Potential Cancer Biomarkers

2022 ◽  
pp. 160-174
Author(s):  
Fathima Mohammed Ahamed ◽  
Asiya Nazir
Keyword(s):  
Cancer Research ◽  
Cancer Screening ◽  
Cancer Biomarkers ◽  
Metabolic Effects ◽  
Integrative Approach ◽  
Molecular Characteristics ◽  
Clinical Validation ◽  
Epigenetic Alterations ◽  
Potential Cancer ◽  
Potential Biomarkers

Extensive studies in the field of oncology are able to identify potential cancer biomarkers with tumor-specific molecular characteristics that exceed or complement those of existing biomarkers. However, there are challenges in the development and clinical validation of the cancer biomarkers due to the complexity of the biological process involved. Standalone or integrative approach of broad range of biomolecules, their expression pattern, epigenetic alterations, and metabolic effects are well studied in the cancer research. The potential cancer biomarkers need to be studied extensively with advanced technologies to bring about a great change in cancer screening and therapy. This chapter provide an overview on recent studies about potential cancer biomarkers. Also, specific characteristics of potential biomarkers in three common types of cancer are discussed.

scholarly journals Lectins: an effective tool for screening of potential cancer biomarkers

2017 ◽  
Author(s):  
Onn Haji Hashim ◽  
Jaime Jacqueline Jayapalan ◽  
Cheng-Siang Lee
Keyword(s):  
Mass Spectrometry ◽  
Cancer Research ◽  
Cancer Patients ◽  
Structural Changes ◽  
Biomarker Discovery ◽  
Cancer Biomarkers ◽  
Bodily Fluids ◽  
Discovery Research ◽  
Potential Cancer ◽  
Potential Biomarkers

In recent years, the use of lectins for screening of potential biomarkers has gained increased importance in cancer research, given the development in glycobiology that highlights altered structural changes of glycans in cancer associated processes. Lectins, having the properties of recognizing specific carbohydrate moieties of glycoconjugates, have become an effective tool for detection of new cancer biomarkers in complex bodily fluids and tissues. The specificity of lectins provides an added advantage of selecting peptides that are differently glycosylated and aberrantly expressed in cancer patients, many of which are not possibly detected using conventional methods because of their low abundance in bodily fluids. When coupled with mass spectrometry, research utilizing lectins, which are mainly from plants and fungi, has led to identification of numerous potential cancer biomarkers that may be used in the future. This article reviews lectin-based methods that are commonly adopted in cancer biomarker discovery research.

scholarly journals Lectins: an effective tool for screening of potential cancer biomarkers

PeerJ ◽  
2017 ◽  
Vol 5 ◽  
pp. e3784 ◽  
Author(s):  
Onn Haji Hashim ◽  
Jaime Jacqueline Jayapalan ◽  
Cheng-Siang Lee
Keyword(s):  
Mass Spectrometry ◽  
Cancer Research ◽  
Cancer Patients ◽  
Structural Changes ◽  
Biomarker Discovery ◽  
Cancer Biomarkers ◽  
Bodily Fluids ◽  
Discovery Research ◽  
Potential Cancer ◽  
Potential Biomarkers

In recent years, the use of lectins for screening of potential biomarkers has gained increased importance in cancer research, given the development in glycobiology that highlights altered structural changes of glycans in cancer associated processes. Lectins, having the properties of recognizing specific carbohydrate moieties of glycoconjugates, have become an effective tool for detection of new cancer biomarkers in complex bodily fluids and tissues. The specificity of lectins provides an added advantage of selecting peptides that are differently glycosylated and aberrantly expressed in cancer patients, many of which are not possibly detected using conventional methods because of their low abundance in bodily fluids. When coupled with mass spectrometry, research utilizing lectins, which are mainly from plants and fungi, has led to identification of numerous potential cancer biomarkers that may be used in the future. This article reviews lectin-based methods that are commonly adopted in cancer biomarker discovery research.

scholarly journals Lectins: an effective tool for screening of potential cancer biomarkers

2017 ◽  
Author(s):  
Onn Haji Hashim ◽  
Jaime Jacqueline Jayapalan ◽  
Cheng-Siang Lee
Keyword(s):  
Mass Spectrometry ◽  
Cancer Research ◽  
Cancer Patients ◽  
Structural Changes ◽  
Biomarker Discovery ◽  
Cancer Biomarkers ◽  
Bodily Fluids ◽  
Discovery Research ◽  
Potential Cancer ◽  
Potential Biomarkers

In recent years, the use of lectins for screening of potential biomarkers has gained increased importance in cancer research, given the development in glycobiology that highlights altered structural changes of glycans in cancer associated processes. Lectins, having the properties of recognizing specific carbohydrate moieties of glycoconjugates, have become an effective tool for detection of new cancer biomarkers in complex bodily fluids and tissues. The specificity of lectins provides an added advantage of selecting peptides that are differently glycosylated and aberrantly expressed in cancer patients, many of which are not possibly detected using conventional methods because of their low abundance in bodily fluids. When coupled with mass spectrometry, research utilizing lectins, which are mainly from plants and fungi, has led to identification of numerous potential cancer biomarkers that may be used in the future. This article reviews lectin-based methods that are commonly adopted in cancer biomarker discovery research.

