scholarly journals Suppressive effects of mead acid supplementation on acute liver damage model in rats

2020 ◽  
Vol 29 (2) ◽  
pp. 114
Author(s):  
Akiko Takenouchi ◽  
Yuichi Kinoshita ◽  
Yukari Hirayama ◽  
Yumiko Shinke ◽  
Kei Hamazaki ◽  
...  
Keyword(s):  
Liver Damage ◽  
Damage Model ◽  
Acute Liver Damage ◽  
Mead Acid ◽  
Acid Supplementation

scholarly journals Suppressive effects of mead acid supplementation on acute liver damage derived from green tea extract

2021 ◽  
Vol 30 (1) ◽  
pp. 60-72
Author(s):  
Yuichi Kinoshita ◽  
Akiko Takenouchi ◽  
Momoka Chatani ◽  
Masahiro Yoshioka ◽  
Yuko Emoto ◽  
...  
Keyword(s):  
Green Tea ◽  
Liver Damage ◽  
Green Tea Extract ◽  
Acute Liver Damage ◽  
Mead Acid ◽  
Acid Supplementation ◽  
Tea Extract

scholarly journals Effects of Combination of G-CSF and SCF One Week Prior to Liver Injury In Acute liver Damage Model Induced by Thioacetamide Administration

2014 ◽  
Vol 2 (1) ◽  
pp. 21-25
Author(s):  
Ali Asghar Yoonesi ◽  
Durdi Qujeq ◽  
Mohsen Esmaili ◽  
Farideh Feizi ◽  
◽  
...  
Keyword(s):  
Liver Injury ◽  
Liver Damage ◽  
Damage Model ◽  
Acute Liver Damage

Effect of preliminary fasting on development of acute liver damage by D-galactosamine in rats

1989 ◽  
Vol 107 (1) ◽  
pp. 38-41
Author(s):  
D. Adzharov ◽  
N. Donchev ◽  
M. Kerimova ◽  
E. Naidenova ◽  
B. Borov ◽  
...  
Keyword(s):  
Liver Damage ◽  
Acute Liver Damage

Morin protects acute liver damage by carbon tetrachloride (CCl4) in rat

2008 ◽  
Vol 31 (9) ◽  
pp. 1160-1165 ◽  
Author(s):  
Hee Seung Lee ◽  
Kyung-Hee Jung ◽  
Sang-Won Hong ◽  
In-Suh Park ◽  
Chongmu Lee ◽  
...  
Keyword(s):  
Carbon Tetrachloride ◽  
Liver Damage ◽  
Acute Liver Damage

scholarly journals BML-257, a small molecule that protects against drug induced liver injury in zebrafish

2022 ◽  
Author(s):  
Urmila Jagtap ◽  
Sandeep Basu ◽  
Lavanya Lokhande ◽  
Nikhil Bharti ◽  
Chetana Sachidanandan
Keyword(s):  
Liver Injury ◽  
Small Molecule ◽  
Liver Damage ◽  
Protective Action ◽  
Damage Model ◽  
Akt Inhibitor ◽  
Drug Induced ◽  
Specific Expression ◽  
Drug Induced Liver Injury ◽  
Chemical Screen

The use of many essential drugs is restricted due to their deleterious effects on the liver. Molecules that can prevent or protect the liver from drug induced liver injury (DILI) would be valuable in such situations. We used hepatocyte-specific expression of bacterial nitroreductase in zebrafish to cause temporally controlled liver damage. This transgenic line was used to run a whole organism based chemical screen in zebrafish larvae. In this screen we identified BML-257, a potent small molecule AKT inhibitor, that protected the liver against metronidazole-induced liver injury. BML-257 also showed potent prophylactic and pro-regenerative activity in this liver damage model. BML-257 also showed remarkable protective action in two independent toxicological models of liver injury caused by acetaminophen and Isoniazid. This suggests that BML-257 may have the potential to protect against multiple kinds of drug induced liver injury.

Protective and Therapeutic Effects of Curcuma xanthorrhiza on Hepatotoxin-induced Liver Damage

1995 ◽  
Vol 23 (03n04) ◽  
pp. 243-254 ◽  
Author(s):  
Song-Chow Li ◽  
Chun-Ching Lin ◽  
Yun-Ho Lin ◽  
S. Supriyatna ◽  
Chao-Wei Teng
Keyword(s):  
Carbon Tetrachloride ◽  
Liver Damage ◽  
Intraperitoneal Administration ◽  
Therapeutic Effects ◽  
Acute Liver Damage ◽  
Liver Injuries ◽  
Acute Elevation ◽  
Serum Transaminases ◽  
Hepatoprotective Agent ◽  
Curcuma Xanthorrhiza

Curcuma xanthorrhiza Roxb. (Zingiberaceae family, commonly known as temu lawak or Javanese turmeric in Indonesia), which is found both wild and cultivated in Indonesia, has been traditionally used for medicinal purposes. C. xanthorrhiza is also used as a tonic in Indonesia. The aim of the present study is to clarify whether C. xanthorrhiza treatment may prevent acute liver damage induced by acetaminophen and carbon tetrachloride in mice. The results clearly indicated that extract of C. xanthorrhiza could reduce significantly the acute elevation of serum transaminases levels induced by the two kinds of hepatotoxins, and alleviated the degree of liver damage at 24 hours after the intraperitoneal administration of two hepatotoxins. It may be concluded that C. xanthorrhiza can protect the liver from various hepatotoxins, hence C. xanthorrhiza could be useful in the treatment of liver injuries and has promise as a kind of broad spectrum hepatoprotective agent.

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