Virtual Screening

2011 ◽  
pp. 229-245 ◽  
Author(s):  
Alan Talevi ◽  
Eduardo A. Castro ◽  
Luis E. Bruno-Blanch
Keyword(s):  
Latin America ◽  
Virtual Screening ◽  
Drug Development ◽  
Potential Importance ◽  
Screening Approaches

In this chapter, the authors analyze virtual screening advantages and the classification of virtual screening approaches. They also discuss the current and potential importance of virtual screening for drug development in Latin America. Finally, they present a brief overview on virtual screening perspectives.

Discovery of New AKT1 Inhibitors by Combination of In silico Structure Based Virtual Screening Approaches and Biological Evaluations

2019 ◽  
Author(s):  
Filip Fratev ◽  
Denisse A. Gutierrez ◽  
Renato J. Aguilera ◽  
suman sirimulla
Keyword(s):  
Virtual Screening ◽  
Success Rate ◽  
Protein Interactions ◽  
In Silico ◽  
Biological Data ◽  
In Vitro Binding ◽  
Vitro Binding ◽  
Screening Protocol ◽  
Screening Approaches

AKT1 is emerging as a useful target for treating cancer. Herein, we discovered a new set of ligands that inhibit the AKT1, as shown by in vitro binding and cell line studies, using a newly designed virtual screening protocol that combines structure-based pharmacophore and docking screens. Taking together with the biological data, the combination of structure based pharamcophore and docking methods demonstrated reasonable success rate in identifying new inhibitors (60-70%) proving the success of aforementioned approach. A detail analysis of the ligand-protein interactions was performed explaining observed activities.<br>

Identification of novel potential cyclooxygenase-2 inhibitors using ligand- and structure-based virtual screening approaches

2021 ◽  
pp. 1-23
Author(s):  
Josiane V. Cruz ◽  
Silvana Giuliatti ◽  
Levy B. Alves ◽  
Raí C. Silva ◽  
Elenilze F. B. Ferreira ◽  
...  
Keyword(s):  
Virtual Screening ◽  
Cyclooxygenase 2 ◽  
Cyclooxygenase 2 Inhibitors ◽  
Screening Approaches

Virtual screening approaches for the identification of non-lipid autotaxin inhibitors

2008 ◽  
Vol 16 (4) ◽  
pp. 1784-1795 ◽  
Author(s):  
Abby L. Parrill ◽  
Uniqua Echols ◽  
Tran Nguyen ◽  
Truc-Chi T. Pham ◽  
Adrienne Hoeglund ◽  
...  
Keyword(s):  
Virtual Screening ◽  
Screening Approaches

Insilico studies on anthrax lethal factor inhibitors: Pharmacophore modeling and virtual screening approaches towards designing of novel inhibitors for a killer

2010 ◽  
Vol 29 (2) ◽  
pp. 256-265 ◽  
Author(s):  
Jyoti Roy ◽  
Uday Chandra Kumar ◽  
Pavan Kumar Machiraju ◽  
Ravi Kumar Muttineni ◽  
Suneel Kumar B.V.S ◽  
...  
Keyword(s):  
Virtual Screening ◽  
Lethal Factor ◽  
Pharmacophore Modeling ◽  
Anthrax Lethal Factor ◽  
Screening Approaches

scholarly journals MINI-PARLIAMENTS IN THE POST-DICTATORSHIP DEMOCRACIES OF WESTERN EUROPE AND LATIN AMERICA

2020 ◽  
Vol 24 (4) ◽  
pp. 942-964
Author(s):  
Alexey S. Koshel
Keyword(s):  
Latin America ◽  
Russian Federation ◽  
Western Europe ◽  
Parliamentary Democracy ◽  
Present Stage ◽  
The Russian Federation ◽  
Ongoing Development ◽  
Parliamentary Procedure

