The Role of Adhesion in Gold Nanoparticles for Cancer Detection and Treatment

2015 ◽  
Vol 1132 ◽  
pp. 72-86
Author(s):  
Y. Oni ◽  
J.D. Obayemi ◽  
K. Kao ◽  
S. Dozie-Nwachukwu ◽  
S. Odusanya ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Gold Nanoparticles ◽  
Cancer Cells ◽  
Cancer Detection ◽  
Breast Cancer Cells ◽  
Au Nanoparticle ◽  
Adhesion Forces ◽  
Force Microscopy ◽  
Nanoparticle Clusters ◽  
Potential Applications

This paper presents the results of an experimental study of the effects of adhesion between gold nanoparticles and surfaces that are relevant to the potential applications in cancer detection and treatment. Adhesion is measured using a dip coating/atomic force microscopy (DC/AFM) technique. The adhesion forces are obtained for dip-coated gold nanoparticles that interact with peptide or antibody-based molecular recognition units (MRUs) that attach specifically to breast cancer cells. They include MRUs that attach specifically to receptors on breast cancer cells. Adhesion forces between anti-cancer drugs such as paclitaxel, and the constituents of MRU-conjugated Au nanoparticle clusters, are measured using force microscopy techniques. The implications of the results are then discussed for the design of robust gold nanoparticle clusters and for potential applications in localized drug delivery and hyperthermia.

scholarly journals A rapid nanobiosensing platform based on herceptin-conjugated graphene for ultrasensitive detection of circulating tumor cells in early breast cancer

2021 ◽  
Vol 10 (1) ◽  
pp. 744-753
Author(s):  
Zahra Rahimzadeh ◽  
Seyed Morteza Naghib ◽  
Esfandyar Askari ◽  
Fatemeh Molaabasi ◽  
Ali Sadr ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Cells ◽  
Cancer Detection ◽  
Breast Cancer Cells ◽  
Graphene Nanosheets ◽  
Her2 Positive ◽  
Promising Candidate ◽  
Graphene Layers ◽  
The Stability ◽  
Positive Breast Cancer

Abstract In this paper, we use a simple and cheap approach for the synthesis of herceptin-conjugated graphene biosensor to detect the HER2-positive breast cancer cells. The bifunctional graphene-herceptin nanosheets are prepared from graphite by a simple ultrasonic-mediated technique. The prepared protein-mediated graphene is fully characterized. The results show the exfoliation of graphene layers in herceptin solution. Moreover, herceptin is effectively conjugated into the surface of graphene nanosheets. The synthesized herceptin-conjugated graphene is applied for breast cancer detection. The linear range of this biosensor is 1–80 cells, which is significant. The biosensor shows an excellent selectivity performance for detection of HER2-positive cancer cells. Likewise, the stability and functionality of the biosensor is about 40 days. Based on the results, this device is a promising candidate for rapid and selective detection of cancer cells.

Dragon fruit extract capped gold nanoparticles: Synthesis and their differential cytotoxicity effect on breast cancer cells

2019 ◽  
Vol 236 ◽  
pp. 498-502 ◽  
Author(s):  
Deepika Divakaran ◽  
Jaya R. Lakkakula ◽  
Mukeshchand Thakur ◽  
Mukesh Kumar Kumawat ◽  
Rohit Srivastava
Keyword(s):  
Breast Cancer ◽  
Gold Nanoparticles ◽  
Cancer Cells ◽  
Breast Cancer Cells ◽  
Fruit Extract ◽  
Dragon Fruit ◽  
Nanoparticles Synthesis

Molecularly targeted gold nanoparticles enhance the radiation response of breast cancer cells and tumor xenografts to X-radiation

2012 ◽  
Vol 137 (1) ◽  
pp. 81-91 ◽  
Author(s):  
Niladri Chattopadhyay ◽  
Zhongli Cai ◽  
Yongkyu Luke Kwon ◽  
Eli Lechtman ◽  
Jean-Philippe Pignol ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Gold Nanoparticles ◽  
Cancer Cells ◽  
Breast Cancer Cells ◽  
Radiation Response ◽  
Tumor Xenografts

Receptor-Mediated In Vivo Targeting of Breast Cancer Cells with 17α-Ethynylestradiol-Conjugated Silica-Coated Gold Nanoparticles

Langmuir ◽  
2020 ◽  
Vol 36 (48) ◽  
pp. 14819-14828
Author(s):  
Alexander M. Renner ◽  
Shaista Ilyas ◽  
Hans A. Schlößer ◽  
Annika Szymura ◽  
Stefan Roitsch ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Gold Nanoparticles ◽  
Cancer Cells ◽  
Breast Cancer Cells

scholarly journals Application of Gold Nanoparticles for Early Detection of Breast Cancer Cells

2011 ◽  
Vol 9 ◽  
pp. 544-547 ◽  
Author(s):  
Luu Manh Quynh ◽  
Tran Quoc Tuan ◽  
Nguyen Hoang Luong ◽  
Nguyen Ngoc Long ◽  
Nguyen Hoang Hai ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Gold Nanoparticles ◽  
Early Detection ◽  
Cancer Cells ◽  
Breast Cancer Cells

scholarly journals Cytotoxic Induction and Photoacoustic Imaging of Breast Cancer Cells Using Astaxanthin-Reduced Gold Nanoparticles

Nanomaterials ◽  
2016 ◽  
Vol 6 (4) ◽  
pp. 78 ◽  
Author(s):  
Subramaniyan Bharathiraja ◽  
Panchanathan Manivasagan ◽  
Nhat Quang Bui ◽  
Yun-Ok Oh ◽  
In Lim ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Gold Nanoparticles ◽  
Cancer Cells ◽  
Breast Cancer Cells ◽  
Photoacoustic Imaging
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