scholarly journals All-trans Retinoic Acid Lowers Serum Retinol-Binding Protein 4 Concentrations and Increases Insulin Sensitivity in Diabetic Mice

2009 ◽  
Vol 140 (2) ◽  
pp. 311-316 ◽  
Author(s):  
Daniel-Constantin Manolescu ◽  
Aurelia Sima ◽  
Pangala V. Bhat
Keyword(s):  
Retinoic Acid ◽  
Insulin Sensitivity ◽  
Binding Protein ◽  
Retinol Binding Protein ◽  
Diabetic Mice ◽  
Serum Retinol ◽  
Retinol Binding Protein 4 ◽  
Trans Retinoic Acid ◽  
All Trans Retinoic Acid

Cyanidin 3-glucoside ameliorates hyperglycemia and insulin sensitivity due to downregulation of retinol binding protein 4 expression in diabetic mice

2007 ◽  
Vol 74 (11) ◽  
pp. 1619-1627 ◽  
Author(s):  
Rie Sasaki ◽  
Natsumi Nishimura ◽  
Hiromi Hoshino ◽  
Yasuka Isa ◽  
Maho Kadowaki ◽  
...  
Keyword(s):  
Insulin Sensitivity ◽  
Binding Protein ◽  
Retinol Binding Protein ◽  
Diabetic Mice ◽  
Retinol Binding Protein 4

scholarly journals All-Trans Retinoic Acid Induces Cellular Retinol-Binding Protein in Human Skin In Vivo

1995 ◽  
Vol 105 (1) ◽  
pp. 80-86 ◽  
Author(s):  
Gary J. Fisher ◽  
Ambati P. Reddy ◽  
Subhash C. Datta ◽  
Sewon Kang ◽  
Jong Y. Yi ◽  
...  
Keyword(s):  
Retinoic Acid ◽  
Human Skin ◽  
Binding Protein ◽  
Retinol Binding Protein ◽  
Trans Retinoic Acid ◽  
All Trans Retinoic Acid ◽  
Cellular Retinol Binding Protein

scholarly journals Pioglitazone Lowers Serum Retinol Binding Protein 4 by Suppressing its Expression in Adipose Tissue of Obese Rats

2015 ◽  
Vol 35 (2) ◽  
pp. 778-788 ◽  
Author(s):  
Chaoyu Zhu ◽  
Yuanyuan Xiao ◽  
Xiaohua Liu ◽  
Junfeng Han ◽  
Jianmei Zhang ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Adipose Tissue ◽  
Insulin Sensitivity ◽  
Binding Protein ◽  
Retinol Binding Protein ◽  
Oral Glucose ◽  
Serum Retinol ◽  
Retinol Binding Protein 4 ◽  
Obese Rats ◽  
Pioglitazone Treatment

Background/Aims: Pioglitazone, a peroxisome proliferator-activated receptor γ activator, is clinically used to treat insulin resistance. However, the underlying mechanism of pioglitazone's action remains unclear. We investigated whether, and how, pioglitazone modulates serum level of retinol binding protein 4 (RBP4), an adipocytokine associated with obesity and insulin resistance. Methods: Insulin sensitivity was determined by oral glucose tolerance test, and RBP4 expression was detected by RT-PCR and Western blotting. Results: Pioglitazone treatment significantly decreased serum RBP4 levels in obese rats, which was correlated with reduced body weight and increased insulin sensitivity. Moreover, pioglitazone greatly decreased RBP4 mRNA and protein levels in adipose tissue but not in the liver. Consistently, pioglitazone treatment significantly reduced RBP4 protein expression in 3T3-L1 adipocytes but not in HepG2 cells. Conclusion: These results demonstrate that pioglitazone inhibits the level of serum RPB4 by suppressing RBP4 expression in adipose tissue of obese rats, suggesting that inhibiting RBP4 expression in adipocytes may provide a mechanism by which pioglitazone improves insulin sensitivity in insulin-resistant subjects.

scholarly journals Serum Retinol-Binding Protein 4 (RBP4) and retinol in a cohort of borderline obese women with and without gestational diabetes

2010 ◽  
Vol 43 (3) ◽  
pp. 320-323 ◽  
Author(s):  
Beverly J. Tepper ◽  
Youn-Kyung Kim ◽  
Varsha Shete ◽  
Elena Shabrova ◽  
Loredana Quadro
Keyword(s):  
Gestational Diabetes ◽  
Binding Protein ◽  
Retinol Binding Protein ◽  
Obese Women ◽  
Serum Retinol ◽  
Retinol Binding Protein 4
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