scholarly journals Comparison of vitamin D2 and vitamin D3 supplementation in raising serum 25-hydroxyvitamin D status: a systematic review and meta-analysis

2012 ◽  
Vol 95 (6) ◽  
pp. 1357-1364 ◽  
Author(s):  
Laura Tripkovic ◽  
Helen Lambert ◽  
Kathryn Hart ◽  
Colin P Smith ◽  
Giselda Bucca ◽  
...  
Keyword(s):  
Systematic Review ◽  
Vitamin D3 ◽  
Meta Analysis ◽  
Vitamin D2 ◽  
Hydroxyvitamin D ◽  
Vitamin D3 Supplementation ◽  
25 Hydroxyvitamin D

scholarly journals Vitamin D for Autism Spectrum Disorders:a Protocol for Systematic Review and Meta-analysis

2021 ◽  
Author(s):  
Jing wang ◽  
Xin Chu ◽  
Haoyu Hao ◽  
He Xuemei ◽  
Yu Chen ◽  
...  
Keyword(s):  
Systematic Review ◽  
Vitamin D ◽  
Vitamin D3 ◽  
Meta Analysis ◽  
Vitamin D Supplementation ◽  
Hydroxyvitamin D ◽  
Subgroup Analyses ◽  
25 Hydroxyvitamin D ◽  
Meta Analyses ◽  
Core Symptoms

Abstract IntroductionAutism spectrum disorder(ASD) is a neurodevelopmental disorder characterized by repetitive and stereotypic behavior, impaired social interactions and communications. An increasing number of reseachers suggested that vitamin D may be participated in the pathogenesis of ASD, and vitamin D deficiency may be one of the causes of ASD.Meanwhile, some studies have shown that vitamin D can improve the core symptoms in ASD children.On top of updating the latest systematic review on vitamin D supplementation and ASD, we aim to conduct the meta-analyses of trials on vitamin D3 supplementation and ASD. Besides, we will conduct for the first time subgroup analyses based on individual patient data collected from randomised controlled trials.Methods and analysisA systematic review and individual patient data meta-analysis on randomised placebo-controlled trials with a vitamin D3 intervention. All studies are searched from inception without time restriction. The addressed outcomes are 25-hydroxyvitamin D, Childhood Autism Rating Scaleas(CARS), Autism Behavior Checklist (ABC), Social Responsiveness Scale(SRS) and M-CHAT. Trial results will be reanalysed using Cox proportional hazard regression models and meta-analyses are performed. Cochran’s Q-Test and the I2 index will be used to statistically assess the level of heterogeneity, while sensitivity and subgroup analyses serve to identify potential causes of heterogeneity. Subgroup analyses will be conducted for age, sex, 25-hydroxyvitamin D level,vitamin D3 dosing, follow-up time,and the core symptoms of ASD. Publication bias will be assessed by funnel plots and Egger’s test. Ethics and disseminationEthical approval is not required since no human beings are involved in this systematic review. Results will be published in a peer-reviewed journal with open access. Strengths and limitations of this study1.Meta-analysis on vitamin D and ASD,we not only study the relationship between vitamin D deficiency and the occurrence of ASD, the preventive and therapeutic effects of vitamin D on ASD, but also the influence factors of vitamin D supplementation on the therapeutic effect of ASD. 2.Assess study quality, sources of heterogeneity and bias minimise the risk of bias and will gather reproducible results.3.Eligible data for meta-analysis may be limited.PROSPERO registration number:CRD42021264097

Circulating 25-hydroxyvitamin D level and prognosis of lung cancer patients: A systematic review and meta-analysis

2017 ◽  
Vol 104 (7-8) ◽  
pp. 675-682 ◽  
Author(s):  
Jian-Da Huang ◽  
Chao-Hui Dong ◽  
Sheng-Wen Shao ◽  
Tong-Jie Gu ◽  
Zhi-Lin Hu ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Systematic Review ◽  
Cancer Patients ◽  
Meta Analysis ◽  
Lung Cancer Patients ◽  
Hydroxyvitamin D ◽  
25 Hydroxyvitamin D

scholarly journals Low Serum 25-hydroxyvitamin D (Vitamin D) Level Is Associated With Susceptibility to COVID-19, Severity, and Mortality: A Systematic Review and Meta-Analysis

