scholarly journals The role of nasal fractional exhaled nitric oxide as an objective parameter independent of nasal airflow resistance in the diagnosis of allergic rhinitis

2018 ◽  
Vol 121 (1) ◽  
pp. 75-76
Author(s):  
Sachio Takeno ◽  
Yutaka Okabayashi ◽  
Takashi Kohno ◽  
Kouhei Yumii ◽  
Katsuhiro Hirakawa
Keyword(s):  
Nitric Oxide ◽  
Allergic Rhinitis ◽  
Exhaled Nitric Oxide ◽  
Nasal Airflow ◽  
Fractional Exhaled Nitric Oxide ◽  
Airflow Resistance ◽  
Objective Parameter

scholarly journals Investigating fractional exhaled nitric oxide (FeNO) in chronic obstructive pulmonary disease (COPD) and asthma–COPD overlap (ACO): a scoping review protocol

BMJ Open ◽  
2017 ◽  
Vol 7 (12) ◽  
pp. e018954 ◽  
Author(s):  
Seyed-Mohammad-Yousof Mostafavi-Pour-Manshadi ◽  
Nafiseh Naderi ◽  
Miriam Barrecheguren ◽  
Abolfazl Dehghan ◽  
Jean Bourbeau
Keyword(s):  
Nitric Oxide ◽  
Chronic Obstructive Pulmonary Disease ◽  
Pulmonary Disease ◽  
Scoping Review ◽  
Exhaled Nitric Oxide ◽  
Cochrane Library ◽  
Chronic Obstructive ◽  
Fractional Exhaled Nitric Oxide ◽  
Obstructive Pulmonary Disease

IntroductionDuring the last decade, many articles have been published, including reviews on fractional exhaled nitric oxide (FeNO) use and utility in clinical practice and for monitoring and identifying eosinophilic airway inflammation, especially in asthma, and evaluating corticosteroid responsiveness. However, the exact role of FeNO in patients with chronic obstructive pulmonary disease (COPD) and its ability to distinguish patients with COPD and those having concomitant asthma, that is, asthma–COPD overlap (ACO) is still unclear and needs to be defined. Due to the broad topics of FeNO in chronic airway disease, we undertook a scoping review. The present article describes the protocol of a scoping review of peer-reviewed published literature specific to FeNO in COPD/ACO over the last decade.Methods and analysisWe used Joanna Briggs Institute Reviewers’ Manual scoping review methodology as well as Levacet al’s and Arkseyet al’s framework as guides. We searched a variety of databases, including Medline, Embase, Cumulative Index to Nursing and Allied Health Literature (CINAHL), Cochrane Library, Web of Science, and BioSciences Information Service (BIOSIS) on 29 June 2016. Additional studies will be recognised by exploring the reference list of identified eligible studies. Screening of eligible studies will be independently performed by two reviewers and any disagreement will be solved by the third reviewer. We will analyse the gathered data from article bibliographies and abstracts.Ethics and disseminationTo investigate the body of published studies regarding the role of FeNO in patients with COPD and its usefulness in the clinical setting, a scoping review can be used as a modern and pioneer model, which does not need ethics approval. By this review, new insights for conducting new research specific to FeNO in COPD/ACO population will emerge. The results of this study will be reported in the scientific meetings and conferences, which aim to provide information to the clinicians, primary care providers and basic science researchers.

scholarly journals Fractional Exhaled Nitric Oxide Measurement in Pulmonary Hypertension: A Follow-Up Study

2017 ◽  
Vol 24 (3) ◽  
pp. 483-488 ◽  
Author(s):  
Nilay Orak Akbay ◽  
Zuleyha Bingol ◽  
Esen Kiyan ◽  
Ekrem Bilal Karaayvaz ◽  
Ahmet Kaya Bilge ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Pulmonary Hypertension ◽  
Pulmonary Function Tests ◽  
Exhaled Nitric Oxide ◽  
World Health ◽  
Control Group ◽  
Healthy Controls ◽  
Fractional Exhaled Nitric Oxide

