Enantiomeric Separation of 1-Phenyl-1-Propanol Using Calix[4]Arene-Capped β-Cyclodextrin-Bonded Silica Particles as Chiral Stationary Phase in Capillary Electrochromatography

2013 ◽  
Vol 749 ◽  
pp. 304-308 ◽  
Author(s):  
Jia Zhao ◽  
Jun Li ◽  
E.L. Yong ◽  
Yin Han Gong

A new type of calix [ arene-capped (3-(2-O-β-cyclodextrin)-2-hydroxypropoxy) propylsilyl-appended silica particles (C4CD-HPS) has been successfully used as chiral stationary phase (CSP) in capillary electrochromatography (CEC) for separation of enantiomers of 1-phenyl-1-propanol for the first time. C4CD-HPS contains a chiral selector with two recognition sites: calix [arene and β-cyclodextrin. Due to the cooperative functioning of the calix [arene and β-cyclodextrin, C4CD-HPS has exhibited excellent enantioselectivity for the enantiomers of 1-phenyl-1-propanol. After the multiple phenolic hydroxyl groups in the calix [arene moieties are ionized in the running buffer, the bonded stationary phase C4CD-HPS becomes negatively-charged to provide high electroosmotic flow (EOF) in CEC. Fast and high-resolution separation for enantiomers of 1-phenyl-1-propanol has been easily achieved on C4CD-HPS. This new type of chiral stationary phase has exhibited great potential for fast enantiomeric separations in CEC.

2007 ◽  
Vol 2 ◽  
pp. 117739010700200
Author(s):  
Ashraf Ghanem

Chirasil-β-Dex containing an undecamethylene spacer (C11-Chirasil-Dex) was synthesized and used as chiral stationary phase (CSP) in enantioselective gas chromatography (GC). The versatility of the new stationary phase in the simultaneous enantiomeric separation of a set of N-alkylated barbiturates is demonstrated.


2018 ◽  
Vol 42 (14) ◽  
pp. 11724-11731 ◽  
Author(s):  
Meng Li ◽  
Bo Zhang ◽  
Jia Yu ◽  
Jian Wang ◽  
Xingjie Guo

Enantiomeric separation process of anticholinergic drugs and chiral recognition mechanisms on Chiralpak ID column.


2015 ◽  
Vol 7 (19) ◽  
pp. 8227-8234 ◽  
Author(s):  
Xiu-Ju Li ◽  
Qi-Feng Fu ◽  
Qi-Hui Zhang ◽  
Xue-Mei Jiang ◽  
Feng-Qing Yang ◽  
...  

A novel method for the preparation of permanent coating columns with a high phase ratio based on the multiple properties of PDA and LBL self-assembly of polydopamine/gold nanoparticles/thiols has been developed for the first time.


1999 ◽  
Vol 63 (1) ◽  
pp. 18-23
Author(s):  
Kwang-Pill Lee ◽  
Hyun-Bong Lee ◽  
Young Cheol Lee ◽  
Seong-Ho Choi ◽  
Jae Jeong Ryoo ◽  
...  

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