Neutron and Neutron-Photon Therapy for Head and Neck Cancer

2015 ◽  
Vol 1084 ◽  
pp. 409-412
Author(s):  
Olga Gribova ◽  
Ludmila Musabaeva ◽  
Evgenij Choynzonov ◽  
Valerij Novikov
Keyword(s):  
Thyroid Gland ◽  
Long Term Results ◽  
Fast Neutrons ◽  
Salivary Gland Cancer ◽  
Combined Modality Treatment ◽  
Study Group ◽  
Combined Modality ◽  
Thyroid Gland Cancer ◽  
Radiotherapy Alone

The study group comprised 124 patients with salivary gland cancer and 46 patients with thyroid gland cancer who received the combined modality treatment and radiotherapy alone with the use of 6.3 MeV fast neutrons generated within U-120 cyclotron. The combined modality treatment and radiation therapy with the use of fast neutrons allow encouraging long-term results to be achieved for patients with salivary and thyroid gland cancers.

957 poster LONG TERM RESULTS FOR COMBINED MODALITY TREATMENT FOR ANAL CANCER

2011 ◽  
Vol 99 ◽  
pp. S365
Author(s):  
I. Oblak ◽  
P. Petric ◽  
A.L. Vodusek ◽  
V. Velenik ◽  
F. Anderluh ◽  
...  
Keyword(s):  
Anal Cancer ◽  
Long Term Results ◽  
Combined Modality Treatment ◽  
Combined Modality

Combined-Modality Therapy Versus Radiotherapy Alone for Treatment of Early-Stage Hodgkin's Disease: Cure Balanced Against Complications

2006 ◽  
Vol 24 (4) ◽  
pp. 605-611 ◽  
Author(s):  
Bridget F. Koontz ◽  
John P. Kirkpatrick ◽  
Robert W. Clough ◽  
Robert G. Prosnitz ◽  
Jon P. Gockerman ◽  
...  
Keyword(s):  
Hodgkin's Disease ◽  
Early Stage ◽  
Hodgkin’S Disease ◽  
Combined Modality Therapy ◽  
Long Term Results ◽  
Cardiac Complications ◽  
Second Malignancies ◽  
Combined Modality ◽  
Radiotherapy Alone

Purpose The treatment of early-stage Hodgkin's disease (HD) has evolved from radiotherapy alone (RT) to combined-modality therapy (CMT) because of concerns about late adverse effects from high-dose subtotal nodal irradiation (STNI). However, there is little information regarding the long-term results of CMT programs that substantially reduce the dose and extent of radiation. In addition, lowering the total radiation dose may reduce the complication rate without compromising cure. This retrospective study compares the long-term results of STNI with CMT using modestly reduced RT dose in the treatment of early-stage HD. Patients and Methods Between 1982 and 2002, 111 patients with stage IA and IIA HD were treated definitively with RT (mean dose, 37.9 Gy); 70 patients were treated with CMT with low-dose involved-field radiotherapy (LDIFRT; mean dose, 25.5 Gy). Median follow-up was 11.7 years for RT patients and 8.1 years for the CMT group. Results There was a trend toward improved 20-year overall survival with CMT (83% v 70%; P = .405). No second cancers were observed in the CMT group; in the RT group the actuarial frequency of a second cancer was 16% at 20 years. There was no difference in the frequency of cardiac complications (9% v 6%, RT v CMT). Conclusion In this retrospective review, CMT with LDIFRT was effective in curing early-stage HD and was not associated with an increase in second malignancies. For RT alone, a moderate dose seemed to reduce cardiac complications but did not lessen second malignancies compared with higher doses used historically.