Pulmonary hypertension (PH) is a fatal disease although significant improvements in treatment are achieved. Easily implemented and noninvasive prognostic techniques are needed while following-up these patients. The aim was to investigate the role of fractional exhaled nitric oxide (FeNO) in follow-up for patients with PH. In this longitudinal study, patients with pulmonary arterial hypertension (PAH) and chronic thromboembolic PH (CTEPH) who were seen in PH Outpatient Clinic, Istanbul Faculty of Medicine, Istanbul University, were enrolled in the study. Echocardiography, 6-minute walking test, brain natriuretic peptide, and FeNO measurements were performed, and World Health Organization functional class was evaluated to all patients at baseline, and third, and sixth months. Right-heart catheterization and pulmonary function tests at the time of diagnosis were recorded. The study comprised 31 patients (23 women, 8 men; mean age: 53.4 ± 17.1 years) with PAH (n = 19) and CTEPH (n = 12) and 80 healthy controls. Patients with PH had lower FeNO values than the control group (16.5 ppb vs 19.8 ppb; P < .05). Fractional exhaled nitric oxide values did not change during follow-up and did not correlate with other follow-up measures except tricuspid annular plane systolic excursion values. Fractional exhaled nitric oxide was higher in the idiopathic PAH subgroup at baseline and at third month than patients with PAH associated with other diseases. Fractional exhaled nitric oxide did not change in patients who had clinical deterioration. As a conclusion; Patients with PH had lower FeNO values than healthy controls, but FeNO did not change significantly during follow-up. Large-scale studies with prolonged follow-up periods are needed to understand the role of FeNO in the follow-up of the patients with PH.

scholarly journals Fractional Exhaled Nitric Oxide and Impulse Oscillometry in Children With Allergic Rhinitis

2014 ◽  
Vol 6 (1) ◽  
pp. 27 ◽  
Author(s):  
Yoon Hee Kim ◽  
Hyun Bin Park ◽  
Min Jung Kim ◽  
Hwan Soo Kim ◽  
Hee Seon Lee ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Allergic Rhinitis ◽  
Exhaled Nitric Oxide ◽  
Impulse Oscillometry ◽  
Fractional Exhaled Nitric Oxide

Measuring nasal nitric oxide in allergic rhinitis patients

2016 ◽  
Vol 130 (11) ◽  
pp. 1064-1071 ◽  
Author(s):  
V S Nesic ◽  
V Z Djordjevic ◽  
V Tomic-Spiric ◽  
Z R Dudvarski ◽  
I A Soldatovic ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Allergic Rhinitis ◽  
Exhaled Nitric Oxide ◽  
Breath Holding ◽  
Healthy Individuals ◽  
Fractional Exhaled Nitric Oxide ◽  
Clinical Tool ◽  
Single Breath ◽  
Nasal Nitric Oxide ◽  
Healthy Participants

AbstractObjective:This study aimed to compare two sampling methods for nasal nitric oxide in healthy individuals and allergic rhinitis patients, and to examine the within-subject reliability of nasal nitric oxide measurement.Methods:The study included 23 allergic rhinitis patients without concomitant asthma and 10 healthy individuals. For all participants, nitric oxide levels were measured non-invasively from the lungs through the mouth (i.e. the oral fractional exhaled nitric oxide) and the nose. Nasal nitric oxide was measured by two different methods: (1) nasal aspiration via one nostril during breath holding and (2) single-breath quiet exhalation against resistance through a tight facemask (i.e. the nasal fractional exhaled nitric oxide).Results:Compared with healthy participants, allergic rhinitis patients had significantly higher average oral and nasal nitric oxide levels. All methods of nitric oxide measurement had excellent reliability.Conclusion:Nasal nitric oxide measurement is a useful and reliable clinical tool for diagnosing allergic rhinitis in patients without asthma in an out-patient setting.

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