scholarly journals The Detection and Bioinformatic Analysis of Alternative 3′ UTR Isoforms as Potential Cancer Biomarkers

2021 ◽  
Vol 22 (10) ◽  
pp. 5322
Author(s):  
Nitika Kandhari ◽  
Calvin A. Kraupner-Taylor ◽  
Paul F. Harrison ◽  
David R. Powell ◽  
Traude H. Beilharz
Keyword(s):  
Gene Expression ◽  
Cell Transformation ◽  
Alternative Polyadenylation ◽  
Cancer Biomarkers ◽  
Bioinformatic Analysis ◽  
Alternative Transcript ◽  
Clinical Parameters ◽  
Transcript Cleavage ◽  
Cleavage And Polyadenylation ◽  
Potential Cancer

Alternative transcript cleavage and polyadenylation is linked to cancer cell transformation, proliferation and outcome. This has led researchers to develop methods to detect and bioinformatically analyse alternative polyadenylation as potential cancer biomarkers. If incorporated into standard prognostic measures such as gene expression and clinical parameters, these could advance cancer prognostic testing and possibly guide therapy. In this review, we focus on the existing methodologies, both experimental and computational, that have been applied to support the use of alternative polyadenylation as cancer biomarkers.

Systematic pan-cancer characterization of nuclear receptors identifies potential cancer biomarkers and therapeutic targets

2021 ◽  
pp. canres.3458.2020
Author(s):  
Junjie Jiang ◽  
Jiao Yuan ◽  
Zhongyi Hu ◽  
Mu Xu ◽  
Youyou Zhang ◽  
...  
Keyword(s):  
Nuclear Receptors ◽  
Therapeutic Targets ◽  
Cancer Biomarkers ◽  
Pan Cancer ◽  
Potential Cancer

scholarly journals Development of Data Infrastructure to Monitor Lung Cancer Screening Use and Outcomes in Four Cancer Research Network Sites

2016 ◽  
Vol 3 (3) ◽  
pp. 172
Author(s):  
V. Paul Doria-Rose ◽  
Lori C Sadoka ◽  
Christine M Neslund-Dudas ◽  
Debra P Ritzwoller ◽  
Heather S Feigelson ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Cancer Research ◽  
Cancer Screening ◽  
Lung Cancer Screening ◽  
Research Network ◽  
Cancer Research Network ◽  
Data Infrastructure

The Leeuwenhoek Lecture, 1978 Bacteria as proper subjects for cancer research

1980 ◽  
Vol 208 (1171) ◽  
pp. 121-133 ◽  
Keyword(s):  
Gene Expression ◽  
Stem Cells ◽  
Cancer Research ◽  
Mammalian Cells ◽  
Cell Renewal ◽  
Epigenetic Alterations ◽  
Cell Lineages ◽  
Abnormal Cells ◽  
Kinetics Of

Cancers are clones of abnormal cells, arising presumably as the result of mutational or epigenetic alterations of gene expression. The kinetics of appearance of spontaneous cancers in populations of multiplying cells (i. e. the relation between age and cancer incidence) will therefore depend, among other things, on how these populations are organized and, in general, on the kinetics of the response of cells to prolonged mutagenesis. The organization of cell renewal in epithelia (i. e. the arrangement of cell lineages) is still rather obscure; in particular, it is not known to what extent the properties and organization of the stem cells tend to protect them from accumulating mutations. We have tried to mimic the arrangement of epithelia by attaching multiplying bacteria to filters. Study of mutagenesis in long-term cultures of such anchored bacteria has led to the discovery of some additional pathways for DNA repair which also appear to operate in mammalian cells.

Amplified suspension magnetic bead-based assay for sensitive detection of anti-glycan antibodies as potential cancer biomarkers

2022 ◽  
pp. 339444
Author(s):  
Anna Blsakova ◽  
Filip Květoň ◽  
Lenka Lorencová ◽  
Ola Blixt ◽  
Alica Vikartovska ◽  
...  
Keyword(s):  
Cancer Biomarkers ◽  
Magnetic Bead ◽  
Sensitive Detection ◽  
Potential Cancer

Serum proteomic-based analysis of pancreatic carcinoma for the identification of potential cancer biomarkers

2007 ◽  
Vol 1774 (6) ◽  
pp. 764-771 ◽  
Author(s):  
Zhi-Ling Sun ◽  
Yi Zhu ◽  
Fu-Qiang Wang ◽  
Rui Chen ◽  
Tao Peng ◽  
...  
Keyword(s):  
Pancreatic Carcinoma ◽  
Cancer Biomarkers ◽  
Potential Cancer
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