Controlled Release Oral Dosage Forms: Some Recent Advances in Matrix Type Drug Delivery Systems

2001 ◽  
Vol 1 (5) ◽  
pp. 350-354 ◽  
Author(s):  
Gul Majid Khan
Keyword(s):  
Drug Delivery ◽  
Controlled Release ◽  
Drug Delivery Systems ◽  
Dosage Forms ◽  
Delivery Systems ◽  
Oral Dosage ◽  
Matrix Type ◽  
Recent Advances ◽  
Oral Dosage Forms

scholarly journals MICROSPONGES AS A NEOTERIC CORNUCOPIA FOR DRUG DELIVERY SYSTEMS

2019 ◽  
pp. 4-12
Author(s):  
SARIPILLI RAJESWARI ◽  
VANAPALLI SWAPNA
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Drug Delivery Systems ◽  
Active Agent ◽  
Delivery Systems ◽  
Oral Dosage ◽  
Spherical Particles ◽  
Porous Microspheres ◽  
Oral Dosage Forms

Microsponges (MSPs) are at the forefront of the rapidly developing field of novel drug delivery systems which are gaining popularity due to their use for controlled release and targeted drug delivery. The microsponge delivery system (MDS) is a patented polymeric system consisting of porous microspheres typically 10-25 microns in diameter, loaded with an active agent. They are tiny sponge-like spherical particles that consist of a myriad of interconnecting voids within a non-collapsible structure with a large porous surface through which active ingredient is released in a controlled manner. Microsponge also hold a certification as one of the potential approaches for gastric retention where many oral dosage forms face several physiological restrictions due to non-uniform absorption pattern, inadequate medication release and shorter residence time in the stomach. This type of drug delivery system which is non-irritating, non-allergic, non-toxic, can suspend or entrap a wide variety of substances, and can then be incorporated into a formulated product such as gel, cream, liquid or powder that is why it is called as a “versatile drug delivery system”. It overcomes the drawbacks of other formulations such as frequency of dosing, drug reaction, incompatibility with environmental condition. These porous microspheres were exclusively designed for chronotherapeutic topical drug delivery but attempt to utilize them for oral, pulmonary and parenteral drug delivery were also made. The present review elaborates about the multifunctional microsponge technology including its preparation, characterization, evaluation methods along with recent research and future potential.

scholarly journals FAST DISSOLVING DRUG DELIVERY SYSTEMS: FORMULATION, PREPARATION TECHNIQUES AND EVALUATION

2018 ◽  
Author(s):  
Satbir Singh ◽  
Tarun Virmani ◽  
Reshu Virmani ◽  
Geeta Mahlawat ◽  
Pankaj Kumar
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Oral Drug Delivery ◽  
Dosage Forms ◽  
Delivery Systems ◽  
Oral Dosage ◽  
Oral Drug ◽  
Self Medication ◽  
Onset Of Action ◽  
Fast Disintegrating Tablets

The Fast Dissolving Drug Delivery Systems sets a new benchmark was an expansion that came into existence in the early 1980’s and combat over the use of the different dosage form like tablets, suspension, syrups, capsules which are the other oral drug delivery systems. Fast Dissolving Drug Delivery System (FDTS)  has a major advantage over the conventional dosage forms since the drug gets rapidly disintegrated and dissolves in the saliva without the use of water .In spite of the downside lack of immediate onset of action; these oral dosage forms have valuable purposes such as self medication, increased patient compliance, ease of manufacturing and lack of pain. Hence Fast Disintegrating Tablets (FDTS) technology has been gaining importance now-a-days with wide variety of drugs serving many purposes. Fast Disintegrating Tablets (FDTS) has ever increased their demand in the last decade since they disintegrate in saliva in less than a minute that improved compliance in pediatrics and geriatric patients, who have difficulty in swallowing tablets or liquids. As fast dissolving tablet provide instantaneous disintegration after putting it on tongue, thereby rapid drug absorption and instantaneous bioavailability, whereas Fast dissolving oral films are used as practical alternative to FDTS. These films have a potential to deliver the drug systemically through intragastric, sublingual or buccal route of administration and also has been used for local action. In present review article different aspects of fast dissolving  tablets and films like method of preparations, latest technologies, evaluation parameters are discussed. This study will be useful for the researchers for their lab work.  

scholarly journals Recent Patents on Modified Release Oral Dosage Forms

2021 ◽  
Vol 11 (4-S) ◽  
pp. 195-211
Author(s):  
Atul Pund ◽  
Atishkumar Mundada ◽  
Manoj Magar ◽  
Abhijeet Kadam
Keyword(s):  
Controlled Release ◽  
Sustained Release ◽  
Extended Release ◽  
Dosage Forms ◽  
Delivery Systems ◽  
The Body ◽  
Oral Dosage ◽  
Modified Release ◽  
Delayed Release ◽  
Oral Dosage Forms

