Association of Polymorphism rs1333049 with Risk of Gout

2013 ◽  
Vol 380-384 ◽  
pp. 4167-4169
Author(s):  
Qing Yao Wang ◽  
Hui Yong Yang

Background: Several independent studies have previously demonstrated an association of some polymorphisms in 9p21 locus with coronary risk disease. So this study aimed to evalute whether the SNP rs1333049 in 9p21 locus influenced susceptibility of gout which has been described as a risk factors for coronary heart disease. Methods: One case-control study was performed consisting of 20 healthy participants and 20 patients with gout. Statistical analysis was performed by software SPSS 16.0 afer genotyping with AS-PCR method. Results: The the cases and controls were in conformity with the Hardy-Weinberg law. The genotypes and alleles in this site was no diffence between the cases and the controls. Conclusions: The number of samples is critical for statistical analysis. It is necessary to study larger samples to get small infinite errors in results.

2000 ◽  
Vol 151 (1) ◽  
pp. 243
Author(s):  
B. Zyriax ◽  
H. Boeing ◽  
R. Fischer ◽  
P. Nielsen ◽  
E. Windler

2016 ◽  
Vol 13 (1) ◽  
pp. 401-406 ◽  
Author(s):  
Javad Ramezani ◽  
Toktam Moghiman ◽  
Farahzad Azad ◽  
Ghazal Ghasemi ◽  
Mahnaz Ahmadi ◽  
...  

2021 ◽  
Vol 28 (Supplement_1) ◽  
Author(s):  
F Ghaddar ◽  
RK Zeidan ◽  
P Salameh ◽  
S Tatari ◽  
G Achkouty ◽  
...  

Abstract Funding Acknowledgements Type of funding sources: Private grant(s) and/or Sponsorship. Main funding source(s): Medilab SARL Backgroung Given the expected epidemic rise of coronary heart disease (CHD) in healthcare system and the potential severity of disease, CHD remains underestimated in women. Early identification of risk factors (RFs) will be important for their health promotion. Purpose The aim of this study is to evaluate the RFs for CHD among Lebanese women aged 40 years and above. Methods A case-control study was carried out in 6 hospitals in the regions of Beirut and Mount-Lebanon, from December 2018 to December 2019 with a total of 1500 patients. Anthropometric and laboratory data were collected from the medical records of patients and structured questionnaire were used. Results CHD was positively associated with hyperlipidemia (aOR 2.852, 95% CI: 2.021–4.023), hypertension (2.715, 1.598–4.614), family history of CHD (2.645, 1.925–3.634), smoking (1.888, 1.393–2.558) and interestingly presence of joint pain (1.513, 1.107–2.068). While, residence in Mount-Lebanon seemed negatively associated with CHD (0.669, 0.467–0.959), as well as adherence to Mediterranean diet (0.964, 0.938–0.992) and physical activity (0.491, 0.259–0.930 and 0.718, 0.530–0.972, for high and moderate activity, respectively). Conclusion In our study, most of RFs associated with CHD in women are modifiable and preventable, highlighting the need of lifestyle interventions and appropriate control strategies and measures.


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