scholarly journals Food consumption and advanced β cell autoimmunity in young children with HLA-conferred susceptibility to type 1 diabetes: a nested case-control design

2012 ◽  
Vol 95 (2) ◽  
pp. 471-478 ◽  
Author(s):  
Suvi M Virtanen ◽  
Jaakko Nevalainen ◽  
Carina Kronberg-Kippilä ◽  
Suvi Ahonen ◽  
Heli Tapanainen ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Young Children ◽  
Food Consumption ◽  
Control Design ◽  
Case Control ◽  
Β Cell ◽  
Nested Case Control

scholarly journals Lower prediagnostic serum 25‐hydroxyvitamin D concentration is associated with increased incidence of type 1 diabetes in the U. S. military: a nested case‐control study

2012 ◽  
Vol 26 (S1) ◽  
Author(s):  
Edward Doerr Gorham ◽  
Cedric Frank Garland ◽  
Alina Burgi ◽  
Sharif Burgette Mohr ◽  
Kenneth Zeng ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Case Control Study ◽  
Case Control ◽  
Hydroxyvitamin D ◽  
25 Hydroxyvitamin D ◽  
Nested Case Control ◽  
Control Study

scholarly journals Diabetic Retinopathy May Indicate an Increased Risk of Cardiovascular Disease in Patients With Type 1 Diabetes—A Nested Case-Control Study in Brazil

2019 ◽  
Vol 10 ◽  
Author(s):  
Laura Gomes Nunes Melo ◽  
Paulo Henrique Morales ◽  
Karla Rezende Guerra Drummond ◽  
Deborah Conte Santos ◽  
Marcela Haas Pizarro ◽  
...  
Keyword(s):  
Cardiovascular Disease ◽  
Type 1 Diabetes ◽  
Diabetic Retinopathy ◽  
Case Control Study ◽  
Case Control ◽  
Increased Risk ◽  
Nested Case Control ◽  
Control Study

Rotavirus immunization and type 1 diabetes mellitus: A nested case–control study

2014 ◽  
Vol 6 (4) ◽  
pp. 147-149
Author(s):  
Gabriel Chodick ◽  
Moran Almog ◽  
Shai Ashkenazi ◽  
Tal Sella
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Type 1 Diabetes Mellitus ◽  
Case Control Study ◽  
Case Control ◽  
Nested Case Control ◽  
Control Study

scholarly journals Insulin secretion and sensitivity in the prediction of type 1 diabetes in children with advanced β-cell autoimmunity

2013 ◽  
Vol 169 (4) ◽  
pp. 479-485 ◽  
Author(s):  
Heli T Siljander ◽  
Robert Hermann ◽  
Anne Hekkala ◽  
Jyrki Lähde ◽  
Laura Tanner ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Type 1 Diabetes ◽  
Young Children ◽  
Disease Susceptibility ◽  
Insulin Response ◽  
Diabetic Patients ◽  
Model Assessment ◽  
Β Cell ◽  
Intravenous Glucose

ObjectiveReduced early insulin response has been shown to predict type 1 diabetes (T1D) in first-degree relatives of diabetic patients, while its role, as well as that of insulin resistance, has remained poorly defined in young children representing the general population. The predictive values of these markers and their relation to other risk factors of T1D were assessed in children with advanced β-cell autoimmunity, i.e. persistent positivity for two or more autoantibodies.Design and methodsIntravenous glucose tolerance tests (IVGTTs) were carried out in 218 children withHLA-DQB1-conferred disease susceptibility and advanced β-cell autoimmunity. Baseline, metabolic and growth data were compared between children progressing to diabetes and those remaining unaffected. Hazard ratios for the disease predictors and the progression rate of T1D were assessed.ResultsChildren developing T1D were younger at seroconversion, progressed more rapidly to advanced β-cell autoimmunity and had lower first-phase insulin response (FPIR) and homeostasis model assessment index for insulin resistance (HOMA-IR) than those remaining non-diabetic. The levels of HOMA-IR/FPIR, islet cell antibodies, insulin autoantibodies (IAA) and islet antigen 2 antibodies (IA-2A) were higher in progressors. BMI SDS, FPIR, age at IVGTT and levels of IAA and IA-2A were predictive markers for T1D.ConclusionsYoung age, higher BMI SDS, reduced FPIR and higher levels of IAA and IA-2A predicted T1D in young children withHLA-DQB1-conferred disease susceptibility and advanced β-cell autoimmunity. Disease risk estimates were successfully stratified by the assessment of metabolic status and BMI. The role of insulin resistance as an accelerator of the disease process was minor.

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