Score Model Based on Forward-Reverse Databases for Phosphopeptides Identification

2014 ◽  
Vol 898 ◽  
pp. 827-830
Author(s):  
Xiao Zhou Chen
Keyword(s):  
Comparative Analysis ◽  
Database Searching ◽  
Strongly Correlated ◽  
Site Assessment ◽  
Identification Methods ◽  
Mascot Score ◽  
Building Models ◽  
Phosphorylated Peptides ◽  
Score Model

Identification of phosphorylated peptides takes into account factors relevant in matching, building models, and score algorithms. In the paper we make a detailed comparative analysis among various phosphorylation identification methods, and study current mainstream algorithms in database searching and identification, and compares various aspects and methods of algorithms in site assessment. Based on the theory of forward-reverse databases searching, It is proposed a new score model to ensure the quality of identification. Our result shows that PTM and Mascot score models were strongly correlated and complementated in their differentiation abilities. Therefore, PTM and Mascot score models can be combined to filter peptide.

Optimal Quality Control Based on Mascot and PTM Score Model for Phosphopeptides Identification

2014 ◽  
Vol 530-531 ◽  
pp. 185-188
Author(s):  
Xiao Zhou Chen
Keyword(s):  
Quality Control ◽  
Control Method ◽  
Database Searching ◽  
Phosphorylation Sites ◽  
Control Methods ◽  
Site Assessment ◽  
Quality Control Method ◽  
Score Model ◽  
Optimal Quality

There are currently various algorithms with mass spectrometry in phosphorylation identification. Some quality control methods have also been proposed. However, a detailed comparative analysis among various methods has not been reported. In the paper, based on the theory of forward-reverse databases searching, we compare current major algorithms in database searching and identification i.e Mascot and Sequest, and compare various aspects and methods of algorithms in site assessment. We propose an effictive quality control method. Our result shows that this method can ensure the quality of identification and identify more phosphorylation sites.

Assessment of the quality of opening of soil structures technical means developed in Kuban State Agrarian University

2020 ◽  
Author(s):  
B. F. Tarasenko B. F. ◽  
◽  
S. Y. Orlenko S. Y. ◽  
V. V. Kuzmin V. V.
Keyword(s):  
Comparative Analysis ◽  
Field Tests ◽  
Soil Structures ◽  
Improved Design

The article presents a comparative analysis, based on field tests, of the quality of loosening of soil structures of the upper horizon with technical means developed at KubSAU and an improved design of a universal tillage unit.

Comparative analysis of intelligent planning methods

2012 ◽  
Vol 9 (2) ◽  
pp. 53-57 ◽  
Author(s):  
O.V. Darintsev ◽  
A.B. Migranov
Keyword(s):  
Neural Networks ◽  
Genetic Algorithms ◽  
Fuzzy Logic ◽  
Comparative Analysis ◽  
Mobile Robots ◽  
Sensory Information ◽  
Working Environment ◽  
Planning Methods ◽  
Intelligent Planning

The main stages of solving the problem of planning movements by mobile robots in a non-stationary working environment based on neural networks, genetic algorithms and fuzzy logic are considered. The features common to the considered intellectual algorithms are singled out and their comparative analysis is carried out. Recommendations are given on the use of this or that method depending on the type of problem being solved and the requirements for the speed of the algorithm, the quality of the trajectory, the availability (volume) of sensory information, etc.

scholarly journals Comparative analysis of the microbial community and nutritional quality of sufu

2021 ◽  
Author(s):  
Xingjiang Li ◽  
Ying He ◽  
Wei Yang ◽  
Dongdong Mu ◽  
Min Zhang ◽  
...  
Keyword(s):  
Comparative Analysis ◽  
Microbial Community ◽  
Nutritional Quality

A comparative analysis of long range and NB-IoT in terms of quality of connectivity

2021 ◽  
Author(s):  
P. Yogendra Prasad ◽  
H. Heera ◽  
N. Padmaja ◽  
Bathala sony
Keyword(s):  
Comparative Analysis ◽  
Long Range

scholarly journals Residual Corticosteroid Production in Autoimmune Addison Disease

2020 ◽  
Vol 105 (7) ◽  
pp. 2430-2441
Author(s):  
Åse Bjorvatn Sævik ◽  
Anna-Karin Åkerman ◽  
Paal Methlie ◽  
Marcus Quinkler ◽  
Anders Palmstrøm Jørgensen ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Disease Duration ◽  
Plasma Renin ◽  
Serum Cortisol ◽  
Strongly Correlated ◽  
Cross Sectional ◽  
Addison Disease ◽  
Serum Aldosterone ◽  
Liquid Chromatography Tandem Mass

