scholarly journals Inhibitory Effects of Mead Acid Supplementation on Acetaminophen-Induced Renal Toxicity in Rats

2020 ◽  
Vol 29 (1) ◽  
pp. 15-25
Author(s):  
Akiko Takenouchi ◽  
Chihiro Koyama ◽  
Yuichi Kinoshita ◽  
Kei Hamazaki ◽  
Hiroyasu Tsukaguchi ◽  
...  
Keyword(s):  
Renal Toxicity ◽  
Inhibitory Effects ◽  
Mead Acid ◽  
Acid Supplementation

scholarly journals Mead acid supplementation does not rescue rats from cataract and retinal degeneration induced by N-methyl-N-nitrosourea

2015 ◽  
Vol 28 (1) ◽  
pp. 11-20 ◽  
Author(s):  
Yuko Emoto ◽  
Katsuhiko Yoshizawa ◽  
Kei Hamazaki ◽  
Yuichi Kinoshita ◽  
Michiko Yuki ◽  
...  
Keyword(s):  
Retinal Degeneration ◽  
Mead Acid ◽  
Acid Supplementation

scholarly journals Suppressive effects of mead acid supplementation on acute liver damage derived from green tea extract

2021 ◽  
Vol 30 (1) ◽  
pp. 60-72
Author(s):  
Yuichi Kinoshita ◽  
Akiko Takenouchi ◽  
Momoka Chatani ◽  
Masahiro Yoshioka ◽  
Yuko Emoto ◽  
...  
Keyword(s):  
Green Tea ◽  
Liver Damage ◽  
Green Tea Extract ◽  
Acute Liver Damage ◽  
Mead Acid ◽  
Acid Supplementation ◽  
Tea Extract

scholarly journals Suppressive effects of mead acid supplementation on acute liver damage model in rats

2020 ◽  
Vol 29 (2) ◽  
pp. 114
Author(s):  
Akiko Takenouchi ◽  
Yuichi Kinoshita ◽  
Yukari Hirayama ◽  
Yumiko Shinke ◽  
Kei Hamazaki ◽  
...  
Keyword(s):  
Liver Damage ◽  
Damage Model ◽  
Acute Liver Damage ◽  
Mead Acid ◽  
Acid Supplementation

Efficacy and Safety of Chunghyul-dan (Qingwie-dan) in Patients with Hypercholesterolemia

2005 ◽  
Vol 33 (02) ◽  
pp. 241-248 ◽  
Author(s):  
Ki Ho Cho ◽  
Heung Sun Kang ◽  
Woo Sang Jung ◽  
Seong Uk Park ◽  
Sang Kwan Moon
Keyword(s):  
Adverse Effect ◽  
Safety Assessment ◽  
Serum Lipids ◽  
Renal Toxicity ◽  
Case Control ◽  
Lipid Lowering ◽  
Therapeutic Effects ◽  
Efficacy And Safety ◽  
Inhibitory Effects ◽  
Coa Reductase

Chunghyul-dan has inhibitory effects on HMG- CoA reductase and pancreatic lipase. We investigated whether Chunghyul-dan has therapeutic effects on humans with hypercholesterolemia. This study was a case-control, open-labeled clinical study. Subjects were treated with Chunghyul-dan (600 mg/day) or Atorvastatin (10 mg/day) for 8 weeks. Serum lipids were checked at baseline after 4 and 8 weeks of medication. While, Chunghyul-dan showed significant lipid-lowering effects, it was less effective than Atorvastatin. In comparison with the histological controls, Chunghyul-dan's effects were superior to placebo. On safety assessment, there was no adverse effect with the use of Chunghyul-dan in hepatic or renal toxicity. In conclusion, we suggest that Chunghyul-dan is a useful herbal medicine for hypercholesterolemia.

Inhibitory effects of bioaccessible anthocyanins and procyanidins from apple, red grape, cinnamon on α-amylase, α-glucosidase and lipase

2020 ◽  
pp. 1-9
Author(s):  
Pınar Ercan ◽  
Sedef Nehir El
Keyword(s):  
Inhibitory Activity ◽  
Digestive Enzymes ◽  
Positive Control ◽  
Anthocyanin Content ◽  
Inhibitory Effects ◽  
Total Anthocyanin ◽  
Total Anthocyanin Content ◽  
Before And After ◽  
Red Grape

Abstract. The goals of this study were to determine and evaluate the bioaccessibility of total anthocyanin and procyanidin in apple (Amasya, Malus communis), red grape (Papazkarası, Vitis vinifera) and cinnamon (Cassia, Cinnamomum) using an in vitro static digestion system based on human gastrointestinal physiologically relevant conditions. Also, in vitro inhibitory effects of these foods on lipid (lipase) and carbohydrate digestive enzymes (α-amylase and α-glucosidase) were performed with before and after digested samples using acarbose and methylumbelliferyl oleate (4MUO) as the positive control. While the highest total anthocyanin content was found in red grape (164 ± 2.51 mg/100 g), the highest procyanidin content was found in cinnamon (6432 ± 177.31 mg/100 g) (p < 0.05). The anthocyanin bioaccessibilities were found as 10.2 ± 1%, 8.23 ± 0.64%, and 8.73 ± 0.70% in apple, red grape, and cinnamon, respectively. The procyanidin bioaccessibilities of apple, red grape, and cinnamon were found as 17.57 ± 0.71%, 14.08 ± 0.74% and 18.75 ± 1.49%, respectively. The analyzed apple, red grape and cinnamon showed the inhibitory activity against α-glucosidase (IC50 544 ± 21.94, 445 ± 15.67, 1592 ± 17.58 μg/mL, respectively), α-amylase (IC50 38.4 ± 7.26, 56.1 ± 3.60, 3.54 ± 0.86 μg/mL, respectively), and lipase (IC50 52.7 ± 2.05, 581 ± 54.14, 49.6 ± 2.72 μg/mL), respectively. According to our results apple, red grape and cinnamon have potential to inhibit of lipase, α-amylase and α-glucosidase digestive enzymes.

Inhibitory Effects of Transposed Letter Neighbours During Silent Sentence Reading

2014 ◽  
Author(s):  
Ascension Pagan ◽  
Hazel Blythe ◽  
Kevin Paterson ◽  
Simon Liversedge
Keyword(s):  
Inhibitory Effects ◽  
Sentence Reading
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