Background: Conventional oral dosage forms have limited bioavailability and frequent dosing of the drug is needed to maintain the effective therapeutic concentration in the body. This results in poor patient compliance and fluctuations in the plasma drug levels, especially in the chronic diseases and disorders. Objective: To overcome such problems and to enhance the efficiency and bioavailability of the drug, modified drug delivery systems such as extended release delivery systems (controlled release; sustained release) and delayed release delivery systems are developed which can prolong the release and hence action of the drug in the body. Methods: Through this review, we throw the light on recent patents and patent applications on modified release systems pertaining to oral dosage forms.  The various free patent search databases were used to collect and analyze the information on modified release delivery systems. Results: Modified release systems such as extended release and delayed release delivery systems have been found to be of great significance due to their advantages over immediate release dosage forms. These systems are formulated using various approaches, different types of release controlling polymers such as natural, semisynthetic and synthetic polymers and found to avoid the limitations of conventional oral dosage forms. Conclusion: Modified drug release systems have potential especially, in case of the chronic diseases, mental health disorders and lifestyle diseases and disorders. These systems have unique commercial advantages which will sustain the interest of both the researchers and the pharmaceutical companies. Keywords: Modified release systems, extended release systems, controlled release systems, sustained release systems, delayed release systems, oral dosage forms, multilayer dosage form, multilayered tablets

scholarly journals Isolation and Characterization of Azadirachta indica Gum: A Novel Controlled Release Polymer

2019 ◽  
Vol 9 (4-A) ◽  
pp. 112-114
Author(s):  
Rada Santosh Kumar ◽  
B. Kusuma Latha ◽  
D. Tirumalesh
Keyword(s):  
Drug Delivery ◽  
Controlled Release ◽  
Azadirachta Indica ◽  
Drug Delivery Systems ◽  
Oral Drug Delivery ◽  
Dosage Forms ◽  
Delivery Systems ◽  
Oral Drug ◽  
Controlled Release Polymer ◽  
Azadirachta Indica Gum

Oral Drug Delivery is considered as the holy grail of drug delivery due to its convenience which resulted in high patient compliance of all the drug delivery systems that have been explored, oral drug delivery is the most preferred option for systemic delivery of drug via various pharmaceutical products of different dosage forms. The advantage of administering a single dose of drug which is released over an extended period of time, instead of administering numerous doses, is now a day’s area of interest for formulation scientists in the pharmaceutical industry. For this reason, the conventional dosage forms of drugs are rapidly being replaced by the new and the novel drug delivery systems. Amongst these, the controlled release dosage forms have gradually gained medical acceptance and became extremely popular in modern therapeutics. In order to control the release of drug from its dosage form, an effective controlled release polymer is essential. Though, there are several controlled release polymers available in the market, there is continuous need to develop controlled polymers which are safe and inexpensive. The aim of the work was to isolate and characterize the Azadirachta indica gum as novel controlled release polymer. Keywords: Isolation, Controlled release, Azadirachta indica

scholarly journals GASTRO RETENTIVE DRUG DELIVERY SYSTEM: A SIGNIFICANT TOOL TO INCREASE THE GASTRIC RESIDENCE TIME OF DRUGS

2021 ◽  
pp. 7-11
Author(s):  
KANUPRIYA C. ◽  
NIMRATA SETH ◽  
N. S. GILL
Keyword(s):  
Drug Delivery ◽  
Controlled Release ◽  
Drug Delivery System ◽  
Residence Time ◽  
Delivery System ◽  
Drug Delivery Systems ◽  
Dosage Forms ◽  
Delivery Systems ◽  
Site Specific ◽  
Gastro Retentive

Writing the review on gastro retentive drug delivery systems (GRDDS) was to start up the current literature with a special consequence on several gastro retentive approaches that have become main mode in the field of site-specific orally conduct sustained/controlled release drug delivery. Multi-furious ways have been made in research and development to rate-controlled oral drug delivery systems to solve physiological difficulties, like short gastric residence times (GRT) and unpredictable gastric emptying times (GET). GRDDS is a tool to prolong the GRT, thereby targeting site-specific drug release in the upper gastrointestinal tract (GIT) for local or systemic effect. Oral dosage forms as low bioavailability issues because of their swift gastric transition from the stomach, particularly in the case of drugs that are less soluble at an alkaline pH of the intestine. The drugs that produce their local action in the stomach get quickly emptied and don’t get enough residence time in the stomach. Many efforts have been made to extend the retention time of a drug delivery system to reduce the frequency of dose administration. GRDDS not only prolong dosing intervals but also increase patient compliance beyond the level of existing controlled release dosage forms. This article gives an overview of the advantages, disadvantages, and characterization of gastro retentive drug delivery systems. This also includes commercially available gastro retentive products and patents.

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