The article investigtes the powers and parliamentary procedures in the standing committees and commissions of several countries of Western Europe and Latin America. The author believes that one of the modern paradigms for the development of parliamentary democracy is to strengthen the role of standing committees in the work of parliament by transferring to the committee level a number of constitutional powers of parliaments. In this regard, the author clarifies approaches to the classification of the committee structure of parliaments and looks at committee parliamentary procedures in Italy, Germany, Greece, Portugal, Spain, Brazil and Argentina at the present stage. The author comes to certain conclusions regarding the paradigm of the committee parliamentary procedure, including further improvement of domestic constitutional-legal matter in the context of the ongoing development of parliamentary democracy in the Russian Federation.

scholarly journals La violencia homicida en América Latina

2009 ◽  
Vol 50 ◽  
Author(s):  
Roberto Briceño-León
Keyword(s):  
Latin America ◽  
Latin American ◽  
World Health ◽  
Data Bases ◽  
Homicide Rates ◽  
Social Classification ◽  
America Latina ◽  
Health Organization ◽  
Latin American Countries

RESUMEN: El artículo analiza la situación de la violencia homicida en América Latina, cuál es su ubicación en la situación mundial de violencia y cuáles serían las posibles explicaciones para el lugar que ocupa. Utilizando la base de datos de la Organización Mundial de la Salud se clasifican las regiones por su tasa de homicidios y se ubica a América Latina como la región más violenta. Los países de América Latina son clasificados en cuatro grupos de acuerdo a la relación de su tasa de homicidios con la tasa media mundial y se caracterizan socialmente las víctimas.Para interpretar esa situación se relacionan con los niveles de urbanización y pobreza y se presentan los factores que pueden originar, fomentar y facilitar el incremento o disminución de los homicidios y su potencial utilidad en las políticas públicas.ABSTRACT: This article explores the situation of homicide violence in Latin America, its position within the worlds violence situation and the possible explanations for that position. Using the data bases of the World Health Organization, regions are classified by their homicide rates, which puts Latin America as the most violent region. Latin American countries are set in four groups according to the relation of their homicide rates with the world’s rate, and a social classification of victims is built. For interpreting this situation, those factors are put in relation with the levels of urbanization and poverty, and the possible causes of the increase or decrease of homicides are presented, as well as their potential utility for public policy making.

LatamCovidNewsCheck. Meta-classification of Fact Checking Platforms in Latin America During the Covid-19 Pandemic

2021 ◽  
pp. 104-113
Author(s):  
Ignacio Balcázar ◽  
Angel Torres-Toukoumidis ◽  
Gabriela Balcazar
Keyword(s):  
Latin America ◽  
Fact Checking

scholarly journals Correction: Materials space of solid-state electrolytes: unraveling chemical composition–structure–ionic conductivity relationships in garnet-type metal oxides using cheminformatics virtual screening approaches

2020 ◽  
Vol 22 (26) ◽  
pp. 15058-15058
Author(s):  
Natalia Kireeva ◽  
Vladislav S. Pervov
Keyword(s):  
Chemical Composition ◽  
Solid State ◽  
Ionic Conductivity ◽  
Virtual Screening ◽  
Metal Oxides ◽  
Chem Phys ◽  
Solid State Electrolytes ◽  
Composition Structure ◽  
Screening Approaches ◽  
Phys Chem Chem Phys

Correction for ‘Materials space of solid-state electrolytes: unraveling chemical composition–structure–ionic conductivity relationships in garnet-type metal oxides using cheminformatics virtual screening approaches’ by Natalia Kireeva et al., Phys. Chem. Chem. Phys., 2017, 19, 20904–20918, DOI: 10.1039/c7cp00518k.

Discovery of new AKT1 inhibitors by combination of in silico structure based virtual screening approaches and biological evaluations

2020 ◽  
Vol 39 (1) ◽  
pp. 368-377 ◽  
Author(s):  
Filip Fratev ◽  
Denisse A. Gutierrez ◽  
Renato J. Aguilera ◽  
Ashish Tyagi ◽  
Chendil Damodaran ◽  
...  
Keyword(s):  
Virtual Screening ◽  
In Silico ◽  
Screening Approaches
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