Photoacoustic imaging (also called optoacoustic or thermoacoustic imaging) can image
vascularity clearly with simultaneous high contrast and high spatial resolution, and has the potential
to be an application for tumor diagnosis and treatment monitoring. In a unique photoacoustic
system, a single pulse laser beam was used as the light source for both cancer treatment and for
concurrently generating ultrasound signals for photoacoustic imaging. The photoacoustic system
was used to detect early tumor on the rat back, and the vascular structure around the tumor could be
imaged clearly with optimal contrast. This system was also used to monitoring damage of the
vascular structures before, during and after photodynamic therapy of tumor. This work
demonstrates that photoacoustic imaging can potentially be used to guide photodynamic therapy
and other phototherapies using vascular changes during treatment. Prospective application of
photoacoustic imaging is to characterize and monitor the accumulation of gold nanoshells in vivo to
guide nanoshell-based thermal tumor therapy.
This review summarizes the recent advances of tumor microenvironment-activated NIR-II agents for tumor diagnosis and treatment, including smart NIR-II fluorescence imaging, photoacoustic imaging, photothermal therapy and photodynamic therapy.
During the last 100 years, musculoskeletal radiology has developed from bone-only radiography performed by everyone to a dedicated subspecialty, still secure in its origins in radiography but having expanded into all modalities of imaging. Like other subspecialties in radiology, it has become heavily dependent on cross-sectional and functional imaging, and musculoskeletal interventions play an important role in tumor diagnosis and treatment and in joint diseases. All these developments are reflected in the pages in Acta Radiologica, as shown in this review.
Next-Generation Sequencing in Tumor Diagnosis and Treatment