Hair Cortisol Levels to Monitor Hypothalamic-Pituitary-Adrenal Axis Activity in Healthy Dairy Cows

Inhaled corticosteroids have become an important therapeutic option in the treatment of childhood asthma. The preparations currently available for pediatric use (beclomethasone dipropionate and triamcinolone acetonide) do not, in general, cause significant hypothalamic-pituitary-adrenal axis suppression and physical signs of glucocorticoid excess have not been described with their use. We report an 8-year-old girl with asthma in whom obesity, hirsutism, and growth retardation developed during treatment with inhaled triamcinolone acetonide alone. Laboratory studies showed suppression of endogenous cortisol production but did not demonstrate suppression of the hypothalamic-pituitary-adrenal axis. Cessation of inhaled triamcinolone acetonide therapy resulted in resolution of obesity and hirsutism, resumption of normal growth, and a return to normal of serum cortisol levels and urinary 17-hydroxycorticosteroid excretion. Careful monitoring of growth velocity and (if clinically indicated) morning serum cortisol levels in asthmatic children using inhaled corticorsteroids will detect the rare instance of glucocorticoid excess resulting from systemic absorption of these drugs.

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Hair cortisol as a marker of hypothalamic-pituitary-adrenal Axis activity in female patients with major depressive disorder

Metabolic Brain Disease ◽

10.1007/s11011-017-9952-0 ◽

2017 ◽

Vol 32 (2) ◽

pp. 577-583 ◽

Cited By ~ 28

Author(s):

Ksenia Pochigaeva ◽

Tatiana Druzhkova ◽

Alexander Yakovlev ◽

Mikhail Onufriev ◽

Maria Grishkina ◽

...

Keyword(s):

Major Depressive Disorder ◽

Depressive Disorder ◽

Hypothalamic Pituitary Adrenal Axis ◽

Hair Cortisol ◽

Major Depressive ◽

Hypothalamic Pituitary Adrenal ◽

Female Patients ◽

Adrenal Axis ◽

Pituitary Adrenal Axis

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Hair cortisol level as a retrospective marker of hypothalamic–pituitary–adrenal axis activity in horse foals

The Veterinary Journal ◽

10.1016/j.tvjl.2012.04.006 ◽

2012 ◽

Vol 194 (1) ◽

pp. 131-132 ◽

Cited By ~ 26

Author(s):

Antonella Comin ◽

Maria C. Veronesi ◽

Marta Montillo ◽

Massimo Faustini ◽

Silvia Valentini ◽

...

Keyword(s):

Cortisol Level ◽

Hypothalamic Pituitary Adrenal Axis ◽

Hair Cortisol ◽

Hypothalamic Pituitary Adrenal ◽

Adrenal Axis ◽

Pituitary Adrenal Axis

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Hair-Normalized Cortisol Waking Response as a Novel Biomarker of Hypothalamic-Pituitary-Adrenal Axis Activity following Acute Trauma: A Proof-of-Concept Study with Pilot Results

Pain Research and Treatment ◽

10.1155/2013/876871 ◽

2013 ◽

Vol 2013 ◽

pp. 1-9 ◽

Cited By ~ 3

Author(s):

David M. Walton ◽

Joy C. MacDermid ◽

Evan Russell ◽

Gideon Koren ◽

Stan Van Uum

Keyword(s):

Pain Catastrophizing ◽

Small Sample ◽

Hypothalamic Pituitary Adrenal Axis ◽

Self Report ◽

Current Evidence ◽

Stress System ◽

Hair Cortisol ◽

Hypothalamic Pituitary Adrenal ◽

Adrenal Axis ◽

Pituitary Adrenal Axis

The mechanisms underlying the development of persistent posttraumatic pain and disability remain elusive. Recent evidence suggests that disordered stress-system pathway (hypothalamic-pituitary-adrenal axis) activity may be responsible for the genesis and maintenance of long-term sensory and emotional problems. However, confidence in current evidence is limited by the necessarily retrospective collection of data. Hair cortisol can serve as a calendar of HPA axis activity going back several months prior to injury. The purposes of this pilot study were to determine the feasibility of using hair cortisol and hair-normalized salivary cortisol as biomarkers of distress following traumatic injuries of whiplash or distal radius fracture. Ten subjects provided complete data within 3 weeks of injury. Hair cortisol, cortisol waking response (CWR), and mean daily cortisol (MDC) were captured at inception, as were self-report indicators of pain, disability, and pain catastrophizing. Pain and disability were also captured 3 months after injury. Results indicate that cortisol waking response may be a useful biomarker of current distress as measured using the pain catastrophizing scale, especially when normalized to 3-month hair cortisol (r=0.77 raw, 0.93 normalized). Hair-normalized CWR may also have predictive capacity, correlating with 3-month self-reported disability at r=0.70. While promising, the results must be viewed in light of the small sample.

