Petroleum Prospects Mezen Syncline on Volume-Genetic Modeling Results

Abstract Spore killing in ascomycetes is a special form of segregation distortion. When a strain with the Killer genotype is crossed to a Sensitive type, spore killing is expressed by asci with only half the number of ascospores as usual, all surviving ascospores being of the Killer type. Using population genetic modeling, this paper explores conditions for invasion of Spore killers and for polymorphism of Killers, Sensitives and Resistants (which neither kill, nor get killed), as found in natural populations. The models show that a population with only Killers and Sensitives can never be stable. The invasion of Killers and stable polymorphism only occur if Killers have some additional advantage during the process of spore killing. This may be due to the effects of local sib competition or some kind of "heterozygous" advantage in the stage of ascospore formation or in the short diploid stage of the life cycle. This form of segregation distortion appears to be essentially different from other, well-investigated forms, and more field data are needed for a better understanding of spore killing.

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Correction to De Geus et al. Bivariate Genetic Modeling of Cardiovascular Stress Reactivity: Does Stress Uncover Genetic Variance? (May 2007)

Psychosomatic Medicine ◽

10.1097/01.psy.0000278973.14218.6b ◽

2007 ◽

Vol 69 (5) ◽

pp. 489

Author(s):

&NA;

Keyword(s):

Genetic Variance ◽

Stress Reactivity ◽

Cardiovascular Stress ◽

Genetic Modeling ◽

Cardiovascular Stress Reactivity

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Stability and change in genetic and environmental influences on hand-grip strength in older male twins

Journal of Applied Physiology ◽

10.1152/jappl.2000.89.5.1879 ◽

2000 ◽

Vol 89 (5) ◽

pp. 1879-1883 ◽

Cited By ~ 67

Author(s):

Dorit Carmelli ◽

Terry Reed

Keyword(s):

Grip Strength ◽

Environmental Influences ◽

Hand Grip Strength ◽

Environmental Stability ◽

Phenotypic Correlation ◽

Late Adulthood ◽

Stability And Change ◽

Hand Grip ◽

Genetic Modeling

The aim of this study was to investigate aging-related changes in the contribution of genetic and environmental influences to hand-grip strength in late adulthood. Subjects in this study are 152 intact twin pairs (77 monozygotic and 75 dizygotic pairs) from the National Heart, Lung, and Blood Institute Twin Study assessed repeatedly for hand-grip strength at mean ages of 63 and 73 yr. Structural equation genetic modeling was used to investigate stability and change in the genetic and environmental components of variance of hand-grip strength in late adulthood. Average decline in strength over the 10 yr of follow-up was −1.05 ± 6.8 (SD) kg and was highly significant ( P = 0.003). The test-retest correlation between baseline and follow-up grip strength was 0.62 ( P < 0.001). Bivariate genetic modeling found significant genetic and shared environmental stability in hand-grip strength over the 10 yr of follow-up, with genetic and shared environmental influences accounting for 35 and 48%, respectively, of the test-retest phenotypic correlation. We conclude from these results that stability in hand-grip strength in late adulthood is due primarily to continuity of genetic and familial influences.

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Genetic Component of Noise Sensitivity

Twin Research and Human Genetics ◽

10.1375/twin.8.3.245 ◽

2005 ◽

Vol 8 (3) ◽

pp. 245-249 ◽

Cited By ~ 42

Author(s):

Marja Heinonen-Guzejev ◽

Heikki S. Vuorinen ◽

Helena Mussalo-Rauhamaa ◽

Kauko Heikkilä ◽

Markku Koskenvuo ◽

...

Keyword(s):

Study Design ◽

Twin Study ◽

Genetic Model ◽

Hearing Impaired ◽

Genetic Component ◽

Noise Sensitivity ◽

Quantitative Genetic ◽

Genetic Modeling ◽

Health Related ◽

Age Range

AbstractWe investigated the genetic component of noise sensitivity using a twin-study design. The study sample consisted of 573 same-sexed twin pairs from the Finnish Twin Cohort. The 131 monozygotic (MZ) and 442 dizygotic (DZ) twin pairs with an age range of 31 to 88 years replied to a questionnaire on noise and health-related items in 1988. The noise sensitivity of respondents was defined as high, quite high, quite low or low. MZ pairs were more similar with regards noise sensitivity than DZ pairs, and quantitative genetic modeling indicated significant familiality. The best z-fitting genetic model provided an estimate of heritability of 36% (95% CI = .20–.50) and when hearing impaired subjects were excluded this rose to 40% (95% CI = .24–.54). In conclusion, noise sensitivity does aggregate in families and probably has a genetic component.

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Polymorphisms of Fatty Acid Elongase 2 Gene Afftects Risk of Pulmonary Tuberculosis in China Han Population

Iranian Journal of Public Health ◽

10.18502/ijph.v50i11.7580 ◽

2021 ◽

Author(s):

Min Mu ◽

Li Jing ◽

Yuan-Jie Zou ◽

Xing-Rong Tao ◽

Fei Wang ◽

...

Keyword(s):

Epidemiological Survey ◽

Nucleotide Polymorphism ◽

Dominance Model ◽

Fatty Acid Elongase ◽

Single Nucleotide ◽

Female Population ◽

Genetic Modeling ◽

Male Patients ◽

The Relationship ◽

Control Study

Background: As an infectious disease closely related to Mycobacterium tuberculosis, autoimmunity, inflammation, environment and heredity, the relationship between the single nucleotide polymorphism of elongase 2 gene and the susceptibility to tuberculosis is still unknown. Methods: Between January 2016 and November 2018, a hospital-based case-control study was conducted. This epidemiological survey was conducted in both hospitals every three months. rs3798719, rs1570069, and rs2236212 in ELOVL2 gene were detected by Sanger sequencing. Results: Stratified by gender, the genotypes and allele frequencies of rs3798719, rs1570069 and rs2236212 showed significant differences between the two groups (χ2 = 6.987, P = 0.030), Genetic modeling showed that rs3798719 was statistically different in the overdominance model (χ2 = 4.784, OR = 1.414, 95% CI: 1.036-1.929, P < 0.05). The polymorphism of rs2236212 between male TB patients and healthy controls was statistically different in the dominance model. (χ2 = 4.192, OR = 0.507; 95% CI: 0.262-0.981, P < 0.05). Conclusion: The rs3798719 of ELOVL2 gene may be associated with susceptibility to TB in female population and the rs2236212 of ELOVL2 gene may be associated with TB incidence in male patients.

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