Controlled Release of Growth Factor Using Poly(N-Isopropyl Acrylamide)Copolymer Hydrogels with Different Volume Phase Transition Temperatures

2005 ◽  
Vol 277-279 ◽  
pp. 77-81
Author(s):  
Young A Han ◽  
Jeong Ok Lim ◽  
Jin Hyun Choi ◽  
Byung Chul Ji
Keyword(s):  
Phase Transition ◽  
Transition Temperature ◽  
Phase Transition Temperature ◽  
Crosslinking Agent ◽  
Volume Phase Transition ◽  
Release Behavior ◽  
Volume Phase ◽  
Volume Phase Transition Temperature ◽  
Isopropyl Acrylamide ◽  
Phase Transition Temperatures

The release behavior of the basic fibroblast growth factor (bFGF) from copolymer hydrogels of N-isopropyl acrylamide (NIPAAm) and sodium methacrylate (SMA) was investigated in relation to the volume phase transition temperatures, which was increased by the incorporation of SMA. In the case of the copolymer hydrogels, a higher volume phase transition temperature was obtained when poly(ethylene glycol) diacrylate (PEGDA) was used as the crosslinking agent, suggesting that the chain length of the crosslinking agent has a significant affect on the volume phase transition temperature of a P(NIPAAm-co-SMA) hydrogel. The concentration of bFGF released from the hydrogels with PEGDA increased relative to the water content, thereby showing a dependence on the volume phase transition temperature. Hence, the release behavior of bFGF from the PNIPAAm and P(NIPAAm-co-SMA) hydrogels was found to be affected by the volume phase transition temperature, which can be easily controlled by changing the comonomer, monomer feed ratio, and crosslinking agent.

scholarly journals A robust method to calculate the volume phase transition temperature (VPTT) for hydrogels and hybrids

RSC Advances ◽  
2017 ◽  
Vol 7 (84) ◽  
pp. 53192-53202 ◽  
Author(s):  
Sulalit Bandyopadhyay ◽  
Anuvansh Sharma ◽  
Muhammad Awais Ashfaq Alvi ◽  
Rajesh Raju ◽  
Wilhelm Robert Glomm
Keyword(s):  
Phase Transition ◽  
Transition Temperature ◽  
Phase Transition Temperature ◽  
Volume Phase Transition ◽  
Transition Temperatures ◽  
Robust Method ◽  
Volume Phase ◽  
Volume Phase Transition Temperature ◽  
Phase Transition Temperatures

Phase transition temperatures along with system reversibilities defined by a unique reversibility parameter have been developed in this study.

A redox-labile poly(oligo(ethylene glycol)methacrylate)-based nanogel with tunable thermosensitivity for drug delivery

2016 ◽  
Vol 7 (10) ◽  
pp. 1913-1921 ◽  
Author(s):  
Yefei Tian ◽  
Shanshan Bian ◽  
Wuli Yang
Keyword(s):  
Phase Transition ◽  
Drug Delivery ◽  
Transition Temperature ◽  
Ethylene Glycol ◽  
Phase Transition Temperature ◽  
Precipitation Polymerization ◽  
Volume Phase Transition ◽  
Glycol Methacrylate ◽  
Volume Phase ◽  
Volume Phase Transition Temperature

We developed a redox degradable P(MEO2MA-s-s-OEGMA) nanogel with tunable volume phase transition temperature for drug delivery via precipitation polymerization using a disulfide-containing crosslinker.

scholarly journals Thermoresponsive Behavior of Magnetic Nanoparticle Complexed pNIPAm-co-AAc Microgels

2018 ◽  
Vol 8 (10) ◽  
pp. 1984 ◽  
Author(s):  
Su-Kyoung Lee ◽  
Yongdoo Park ◽  
Jongseong Kim
Keyword(s):  
Phase Transition ◽  
Transition Temperature ◽  
Magnetic Nanoparticles ◽  
Phase Transition Temperature ◽  
Functional Materials ◽  
Inorganic Nanoparticles ◽  
Temperature Hysteresis ◽  
Volume Phase Transition ◽  
Volume Phase ◽  
Volume Phase Transition Temperature

Characterization of responsive hydrogels and their enhancement with novel moieties have improved our understanding of functional materials. Hydrogels coupled with inorganic nanoparticles have been sought for novel types of responsive materials, but the efficient routes for the formation and the responsivity of complexed materials remain for further investigation. Here, we report that responsive poly(N-isopropylacrylamide-co-acrylic acid) (pNIPAm-co-AAc) hydrogel microparticles (microgels) are tunable by varying composition of co-monomer and crosslinker as well as by their complexation with magnetic nanoparticles in aqueous dispersions. Our results show that the hydrodynamic diameter and thermoresponsivity of microgels are closely related with the composition of anionic co-monomer, AAc and crosslinker, N,N′-Methylenebisacrylamide (BIS). As a composition of hydrogels, the higher AAc increases the swelling size of the microgels and the volume phase transition temperature (VPTT), but the higher BIS decreases the size with no apparent effect on the VPTT. When the anionic microgels are complexed with amine-modified magnetic nanoparticles (aMNP) via electrostatic interaction, the microgels decrease in diameter at 25 °C and shift the volume phase transition temperature (VPTT) to a higher temperature. Hysteresis on the thermoresponsive behavior of microgels is also measured to validate the utility of aMNP-microgel complexation. These results suggest a simple, yet valuable route for development of advanced responsive microgels, which hints at the formation of soft nanomaterials enhanced by inorganic nanoparticles.

Changes in the volume phase transition temperature of hydrogels for detection of the DNA hybridization process

The Analyst ◽  
2016 ◽  
Vol 141 (20) ◽  
pp. 5815-5821 ◽  
Author(s):  
Klaudia Kaniewska ◽  
Agata Kowalczyk ◽  
Marcin Karbarz ◽  
Anna M. Nowicka
Keyword(s):  
Phase Transition ◽  
Transition Temperature ◽  
Phase Transition Temperature ◽  
Dna Hybridization ◽  
Volume Phase Transition ◽  
Volume Phase ◽  
Volume Phase Transition Temperature ◽  
Target Dna ◽  
Thermoresponsive Hydrogels

A simple biosensing platform which involves the application of thermoresponsive hydrogels for the biochemical recognition of target DNA is presented.

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