scholarly journals Clinical Characteristics of External Auditory Canal Cholesteatoma Associated with a History of Long-term Bisphosphonate Therapy

2018 ◽  
Vol 121 (6) ◽  
pp. 783-790
Author(s):  
Hiromi Kanazawa ◽  
Akihiro Shinnabe ◽  
Eri Takahashi ◽  
Mariya Masuda ◽  
Satoshi Tamii ◽  
...  
Keyword(s):  
External Auditory Canal ◽  
Clinical Characteristics ◽  
Bisphosphonate Therapy ◽  
History Of ◽  
External Auditory Canal Cholesteatoma

Denosumab and bisphosphonate associated bilateral osteonecrosis of the external auditory canal

2021 ◽  
Vol 14 (6) ◽  
pp. e241203
Author(s):  
Harry David True ◽  
Rupert George Ricks ◽  
Joel Anthony Smith
Keyword(s):  
External Auditory Canal ◽  
Otitis Externa ◽  
Bisphosphonate Therapy ◽  
Severe Osteoporosis ◽  
First Case ◽  
History Of ◽  
Loss Of Hearing ◽  
Destructive Osteoarthritis

We present a case of non-surgically managed bilateral osteonecrosis of the external auditory canal with a history of long-term medical therapy for osteoporosis. A 79-year-old woman with severe osteoporosis and destructive osteoarthritis received >10 years of once weekly bisphosphonate therapy before switching to denosumab. Four months later, the patient presented with bilateral loss of hearing and right-sided otalgia. Necrotising otitis externa, cholesteatoma and malignancy were considered but with histology, microbiological and CT assessment, bilateral osteonecrosis of the external auditory canal was diagnosed. Surgical debridement with canalplasty was avoided due to our patient’s comorbidities. Treatment continued for 5 months with regular aural toilet, Terra-Cortril ointment and bismuth-iodine-paraffin paste packing. At 1-year follow-up, bilateral external auditory canals were completely re-epithelialised with no pain or affected hearing. We report the first case of bilateral osteonecrosis of the external auditory canal associated with denosumab and bisphosphonates with successful conservative management.

Clinical characteristics and long-term clinical course of patients with Brugada syndrome without previous cardiac arrest: a multiparametric risk stratification approach

EP Europace ◽  
2019 ◽  
Author(s):  
Konstantinos P Letsas ◽  
George Bazoukis ◽  
Michael Efremidis ◽  
Stamatis Georgopoulos ◽  
Panagiotis Korantzopoulos ◽  
...  
Keyword(s):  
Risk Factors ◽  
Risk Stratification ◽  
Brugada Syndrome ◽  
Clinical Characteristics ◽  
Clinical Course ◽  
Electrophysiological Study ◽  
Rank Test ◽  
History Of ◽  
Event Rates

Abstract Aims Risk stratification in Brugada syndrome (BrS) still represents an unsettled issue. In this multicentre study, we aimed to evaluate the clinical characteristics and the long-term clinical course of patients with BrS. Methods and results A total of 111 consecutive patients (86 males; aged 45.3 ± 13.3 years) diagnosed with BrS were included and followed-up in a prospective fashion. Thirty-seven patients (33.3%) were symptomatic at enrolment (arrhythmic syncope). An electrophysiological study (EPS) was performed in 59 patients (53.2%), and ventricular arrhythmias were induced in 32 (54.2%). A cardioverter defibrillator was implanted in 34 cases (30.6%). During a mean follow-up period of 4.6 ± 3.5 years, appropriate device therapies occurred in seven patients. Event-free survival analysis (log-rank test) showed that spontaneous type-1 electrocardiogram pattern (P = 0.008), symptoms at presentation (syncope) (P = 0.012), family history of sudden cardiac death (P < 0.001), positive EPS (P = 0.024), fragmented QRS (P = 0.004), and QRS duration in lead V2 > 113 ms (P < 0.001) are predictors of future arrhythmic events. Event rates were 0%, 4%, and 60% among patients with 0–1 risk factor, 2–3 risk factors, and 4–5 risk factors, respectively (P < 0.001). Current multiparametric score models exhibit an excellent negative predictive value and perform well in risk stratification of BrS patients. Conclusions Multiparametric models including common risk factors appear to provide better risk stratification of BrS patients than single factors alone.