Multimodality Treatment of Locally-Advanced Breast Cancer Using 6.3 MeV Fast Neutrons and Quality of Life in Patients in Long-Term Follow-Up

2015 ◽  
Vol 1084 ◽  
pp. 406-408
Author(s):  
Zhanna Startseva ◽  
Ludmila Musabaeva ◽  
Valerij Lisin
Keyword(s):  
Breast Cancer ◽  
Advanced Breast Cancer ◽  
Locally Advanced Breast Cancer ◽  
Locally Advanced ◽  
Multimodality Treatment ◽  
Advanced Breast ◽  
Long Term Results ◽  
Fast Neutrons ◽  
Combined Modality Treatment

The purpose of the study is to present the 10-year results of the combined modality treatment with the use of neutron-photon therapy for patients with T2-4N0-2M0 locally advanced breast cancer (LABC). The study involved 246 LABC patients (T2-4N0-2M0). Analysis of long-term results of multimodality treatment of patients with primary LABC has shown that preoperative neutron therapy is the most effective in the presence of multicentric tumors, radioresistance to neoadjuvant chemotherapy and other adverse prognostic factors.

Long-term results of combined modality treatment with I-125 implantation for carcinoma of the pancreas

1992 ◽  
Vol 23 (2) ◽  
pp. 305-311 ◽  
Author(s):  
Mohammed Mohiuddin ◽  
Francis Rosato ◽  
Donna Barbot ◽  
Alan Schuricht ◽  
William Biermann ◽  
...  
Keyword(s):  
Long Term Results ◽  
Combined Modality Treatment ◽  
Carcinoma Of The Pancreas ◽  
Combined Modality

Complete pathologic response after combined-modality treatment for rectal cancer and long-term survivals: A meta-analysis.

2011 ◽  
Vol 29 (4_suppl) ◽  
pp. 479-479 ◽  
Author(s):  
L. Zorcolo ◽  
A. S. Rosman ◽  
A. Restivo ◽  
M. Pisano ◽  
G. R. Nigri ◽  
...  
Keyword(s):  
Rectal Cancer ◽  
Meta Analysis ◽  
Neoadjuvant Chemoradiotherapy ◽  
Small Sample ◽  
Pathologic Response ◽  
Long Term Results ◽  
Combined Modality Treatment ◽  
Complete Pathologic Response ◽  
Combined Modality

479 Background: Recent literature suggests that a complete pathologic response (CPR) following neoadjuvant chemoradiotherapy (combined modality treatment, CMT) for rectal cancer is associated with improved survivals compared to partial or no response (NPR). However, previous reports have been limited by small sample size and single-institution design. To overcome these limitations, we performed a meta- analysis of studies evaluating the prognostic value of CPR. Methods: A systematic literature review was conducted to detect studies comparing long-term results of patients with CPR or NPR after CMT for rectal cancer. Variables were pooled only if evaluated by 3 or more studies. Both qualitative and quantitative data were pooled using a random-effects model. Study endpoints included rates of complete pathological response, local recurrence (LR), distant recurrence (DR), as well as 5-year overall (OS) and disease-free survival (DFS). Results: There were 13 studies suitable for the meta-analysis, that overall reported on outcomes of 2030 patient with rectal cancer treated with CMT. CPR was achieved in 332 patients (16.4%). CPR and NPR patients groups were similar with respect to age, male gender, tumor size, distance of tumor from the anus and pre- treatment stage (p > 0.3 for all comparisons). Median follow-up ranged from 23.5 to 46 months. CPR patients had lower rates of LR (0.7% vs. 2.6%; odds ratio [OR]=0.45, 95% CI 0.22–0.90), DR (5.3% vs. 24.1%; OR=0.15, 95% CI 0.07–0.31) and LR+DR (0.7% vs. 4.8%; OR=0.32, 95% CI 0.13–0.79). OS was 92.6% for CPR vs. 73.2% for NPR (OR=3.6, 95% CI 1.84–7.06), and DFS was 89.1% vs. 64.3% (OR=4.3, 95% CI 1.8-10.1). Conclusions: Our meta-analysis confirms that a CPR following CMT for rectal cancer is associated with an improved local and distal control as well enhanced OS and DFS. No significant financial relationships to disclose.