2021 ◽  
Vol 8 ◽  
Author(s):  
Mohammad Rizki Akbar ◽  
Arief Wibowo ◽  
Raymond Pranata ◽  
Budi Setiabudiawan
Keyword(s):  
Systematic Review ◽  
Meta Analysis ◽  
Secondary Outcome ◽  
Control Group ◽  
Hydroxyvitamin D ◽  
Literature Searches ◽  
25 Hydroxyvitamin D ◽  
Meta Regression Analysis ◽  
Embase Database ◽  
Low Serum

Background: This systematic review and meta-analysis aimed to assess whether low serum 25-hydroxyvitamin D (25-OHD) level is associated with susceptibility to COVID-19, severity, and mortality related to COVID-19.Methods: Systematic literature searches of PubMed, Scopus, and Embase database up until 9 December 2020. We include published observational prospective and retrospective studies with information on 25-OHD that reported main/secondary outcome. Low serum 25-OHD refers to participants with serum 25-OHD level below a cut-off point ranging from 20 to 30 ng/mL. Other cut-off values were excluded to reduce heterogeneity. The main outcome was mortality defined as non-survivor/death. The secondary outcome was susceptibility and severe COVID-19.Results: There were 14 studies comprising of 999,179 participants. Low serum 25-OHD was associated with higher rate of COVID-19 infection compared to the control group (OR = 2.71 [1.72, 4.29], p < 0.001; I2: 92.6%). Higher rate of severe COVID-19 was observed in patients with low serum 25-OHD (OR = 1.90 [1.24, 2.93], p = 0.003; I2: 55.3%), with a sensitivity of 83%, specificity of 39%, PLR of 1.4, NLR of 0.43, and DOR of 3. Low serum 25-OHD was associated with higher mortality (OR = 3.08 [1.35, 7.00], p = 0.011; I2: 80.3%), with a sensitivity of 85%, specificity of 35%, PLR of 1.3, NLR of 0.44, and DOR of 3. Meta-regression analysis showed that the association between low serum 25-OHD and mortality was affected by male gender (OR = 1.22 [1.08, 1.39], p = 0.002), diabetes (OR = 0.88 [0.79, 0.98], p = 0.019).Conclusion: Low serum 25-OHD level was associated with COVID-19 infection, severe presentation, and mortality.

scholarly journals Vitamin D and Type 1 Diabetes Risk: A Systematic Review and Meta-Analysis of Genetic Evidence

Nutrients ◽  
2021 ◽  
Vol 13 (12) ◽  
pp. 4260
Author(s):  
Liana Najjar ◽  
Joshua Sutherland ◽  
Ang Zhou ◽  
Elina Hyppönen
Keyword(s):  
Systematic Review ◽  
Vitamin D ◽  
Type 1 Diabetes ◽  
Meta Analysis ◽  
Low Frequency ◽  
Nucleotide Polymorphisms ◽  
Hydroxyvitamin D ◽  
Quantitative Synthesis ◽  
25 Hydroxyvitamin D

Several observational studies have examined vitamin D pathway polymorphisms and their association with type 1 diabetes (T1D) susceptibility, with inconclusive results. We aimed to perform a systematic review and meta-analysis assessing associations between selected variants affecting 25-hydroxyvitamin D [25(OH)D] and T1D risk. We conducted a systematic search of Medline, Embase, Web of Science and OpenGWAS updated in April 2021. The following keywords “vitamin D” and/or “single nucleotide polymorphisms (SNPs)” and “T1D” were selected to identify relevant articles. Seven SNPs (or their proxies) in six genes were analysed: CYP2R1 rs10741657, CYP2R1 (low frequency) rs117913124, DHCR7/NADSYN1 rs12785878, GC rs3755967, CYP24A1 rs17216707, AMDHD1 rs10745742 and SEC23A rs8018720. Seven case-control and three cohort studies were eligible for quantitative synthesis (n = 10). Meta-analysis results suggested no association with T1D (range of pooled ORs for all SNPs: 0.97–1.02; p > 0.01). Heterogeneity was found in DHCR7/NADSYN1 rs12785878 (I2: 64.8%, p = 0.02). Sensitivity analysis showed exclusion of any single study did not alter the overall pooled effect. No association with T1D was observed among a Caucasian subgroup. In conclusion, the evidence from the meta-analysis indicates a null association between selected variants affecting serum 25(OH)D concentrations and T1D.

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