Clinical characteristics of pediatric external auditory canal cholesteatoma

2016 ◽  
Vol 87 ◽  
pp. 5-10 ◽  
Author(s):  
Chul Ho Jang ◽  
Young Yoon Kim ◽  
Jong Yuap Seong ◽  
Sung Hoon Kang ◽  
Eun Kyung Jung ◽  
...  
Keyword(s):  
External Auditory Canal ◽  
Clinical Characteristics ◽  
External Auditory Canal Cholesteatoma

Clinical Characteristics of External Auditory Canal Cholesteatoma in Children

2008 ◽  
Vol 139 (5) ◽  
pp. 661-664 ◽  
Author(s):  
Yeo-Hoon Yoon ◽  
Chan Hee Park ◽  
Kim Eung-Hyub ◽  
Yong Ho Park
Keyword(s):  
External Auditory Canal ◽  
Clinical Characteristics ◽  
External Auditory Canal Cholesteatoma

scholarly journals Characteristics and long-term outcomes of childhood glaucoma: a retrospective-cohort study

F1000Research ◽  
2021 ◽  
Vol 10 ◽  
pp. 165
Author(s):  
Supawan Surukrattanaskul ◽  
Pukkapol Suvannachart ◽  
Sunee Chansangpetch ◽  
Anita Manassakorn ◽  
Visanee Tantisevi ◽  
...  
Keyword(s):  
Clinical Characteristics ◽  
Secondary Glaucoma ◽  
Research Network ◽  
Congenital Glaucoma ◽  
Long Term Outcomes ◽  
History Of ◽  
The Mean ◽  
Primary Glaucoma

Purpose: To evaluate the clinical characteristics and treatment outcomes of patients with childhood glaucoma. Methods: We retrospectively reviewed the data of patients with childhood glaucoma who visited the glaucoma clinics at the Queen Sirikit National Institute of Child Health and the King Chulalongkorn Memorial Hospital between January 2008 and January 2018. The diagnosis was based on the Childhood Glaucoma Research Network classification. We recorded their clinical characteristics and requirement of any glaucoma interventions. Results: A total of 691 eyes from 423 patients were included in this study. The patients predominantly comprised boys. The average follow-up duration was 71.3±63.8 months. The mean age at presentation was 3.9±4.4 years. Most patients presented with a high initial intraocular pressure (IOP) of 28.5±11.2 mmHg. Glaucoma associated with non-acquired ocular anomalies (22.9%) was the most common subtype, followed by primary congenital glaucoma (20.8%). We recorded a family history of glaucoma in 6.4% of patients. Most patients had bilateral glaucoma (63.4%) and required at least one intervention (51.5%). The average IOP at the latest follow-up visit was 19.1±10.8 mmHg. All glaucoma types had significantly lower IOP, compared to that at their baselines (all p<0.001). Moreover, most patients had an unfavourable visual acuity (49.5%) at their latest visit. Conclusions: Secondary glaucoma associated with non-acquired ocular anomalies is the most common subtype of glaucoma. All subtypes, including primary glaucoma, were sporadic. The majority of patients had unfavourable visual outcomes. These real-world findings are fundamental to acquire a better understanding of childhood glaucoma.

scholarly journals Splenomegaly in sarcoidosis: Frequency, treatment, prognosis and long-term follow-up

2015 ◽  
Vol 143 (5-6) ◽  
pp. 279-283 ◽  
Author(s):  
Zora Pavlovic-Popovic ◽  
Bojan Zaric ◽  
Zdravko Kosjerina ◽  
Dragana Petrovic
Keyword(s):  
Clinical Characteristics ◽  
Primary Treatment ◽  
Prospective Analysis ◽  
Real Frequency ◽  
Long Term Follow Up ◽  
Splenic Involvement ◽  
History Of ◽  
Treatment Prognosis