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Toxic stress, health and nutrition among Brazilian children in shelters

BMC Pediatrics ◽

10.1186/s12887-021-02577-4 ◽

2021 ◽

Vol 21 (1) ◽

Author(s):

Adriana César da Silveira ◽

Álvaro Jorge Madeiro Leite ◽

Poliana Coelho Cabral ◽

Ariclécio Cunha de Oliveira ◽

Keciany Alves de Oliveira ◽

...

Keyword(s):

Dental Caries ◽

Negative Impact ◽

Cross Sectional Study ◽

Hypothalamic Pituitary Adrenal Axis ◽

Toxic Stress ◽

Cross Sectional ◽

Hypothalamic Pituitary Adrenal ◽

Adrenal Axis ◽

Cortisol Levels ◽

Pituitary Adrenal Axis

Abstract Background Living in a shelter is an adverse experience that generates toxic stress. This situation can cause the dysregulation of the hypothalamic-pituitary-adrenal axis and exert a negative impact on health.The aim of the present study was to determine the association between toxic stress and social, clinical and nutritional characteristics in children at welfare institutions in a city of northeastern of Brazil. Methods An analytical, cross-sectional study was conducted with male and female children up to 60 months of age who live in shelters. Hair cortisol was used for the assessment of stress (immunoassay). The anthropometric data collected were height for age, body mass index for age, arm circumference for age, and head circumference for age (expressed in z-scores). We also evaluated food intake using markers proposed by the Brazilian Dietary and Nutritional Vigilance Surveillance System as well as the occurrence of dental caries and anemia. Results Sixty-three children one to 60 months of age participated in the present study. Asthma was the most frequent disease (11.1%). The prevalence of short stature, anemia and dental caries in the sample was 22.2, 22.2 and 9.4%, respectively. Cortisol levels ranged from 0.93 pg/mg to 391.29 pg/mg (median: 6.17 pg/mg). Higher cortisol levels were found in children with illnesses (p = 0.012) and those who had been hospitalized after being admitted to the institutions (p = 0.001). Conclusions The majority of children had unhealthy eating behavior. The cortisol concentrations found in the present study were suggestive of dysregulation of the hypothalamic-pituitary-adrenal axis. Hypercortisolism was associated with illness and hospitalization.

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Transsphenoidal pituitary adenoma resection: do early post-operative cortisol levels predict permanent long-term hypocortisolism?

Neurosurgical Review ◽

10.1007/s10143-021-01643-w ◽

2021 ◽

Author(s):

Vicki M. Butenschoen ◽

Alexander von Werder ◽

Stefanie Bette ◽

Veronika Schmette ◽

Nina Schwendinger ◽

...

Keyword(s):

Pituitary Adenoma ◽

Early Morning ◽

Hypothalamic Pituitary Adrenal Axis ◽

Hormone Substitution ◽

Hypothalamic Pituitary Adrenal ◽

Adrenal Axis ◽

Cortisol Levels ◽

Pituitary Adrenal Axis

AbstractTranssphenoidal surgery provides a minimal invasive treatment for pituitary adenoma. Our aim is to evaluate the endocrinological outcomes after adenoma resection focusing on the corticotroph function, and to identify prognostic factors for an impaired hypothalamic–pituitary–adrenal-axis function (HPA) and the reliability of postoperative early morning serum cortisol measurements. We performed a retrospective analysis of all patients treated for pituitary adenoma from April 2006 to January 2019 in our neurosurgical department. Pituitary function was assessed pre- and postoperatively as well as at 6 weeks to 12 weeks and at 1-year follow-up. Two hundred eleven patients were included. Nine percent of the patients recovered from a preoperative adrenal insufficiency, 10.4% developed a new need for hormone substitution, and a long-term deficiency of the hypothalamic–pituitary–adrenal-axis was observed in 30.9%. Cortisol measurements 5 days after surgery had a lower area under the curve (AUC) than cortisol levels detected after 6 to 12 weeks (AUC 0.740 vs. AUC 0.808) in predicting an intact corticotrope function. The cut-off value determined for cortisol measured after 6 weeks was 6.95 µg/dl (sensitivity of 94%, specificity of 68%). Postoperative early morning cortisol levels seem to be less sensitive and specific in predicting long-term corticotroph function than measurements after 6 weeks and 1 year, emphasizing the importance of endocrine follow-up testing.

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