Long-term results after combined modality treatment for non-metastatic osteosarcoma

1999 ◽  
Vol 16 (4) ◽  
pp. 255-260 ◽  
Author(s):  
J Aparicio ◽  
A Segura ◽  
J Montalar ◽  
S Garcerá ◽  
A Oltra ◽  
...  
Keyword(s):  
Long Term Results ◽  
Combined Modality Treatment ◽  
Combined Modality ◽  
Metastatic Osteosarcoma

Combined-Modality Treatment and Selective Organ Preservation in Invasive Bladder Cancer: Long-Term Results

2002 ◽  
Vol 20 (14) ◽  
pp. 3061-3071 ◽  
Author(s):  
Claus Rödel ◽  
Gerhard G. Grabenbauer ◽  
Reinhard Kühn ◽  
Thomas Papadopoulos ◽  
Jürgen Dunst ◽  
...  
Keyword(s):  
Bladder Cancer ◽  
Early Stage ◽  
Long Term Results ◽  
Combined Modality Treatment ◽  
Disease Specific Survival ◽  
Bladder Preservation ◽  
Combined Modality ◽  
Disease Specific ◽  
Salvage Cystectomy

PURPOSE: To evaluate our long-term experience with combined modality treatment and selective bladder preservation and to identify factors that may predict treatment response, risk of relapse, and survival. PATIENTS AND METHODS: Between 1982 and 2000, 415 patients with bladder cancer (high-risk T1, n = 89; T2 to T4, n = 326) were treated with radiotherapy (RT; n = 126) or radiochemotherapy (RCT; n = 289) after transurethral resection (TUR) of the tumor. Six weeks after RT/RCT, response was evaluated by restaging-TUR. In case of complete response (CR), patients were observed at regular intervals. In case of persistent or recurrent invasive tumor, salvage-cystectomy was recommended. Median follow-up was 60 months (range, 6 to 199 months). RESULTS: CR was achieved in 72% of patients. Local control after CR without muscle-invasive relapse was maintained in 64% of patients at 10 years. Distant metastases were diagnosed in 98 patients with an actuarial rate of 35% at 10 years. Ten-year disease-specific survival was 42%, and more than 80% of survivors preserved their bladder. Early tumor stage and a complete TUR were the most important factors predicting CR and survival. RCT was more effective than RT alone in terms of CR and survival. Salvage cystectomy for local failure was associated with a 45% disease-specific survival rate at 10 years. Cystectomy because of a contracted bladder was restricted to 2% of patients. CONCLUSION: TUR with RCT is a reasonable option for patients seeking an alternative to radical cystectomy. Ideal candidates are those with early-stage and unifocal tumors, in whom a complete TUR is accomplished.

scholarly journals Role and effectiveness of complex and supervised rehabilitation on overall and hand function in systemic sclerosis patients—one-year follow-up study

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Michał Waszczykowski ◽  
Bożena Dziankowska-Bartkowiak ◽  
Michał Podgórski ◽  
Jarosław Fabiś ◽  
Arleta Waszczykowska
Keyword(s):  
Systemic Sclerosis ◽  
Hand Function ◽  
Exercise Program ◽  
Rehabilitation Program ◽  
Long Term Results ◽  
Home Exercise ◽  
Control Group ◽  
Study Group

AbstractThe aim of this study was to estimate the long-term results of complex and supervised rehabilitation of the hands in systemic sclerosis (SSc) patients. Fifty-one patients were enrolled in this study: 27 patients (study group) were treated with a 4-week complex, supervised rehabilitation protocol. The control group of 24 patients was prescribed a home exercise program alone. Both groups were evaluated at baseline and after 1-, 3-, 6-, and 12-months of follow-up with the Disability of the Arm, Shoulder and Hand Questionnaire (DAHS) as the primary outcome, pain (VAS—visual analog scale), Cochin Hand Function Scale (CHFS), Health Assessment Questionnaire Disability Index (HAQ-DI), Scleroderma-HAQ (SHAQ), range of motion (d-FTP—delta finger to palm, Kapandji finger opposition test) and hand grip and pinch as the secondary outcomes. Only the study group showed significant improvements in the DASH, VAS, CHFS and SHAQ after 1, 3 and 6 months of follow-up (P = 0.0001). Additionally, moderate correlations between the DASH, CHFS and SHAQ (R = 0.7203; R = 0.6788; P = 0.0001) were found. Complex, supervised rehabilitation improves hand and overall function in SSc patients up to 6 months after the treatment but not in the long term. The regular repetition of this rehabilitation program should be recommended every 3–6 months to maintain better hand and overall function.

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