Introduction. The splenic involvement is common in sarcoidosis, but its real frequency is still obscure, depending doubtless on the method of splenomegaly detection. Splenomegaly may be accompanied with pain or anemia, leucopenia and thrombocytopenia. Objective. The aim of this study was to investigate the frequency of splenomegaly related to clinical characteristics of sarcoidosis and to solve the dilemma - whether to introduce medicaments, and when to perform splenectomy. Methods. The method of the study is a retrospective and prospective analysis of the patients? material. Results. The study included 540 patients with sarcoidosis in a 20-year period. Of them, 26% had splenomegaly detected by computerized tomography screening. Splenomegaly was more frequently registered in the patients with a longer history of sarcoidosis (38%), as compared to those with a shorter history of the disease (23%) (p<0.05). Splenomegaly was more frequently registered in the patients with other extrapulmonary lesions detected (33%) than in those who had no extrapulmonary manifestations of sarcoidosis (17%) (p<0.01). Indications, possible benefits and complications of splenectomy were analysed in 11 sarcoidosis patients undergoing this intervention for various reasons, of which the follow-up period ranged from one to 20 years. Conclusion. Splenomegaly was more frequent in chronic cases or in the patients with established sarcoid lesions of other extrapulmonary organs. The primary treatment of uncomplicated symptomatic splenic sarcoidosis includes medicamentous therapy. Occasionally, splenectomy is required. Prognostically, splenomegaly indicates an unfavorable course of the disease.

scholarly journals A Typical Metatarsal Fracture in a Patient on Long-Term Bisphosphonate Therapy

2019 ◽  
Vol 6 (4) ◽  
pp. 25-30
Author(s):  
Bijan Valiollahi ◽  
◽  
Mostafa Salehpour ◽  
Hamidreza Bashari ◽  
Shoeib Majdi ◽  
...  
Keyword(s):  
Rare Case ◽  
Femoral Shaft ◽  
Bisphosphonate Therapy ◽  
Mineral Density ◽  
Pathological Fractures ◽  
Femoral Shaft Fractures ◽  
T Score ◽  
Metatarsal Fracture ◽  
History Of

Bisphosphonates, more particularly alendronate, are a popular category of drugs in the treatment of postmenopausal and corticosteroid-induced osteoporosis. The present study contends that the long-term consumption of bisphosphonates causes not only subtrochanteric and femoral shaft fractures but also pathological fractures at other musculoskeletal sites. This report presents a rare case of alendronate-induced pathological metatarsal fracture in a 59-year-old female with a history of cuboid fracture following a twisting with abnormal Bone Mineral Density (BMD) (T score: −3.5; lumbar spine and −2.6; proximal femur).

Clinical Characteristics and Treatment Outcomes for Patients With External Auditory Canal Cholesteatoma

2018 ◽  
Vol 39 (2) ◽  
pp. 189-195 ◽  
Author(s):  
Shinya Morita ◽  
Yuji Nakamaru ◽  
Atsushi Fukuda ◽  
Keishi Fujiwara ◽  
Kimiko Hoshino ◽  
...  
Keyword(s):  
Treatment Outcomes ◽  
External Auditory Canal ◽  
Clinical Characteristics ◽  
External Auditory Canal Cholesteatoma

External auditory canal cholesteatoma and benign necrotising otitis externa: clinical study of 95 cases in the Capital Region of Denmark

2018 ◽  
Vol 132 (06) ◽  
pp. 514-518 ◽  
Author(s):  
J Hertz ◽  
C Siim
Keyword(s):  
External Auditory Canal ◽  
Otitis Externa ◽  
Treatment Time ◽  
Treatment Strategies ◽  
Retrospective Case ◽  
Capital Region ◽  
Leading Role ◽  
Tertiary Hospitals ◽  
History Of ◽  
External Auditory Canal Cholesteatoma

AbstractObjectiveTo identify epidemiological and pathophysiological factors, and treatment strategies, in external auditory canal cholesteatoma and benign necrotising otitis externa.MethodsA retrospective case study was conducted of patients suffering from external auditory canal cholesteatoma and benign necrotising otitis externa admitted to tertiary hospitals, in the Capital Region of Denmark, over a five-year period.ResultsEighty-three patients (95 ears) with external auditory canal cholesteatoma or benign necrotising otitis externa were identified. A minimum incidence rate of 0.97 per 100 000 inhabitants per year was demonstrated. Sixty-eight per cent of cases had a history of smoking. Most lesions (74 per cent) were localised in the floor of the ear canal. Treatment time was 3.2 months for patients who had surgery and 6.0 months for those who received conservative treatment.ConclusionIt is suggested that external auditory canal cholesteatoma and benign necrotising otitis externa are in fact the same disease, and therefore the diagnosis of external auditory canal cholesteatoma should be changed to benign necrotising otitis externa. Microangiopathy has a leading role in the aetiology. Surgery should be conducted in most cases.

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