Fabrication of NF-PLLA Scaffolds by Gel Extraction Phase Separation

2014 ◽  
Vol 1033-1034 ◽  
pp. 1090-1093
Author(s):  
Zhi Hang He ◽  
Jia Liu ◽  
Guo Jie Xu ◽  
Jian Jin Jiao ◽  
Xiu Feng Xiao
Keyword(s):  
Phase Separation ◽  
Bone Tissue ◽  
Mixed Solvent ◽  
Solvent System ◽  
Separation Method ◽  
Interconnected Network ◽  
Nanofibrous Scaffolds ◽  
And Performance ◽  
Gel Temperature ◽  
Extraction Phase

The 1, 4-dioxane/ethanol mixed solvent was used as solvent system, and the gel extraction phase separation method was adopted to prepare porous PLLA nanofibrous scaffolds. At that, we studied the effect of using different gel temperature to influence nanofibrous PLLA scaffolds’ structure and performance. The results showed that the morphology of nanofibers and the diameter of fibers could be regulated by gel temperature; a lower gel temperature resulted in higher crystallinity of PLLA scaffold. In addition, the PLLA scaffolds have excellent interconnected network when the gel temperature was in the range of-20 to-10°C. The PLLA scaffolds will become a material to repair the bone tissue, hopefully.

Nanoporous polyethersulfone membranes prepared by mixed solvent phase separation method for protein separation

2021 ◽  
pp. 119507
Author(s):  
Peipei Li ◽  
Roshni L. Thankamony ◽  
Xiang Li ◽  
Zhen Li ◽  
Xiaowei Liu ◽  
...  
Keyword(s):  
Phase Separation ◽  
Protein Separation ◽  
Mixed Solvent ◽  
Separation Method ◽  
Solvent Phase

Fabrication of PLA Nanoporous Fibers by DMF/CF Mixed Solvent via Electrospinning

2014 ◽  
Vol 941-944 ◽  
pp. 400-403 ◽  
Author(s):  
Xiao Peng Tang ◽  
Lan Xu ◽  
Hong Ying Liu ◽  
Na Si
Keyword(s):  
Phase Separation ◽  
Specific Surface ◽  
Surface Area ◽  
Specific Surface Area ◽  
Convenient Method ◽  
Mixed Solvent ◽  
Solvent System ◽  
Polymer Fibers ◽  
Nanoporous Surface ◽  
Scanning Electron

Electrospinning represents a simple and convenient method for generating polymer fibers has been widely applied to produce porous nanofibers. The PLA fibers obtained in this research showed a significant nanoporous surface by varying solvent compositions of chloroform (CF) and N,N-dimethylformamide (DMF).The nanopores produced by phase separation of solvent system were observed by means of scanning electron microscope.The approach showed the fabrication of electrospun nanoporous fibers possessing ultrahigh specific surface area without any post-treatment.

Phase separation and heat-induced gelation characteristics of cellulose acetate in a mixed solvent system

Cellulose ◽  
2010 ◽  
Vol 17 (3) ◽  
pp. 533-538 ◽  
Author(s):  
Collins Appaw ◽  
Richard D. Gilbert ◽  
Saad A. Khan ◽  
John F. Kadla
Keyword(s):  
Phase Separation ◽  
Cellulose Acetate ◽  
Mixed Solvent ◽  
Solvent System ◽  
Mixed Solvent System

Phase separation in sol gel-derived ceramic films of silica-zirconia, alumina-zirconia, and titania-zirconia system

1994 ◽  
Vol 52 ◽  
pp. 646-647
Author(s):  
J. Tong ◽  
L. Eyring
Keyword(s):  
Fracture Toughness ◽  
Phase Separation ◽  
Sol Gel ◽  
Great Influence ◽  
High Strength ◽  
Chemical Durability ◽  
Separation Method ◽  
Toughening Mechanism ◽  
Ceramic Films ◽  
Zirconia Toughened Alumina

There is increasing interest in composites containing zirconia because of their high strength, fracture toughness, and its great influence on the chemical durability in glass. For the zirconia-silica system, monolithic glasses, fibers and coatings have been obtained. There is currently a great interest in designing zirconia-toughened alumina including exploration of the processing methods and the toughening mechanism.The possibility of forming nanocrystal composites by a phase separation method has been investigated in three systems: zirconia-alumina, zirconia-silica and zirconia-titania using HREM. The morphological observations initially suggest that the formation of nanocrystal composites by a phase separation method is possible in the zirconia-alumina and zirconia-silica systems, but impossible in the zirconia-titania system. The separation-produced grain size in silica-zirconia system is around 5 nm and is more uniform than that in the alumina-zirconia system in which the sizes of the small polyhedron grains are around 10 nm. In the titania-zirconia system, there is no obvious separation as was observed in die alumina-zirconia and silica-zirconia system.

scholarly journals FORMULATION AND IN VITRO, IN VIVO EVALUATION OF PRONIOSOMAL GEL OF NEOMYCIN SULPHATE

2019 ◽  
pp. 156-163
Author(s):  
AMOL SHETE ◽  
PRIYANKA THORAT ◽  
RAJENDRA DOIJAD ◽  
SACHIN SAJANE
Keyword(s):  
Phase Separation ◽  
Skin Irritation ◽  
Entrapment Efficiency ◽  
Separation Method ◽  
Gelling Agent ◽  
In Vivo Evaluation ◽  
Skin Delivery ◽  
Span 60

Objective: The objectives of present investigation were to prepare and evaluate proniosomes of neomycin sulphate (NS) by coacervation phase separation method by using sorbitan monostearate (span 60) and lecithin as a surfactant to increase the penetration through the skin and study the effect of concentration of the same. Methods: Proniosomes of neomycin sulphate (NS) were prepared by coacervation phase separation method by using span 60 and lecithin. The effect of concentration of span 60 and lecithin was studied by factorial design. The prepared proniosomes were converted to gel by using carbopol as a gelling agent. The prepared formulations were evaluated for entrapment efficiency, in vitro drug diffusion, in vitro antibacterial activity and in vivo skin irritation test etc. Results: All Formulation showed the percentage entrapment efficiency in the range 38.31±0.05% to 77.96±0.06%, good homogeneity and gel was easily spreadable with minimal of shear. Optimized formulation showed enhanced rate of diffusion in vitro, increase in zone of inhibition against staphylococcus aureus, no skin irritation and showed good stability. Conclusion: The results of present study indicates that proniosomal gel formulated by using combination of span 60, Lecithin, cholesterol can be used to enhance skin delivery of NS because of excellent permeation of drug. Developed proniosomal gel formulation was promising carrier for NS

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