemia Salina ◽  
Hemoglobin Content ◽  
Manilkara Zapota ◽  
Ehrlich Ascites ◽  
Wbc Count

As a part of searching for potential anticancer agents from natural sources, this investigation was carried out to evaluate the antitumor effect of ethyl acetate extract of <i>Manilkara zapota</i> (L.) fruits (EEFM) against Ehrlich acsites carcinoma (EAC) in Swiss albino mice. The antitumour activity of EEFM has been evaluated against Ehrlich ascites carcinoma (EAC) at the doses of 50 and 100 mg/kg body weight. Treatment with EEFM (at 100 mg/kg body) showed a significant increase in the survival time and decrease in the viable tumor cell count and weight gain in the EAC tumor hosts. Improvement in the altered hematological parameters following the  EEFM treatment, like hemoglobin content, RBC and WBC count of the tumor bearing mice, have also been observed. During tumor progression, altered biochemical (SALP and SGOT) parameters were also significantly restored in EEFM-treated mice at 100 mg/kg. In brine shrimp lethality bioassay, the cytotoxicity against <i>Artemia salina</i> in terms of LD<sub>50</sub> was found to be 3.06 μg/ml for EEFM. So, the  results of this study conclude that <i>in vivo</i> the EEFM was effective in inhibiting the growth of EAC.

Trichosanthes dioica seed lectin inhibits Ehrlich ascites carcinoma cells growth in vivo in mice by inducing G 0 /G 1 cell cycle arrest

2021 ◽  
Author(s):  
Shaikh Shohidul Islam ◽  
Md. Rezaul Karim ◽  
A. K. M. Asaduzzaman ◽  
A. H. M. Khurshid Alam ◽  
Zahid Hayat Mahmud ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Cell Cycle Arrest ◽  
Ehrlich Ascites Carcinoma ◽  
Carcinoma Cells ◽  
Cycle Arrest ◽  
Ehrlich Ascites ◽  
Trichosanthes Dioica

Antitumour Activity of Indigofera trita on Ehrlich Ascites Carcinoma Induced Mice

2007 ◽  
Vol 3 (4) ◽  
pp. 180-185 ◽  
Author(s):  
Raju Senthil Kumar ◽  
Balasundaram Jayakar ◽  
Balasubramanian Rajkapoor
Keyword(s):  
Antitumour Activity ◽  
Ehrlich Ascites Carcinoma ◽  
Ehrlich Ascites

Enhanced antitumour activity of doxorubicin and simvastatin combination loaded nanoemulsion treatment against a Swiss albino mouse model of Ehrlich ascites carcinoma

2019 ◽  
Vol 46 (5) ◽  
pp. 496-505 ◽  
Author(s):  
Huda Mohammed Alkreathy ◽  
Mayson H. Alkhatib ◽  
Safaa Ahmed Al Musaddi ◽  
Khadijah Saeed A. Balamash ◽  
Nadia Nour Osman ◽  
...  
Keyword(s):  
Mouse Model ◽  
Antitumour Activity ◽  
Ehrlich Ascites Carcinoma ◽  
Swiss Albino Mouse ◽  
Ehrlich Ascites

scholarly journals In vitro and in vivo evaluation of antitumor activity of methanolic extract of Argyreia nervosa leaves on Ehrlich ascites carcinoma

2015 ◽  
Vol 10 (2) ◽  
pp. 399
Author(s):  
Bhawna Sharma ◽  
Isha Dhamija ◽  
Sandeep Kumar ◽  
Hema Chaudhary
Keyword(s):  
Antitumor Activity ◽  
Solid Tumor ◽  
Methanolic Extract ◽  
Ehrlich Ascites Carcinoma ◽  
Ehrlich Ascites ◽  
Wide Range ◽  
Antioxidant Parameters ◽  
Argyreia Nervosa

<p>The herb of importance like <em>Argyreia nervosa</em> has shown wide range of pharmacological activities. Its methanolic extract of <em>A. nervosa</em> has been explored against Ehrlich ascites carcinoma (EAC) induced liquid and solid tumor in mice. Liquid and solid tumors were induced by intraperitoneal and subcutaneous transplantation of EAC cells in Balb/C mice. Significant and dose dependant results are observed when the mice are sacrificed on 15<sup>th</sup> day for estimation of tumor proliferation, hematological, biochemical and hepatic antioxidant parameters. Mean survival time (days) was increased to 36.5 from 20.5 extract treated mice. The extract also showed a decrease (p&lt;0.001) in body weight and percentage reduction in tumor volume respectively when it was evaluated in solid tumor induced mice for a period of 30 days.  From the result it was concluded that the extract has as a potent antitumor activity and that is comparable to 5-fluorouracil.</p><p> </p>

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