Photoacoustic Imaging Application in Tumor Diagnosis and Treatment Monitoring

2007 ◽  
Vol 364-366 ◽  
pp. 1100-1104 ◽  
Author(s):  
Liang Zhong Xiang ◽  
Fei Fan Zhou
Keyword(s):  
Photodynamic Therapy ◽  
Photoacoustic Imaging ◽  
Tumor Therapy ◽  
Single Pulse ◽  
Treatment Monitoring ◽  
Tumor Diagnosis ◽  
Diagnosis And Treatment ◽  
Imaging Application ◽  
Early Tumor

Photoacoustic imaging (also called optoacoustic or thermoacoustic imaging) can image vascularity clearly with simultaneous high contrast and high spatial resolution, and has the potential to be an application for tumor diagnosis and treatment monitoring. In a unique photoacoustic system, a single pulse laser beam was used as the light source for both cancer treatment and for concurrently generating ultrasound signals for photoacoustic imaging. The photoacoustic system was used to detect early tumor on the rat back, and the vascular structure around the tumor could be imaged clearly with optimal contrast. This system was also used to monitoring damage of the vascular structures before, during and after photodynamic therapy of tumor. This work demonstrates that photoacoustic imaging can potentially be used to guide photodynamic therapy and other phototherapies using vascular changes during treatment. Prospective application of photoacoustic imaging is to characterize and monitor the accumulation of gold nanoshells in vivo to guide nanoshell-based thermal tumor therapy.

Tumor microenvironment-activated NIR-II reagents for tumor imaging and therapy

2020 ◽  
Vol 8 (22) ◽  
pp. 4738-4747 ◽  
Author(s):  
Xue Zhang ◽  
Lu An ◽  
Qiwei Tian ◽  
Jiaomin Lin ◽  
Shiping Yang
Keyword(s):  
Photodynamic Therapy ◽  
Tumor Microenvironment ◽  
Fluorescence Imaging ◽  
Photothermal Therapy ◽  
Tumor Imaging ◽  
Photoacoustic Imaging ◽  
Tumor Diagnosis ◽  
Diagnosis And Treatment ◽  
Recent Advances

This review summarizes the recent advances of tumor microenvironment-activated NIR-II agents for tumor diagnosis and treatment, including smart NIR-II fluorescence imaging, photoacoustic imaging, photothermal therapy and photodynamic therapy.

Jellyfish Sting—In Vivo Imaging for Diagnosis and Treatment Monitoring

2020 ◽  
Vol 156 (3) ◽  
pp. 348
Author(s):  
Alessandro Di Stefani ◽  
Simone Cappilli ◽  
Ketty Peris
Keyword(s):  
In Vivo Imaging ◽  
Treatment Monitoring ◽  
Diagnosis And Treatment

Photostable Iridium(III)–Cyanine Complex Nanoparticles for Photoacoustic Imaging Guided Near-Infrared Photodynamic Therapy in Vivo

2019 ◽  
Vol 11 (17) ◽  
pp. 15417-15425 ◽  
Author(s):  
Qi Yang ◽  
Hongyu Jin ◽  
Yucong Gao ◽  
Jiaomin Lin ◽  
Hong Yang ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Near Infrared ◽  
Photoacoustic Imaging

scholarly journals Assessment of the Theranostic Potential of Gold Nanostars—A Multimodal Imaging and Photothermal Treatment Study

Nanomaterials ◽  
2020 ◽  
Vol 10 (11) ◽  
pp. 2112 ◽  
Author(s):  
Antoine D’Hollander ◽  
Greetje Vande Velde ◽  
Hilde Jans ◽  
Bram Vanspauwen ◽  
Elien Vermeersch ◽  
...  
Keyword(s):  
Near Infrared ◽  
Tumor Imaging ◽  
Photoacoustic Imaging ◽  
Tumor Therapy ◽  
Infrared Region ◽  
Tumor Cell Death ◽  
Gold Nanostars ◽  
Theranostic Agents

Gold nanoparticles offer the possibility to combine both imaging and therapy of otherwise difficult to treat tumors. To validate and further improve their potential, we describe the use of gold nanostars that were functionalized with a polyethyleneglycol-maleimide coating for in vitro and in vivo photoacoustic imaging (PAI), computed tomography (CT), as well as photothermal therapy (PTT) of cancer cells and tumor masses, respectively. Nanostar shaped particles show a high absorption coefficient in the near infrared region and have a hydrodynamic size in biological medium around 100 nm, which allows optimal intra-tumoral retention. Using these nanostars for in vitro labeling of tumor cells, high intracellular nanostar concentrations could be achieved, resulting in high PAI and CT contrast and effective PTT. By injecting the nanostars intratumorally, high contrast could be generated in vivo using PAI and CT, which allowed successful multi-modal tumor imaging. PTT was successfully induced, resulting in tumor cell death and subsequent inhibition of tumor growth. Therefore, gold nanostars are versatile theranostic agents for tumor therapy.