Abstract Context Contrary to current dogma, growing evidence suggests that some patients with autoimmune Addison disease (AAD) produce corticosteroids even years after diagnosis. Objective To determine frequencies and clinical features of residual corticosteroid production in patients with AAD. Design Two-staged, cross-sectional clinical study in 17 centers (Norway, Sweden, and Germany). Residual glucocorticoid (GC) production was defined as quantifiable serum cortisol and 11-deoxycortisol and residual mineralocorticoid (MC) production as quantifiable serum aldosterone and corticosterone after > 18 hours of medication fasting. Corticosteroids were analyzed by liquid chromatography–tandem mass spectrometry. Clinical variables included frequency of adrenal crises and quality of life. Peak cortisol response was evaluated by a standard 250 µg cosyntropin test. Results Fifty-eight (30.2%) of 192 patients had residual GC production, more common in men (n = 33; P < 0.002) and in shorter disease duration (median 6 [0-44] vs 13 [0-53] years; P < 0.001). Residual MC production was found in 26 (13.5%) patients and associated with shorter disease duration (median 5.5 [0.5-26.0] vs 13 [0-53] years; P < 0.004), lower fludrocortisone replacement dosage (median 0.075 [0.050-0.120] vs 0.100 [0.028-0.300] mg; P < 0.005), and higher plasma renin concentration (median 179 [22-915] vs 47.5 [0.6-658.0] mU/L; P < 0.001). There was no significant association between residual production and frequency of adrenal crises or quality of life. None had a normal cosyntropin response, but peak cortisol strongly correlated with unstimulated cortisol (r = 0.989; P < 0.001) and plasma adrenocorticotropic hormone (ACTH; r = –0.487; P < 0.001). Conclusion In established AAD, one-third of the patients still produce GCs even decades after diagnosis. Residual production is more common in men and in patients with shorter disease duration but is not associated with adrenal crises or quality of life.

244An automated beat exclusion algorithm to improve beat-to-beat P-wave morphology analysis

EP Europace ◽  
2020 ◽  
Vol 22 (Supplement_1) ◽  
Author(s):  
D Tachmatzidis ◽  
D Filos ◽  
I Chouvarda ◽  
A Tsarouchas ◽  
D Mouselimis ◽  
...  
Keyword(s):  
P Wave ◽  
Strongly Correlated ◽  
Wave Analysis ◽  
Morphology Analysis ◽  
Wave Morphology ◽  
History Of ◽  
Ectopic Beats ◽  
Rater Variability ◽  
Operator Workload

Abstract Background A manually beat-to-beat P-wave analysis has previously revealed the existence of multiple P-wave morphologies in patients with paroxysmal Atrial Fibrillation (AF) while on sinus rhythm, distinguishing them from healthy, AF free patients. Purpose The aim of this study was to investigate the effectiveness of an Automated Beat Exclusion algorithm (ABE) that excludes noisy or ectopic beats, replacing manual beat evaluation during beat-to-beat P-wave analysis, by assessing its effect on inter-rater variability and reproducibility. Methods Beat-to-beat P-wave morphology analysis was performed on 34 ten-minute ECG recordings of patients with a history of AF. Each recording was analyzed independently by two clinical experts for a total of four analysis runs; once with ABE and once again with the manual exclusion of ineligible beats. The inter-rater variability and reproducibility of the analysis with and without ABE were assessed by comparing the agreement of analysis runs with respect to secondary morphology detection, primary morphology ECG template and the percentage of both, as these aspects have been previously used to discriminate PAF patients from controls. Results Comparing ABE to manual exclusion in detecting secondary P-wave morphologies displayed substantial (Cohen"s k = 0.69) to almost perfect (k = 0.82) agreement. Area difference among auto and manually calculated main morphology templates was in every case <5% (p < 0.01) and the correlation coefficient was >0.99 (p < 0.01). Finally, the percentages of beats classified to the primary or secondary morphology per recording by each analysis were strongly correlated, for both main and secondary P-wave morphologies, ranging from ρ=0.756 to ρ=0.940 (picture) Conclusion The use of the ABE algorithm does not diminish inter-rater variability and reproducibility of the analysis. The primary and secondary P-wave morphologies produced by all analyses were similar, both in terms of their template and their frequency. Based on the results of this study, the ABE algorithm incorporated in the beat-to-beat P-wave morphology analysis drastically reduces operator workload without influencing the quality of the analysis. Abstract Figure.

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