Breast cancer is one of the leading causes of death worldwide. Breast cancer cells demonstrate uncontrolled
proliferation, and high metastatic capacity. They can obtain resistance to chemotherapy and radiotherapy. This has resulted
in troublesome problems in its treatment. Nature as a rich source of plant derived-natural products with anti-tumor activity
can be of interest in breast cancer therapy. Ginsenosides are triterpenoid saponins and considered as secondary metabolites
exclusively found in Panax species. From immemorial times, ginsenosides have been applied in treatment of various
disorders such as diabetes, inflammatory diseases, neurological disorders, and particularly, cancer. In the present review,
we highlight anti-tumor activity of ginsenosides against breast cancer cells. Ginsenosides are able to induce apoptosis and
cell cycle arrest. They interfere with breast cancer metastasis via inhibiting epithelial-to-mesenchymal transition, matrix
metalloproteinase proteins and angiogenesis. Ginsenosides can promote efficacy of chemotherapy via suppressing migration
and proliferation. Molecular pathways such as phosphatidylinositol 3-kinase (PI3K)/protein kinase B (Akt), insulin-like
growth factor-1, Wnt, microRNAs and long non-coding RNAs are affected by ginsenosides in suppressing breast cancer
malignancy. Consequently, ginsenosides are versatile compounds in breast cancer therapy by suppressing growth, and
invasion, as well as promoting their sensitivity to chemotherapy.