scholarly journals Spatiotemporally controlled O2 and singlet oxygen self-sufficient nanophotosensitizers enable the in vivo high-yield synthesis of drugs and efficient hypoxic tumor therapy

2020 ◽  
Vol 11 (33) ◽  
pp. 8817-8827 ◽  
Author(s):  
Suisui He ◽  
Siyu Lu ◽  
Sha Liu ◽  
Tianrong Li ◽  
Jieling Li ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Singlet Oxygen ◽  
Tumor Therapy ◽  
High Yield ◽  
Drug Synthesis ◽  
Hypoxic Tumor

A porous photosensitizer displaying catalase-like activity and drug synthesis ability was synthesized for the synergistic chemo-photodynamic therapy, opening new promising ways for carrying out the precise cooperative treatment of hypoxic tumors.

scholarly journals Dual-Agent Photodynamic Therapy with Optical Clearing Eradicates Pigmented Melanoma in Preclinical Tumor Models

Cancers ◽  
2020 ◽  
Vol 12 (7) ◽  
pp. 1956 ◽  
Author(s):  
Layla Pires ◽  
Valentin Demidov ◽  
Brian C. Wilson ◽  
Ana Gabriela Salvio ◽  
Lilian Moriyama ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Photoacoustic Imaging ◽  
Critical Role ◽  
Tumor Model ◽  
Optical Clearing ◽  
Treatment Regimes ◽  
Pigmented Lesions ◽  
Melanoma Model

Treatment using light-activated photosensitizers (photodynamic therapy, PDT) has shown limited efficacy in pigmented melanoma, mainly due to the poor penetration of light in this tissue. Here, an optical clearing agent (OCA) was applied topically to a cutaneous melanoma model in mice shortly before PDT to increase the effective treatment depth by reducing the light scattering. This was used together with cellular and vascular-PDT, or a combination of both. The effect on tumor growth was measured by longitudinal ultrasound/photoacoustic imaging in vivo and by immunohistology after sacrifice. In a separate dorsal window chamber tumor model, angiographic optical coherence tomography (OCT) generated 3D tissue microvascular images, enabling direct in vivo assessment of treatment response. The optical clearing had minimal therapeutic effect on the in control, non-pigmented cutaneous melanomas but a statistically significant effect (p < 0.05) in pigmented lesions for both single- and dual-photosensitizer treatment regimes. The latter enabled full-depth eradication of tumor tissue, demonstrated by the absence of S100 and Ki67 immunostaining. These studies are the first to demonstrate complete melanoma response to PDT in an immunocompromised model in vivo, with quantitative assessment of tumor volume and thickness, confirmed by (immuno) histological analyses, and with non-pigmented melanomas used as controls to clarify the critical role of melanin in the PDT response. The results indicate the potential of OCA-enhanced PDT for the treatment of pigmented lesions, including melanoma.

Folate Conjugated CdHgTe Quantum Dots with High Targeting Affinity and Sensitivity for In vivo Early Tumor Diagnosis

2010 ◽  
Vol 21 (2) ◽  
pp. 793-801 ◽  
Author(s):  
Haiyan Chen ◽  
Li Li ◽  
Sisi Cui ◽  
Dider Mahounga ◽  
Jun Zhang ◽  
...  
Keyword(s):  
Quantum Dots ◽  
Tumor Diagnosis ◽  
Early Tumor

scholarly journals Spaser as a biological probe

2017 ◽  
Vol 8 (1) ◽  
Author(s):  
Ekaterina I. Galanzha ◽  
Robert Weingold ◽  
Dmitry A. Nedosekin ◽  
Mustafa Sarimollaoglu ◽  
Jacqueline Nolan ◽  
...  
Keyword(s):  
Cell Biology ◽  
Photoacoustic Imaging ◽  
Single Pulse ◽  
Spectral Width ◽  
Stimulated Emission ◽  
Water Soluble ◽  
Lasing Regime ◽  
Biological Probe

Abstract Understanding cell biology greatly benefits from the development of advanced diagnostic probes. Here we introduce a 22-nm spaser (plasmonic nanolaser) with the ability to serve as a super-bright, water-soluble, biocompatible probe capable of generating stimulated emission directly inside living cells and animal tissues. We have demonstrated a lasing regime associated with the formation of a dynamic vapour nanobubble around the spaser that leads to giant spasing with emission intensity and spectral width >100 times brighter and 30-fold narrower, respectively, than for quantum dots. The absorption losses in the spaser enhance its multifunctionality, allowing for nanobubble-amplified photothermal and photoacoustic imaging and therapy. Furthermore, the silica spaser surface has been covalently functionalized with folic acid for molecular targeting of cancer cells. All these properties make a nanobubble spaser a promising multimodal, super-contrast, ultrafast cellular probe with a single-pulse nanosecond excitation for a variety of in vitro and in vivo biomedical applications.

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