Electrospun Poly(L-lacticacid)/Nano-Hydroxyapatite Hybrid Nanofibers and Their Potential in Dental Tissue Engineering

2007 ◽  
Vol 330-332 ◽  
pp. 377-380 ◽  
Author(s):  
M. M. Xu ◽  
Fang Mei ◽  
Dan Li ◽  
Xiao Ping Yang ◽  
Gang Sui ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Lactic Acid ◽  
Optimal Condition ◽  
Electrospinning Process ◽  
Dental Tissue ◽  
Normal Cells ◽  
Hybrid Nanofibers ◽  
Nanofibrous Scaffolds ◽  
Cell Carrier ◽  
Dental Tissue Engineering

Efficacy of poly(L-lactic acid) (PLLA)/nano-hydroxyapatite(HA) hybrid nanofibrous scaffolds for dental tissue engineering is described and their performance on normal cells with MG-63 is compared as well in this study. Perfectly PLLA/HA fibrous scaffolds were fabricated by an electrospinning process under optimal condition. Cell culcure and adenovirus encoding green fluorenscent protein technique were used to study the morphology of cells grown on the scaffolds. The results show that the growth of DPSCs and PCs is well observed attached to the PLLA/HA fibers, as well as MG-63, which indicate that the nanofibrous PLLA/HA scaffold could be used as a potential cell carrier in dental tissue engineering.

Electrospun PLLA/MWNTs/HA Hybrid Nanofiber Scaffolds and Their Potential in Dental Tissue Engineering

2007 ◽  
Vol 330-332 ◽  
pp. 393-396 ◽  
Author(s):  
Xu Liang Deng ◽  
M. M. Xu ◽  
Dan Li ◽  
Gang Sui ◽  
X. Y. Hu ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Average Diameter ◽  
Nano Particles ◽  
Potential Candidate ◽  
High Porosity ◽  
Hybrid Fibers ◽  
Dental Tissue ◽  
Nanofibrous Scaffolds ◽  
Hybrid Nanofiber ◽  
Dental Tissue Engineering

Novel Poly(l-lactic acid) (PLLA)/ Multi-walled carbon nanotubes (MWNTs)/ hydroxyapatite (HA) nanofibrous scaffolds with high porosity and well-controlled pore architectures were prepared via electrospinning techniques. The structure, morphology, molecular weight change of the scaffolds were investigated using scanning electron microscopy (SEM). The results noticed that the average diameter of hybrid nanofiber was similar to that of PLLA/HA fiber, but the surface of hybrid fibers was much coarser because of the introduction of MWNTs nano-particles. The biocompatibility of the scaffold has been investigated by human Dental Pulp Stem Cells (DPSCs) cell culture on the scaffold. The preliminary results showed that cells were well adhered and proliferated on the hybrid scaffolds as well as PLLA/HA fibers. Based on the experimental observations, the aligned nanofibrous PLLA/ MWNTs /HA scaffold could be used as a potential candidate scaffold in dental tissue engineering.

Design and fabrication of M-SAPO-34/chitosan scaffolds and evaluation of their effects on dental tissue engineering

2021 ◽  
Author(s):  
Golnaz Navidi ◽  
Maryam Allahvirdinesbat ◽  
Seyed Mohammad Mousavi Al-Molki ◽  
Soodabeh Davaran ◽  
Parvaneh Nakhostin Panahi ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Dental Tissue ◽  
Chitosan Scaffolds ◽  
Dental Tissue Engineering

scholarly journals Design and Biophysical Characterization of Poly (l-Lactic) Acid Microcarriers with and without Modification of Chitosan and Nanohydroxyapatite

Polymers ◽  
2018 ◽  
Vol 10 (10) ◽  
pp. 1061 ◽  
Author(s):  
Liying Li ◽  
Kedong Song ◽  
Yongzhi Chen ◽  
Yiwei Wang ◽  
Fangxin Shi ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Cell Culture ◽  
Lactic Acid ◽  
Average Diameter ◽  
Natural Polymers ◽  
Promoting Effect ◽  
Biophysical Characterization ◽  
Promising Tool ◽  
Cell Carrier

Nowadays, microcarriers are widely utilized in drug delivery, defect filling, and cell culture. Also, many researchers focus on the combination of synthetic and natural polymers and bioactive ceramics to prepare composite biomaterials for tissue engineering and regeneration. In this study, three kinds of microcarriers were prepared based on physical doping and surface modification, named Poly (l-lactic) acid (PLLA), PLLA/nanohydroxyapatite (PLLA/nHA), and PLLA/nHA/Chitosan (PLLA/nHA/Ch). The physicochemical properties of the microcarriers and their functional performances in MC3T3-E1 cell culture were compared. Statistical results showed that the average diameter of PLLA microcarriers was 291.9 ± 30.7 μm, and that of PLLA/nHA and PLLA/nHA/Ch microcarriers decreased to 275.7 ± 30.6 μm and 269.4 ± 26.3 μm, respectively. The surface roughness and protein adsorption of microcarriers were enhanced with the doping of nHA and coating of chitosan. The cell-carrier cultivation stated that the PLLA/nHA microcarriers had the greatest proliferation-promoting effect, while the PLLA/nHA/Ch microcarriers performed the strongest attachment with MC3T3-E1 cells. Besides, the cells on the PLLA/nHA/Ch microcarriers exhibited optimal osteogenic expression. Generally, chitosan was found to improve microcarriers with superior characteristics in cell adhesion and differentiation, and nanohydroxyapatite was beneficial for microcarriers regarding sphericity and cell proliferation. Overall, the modified microcarriers may be considered as a promising tool for bone tissue engineering.

scholarly journals Biodegradable polymers for dental tissue engineering and regeneration

2017 ◽  
pp. 237-296
Author(s):  
Raffaele Conte ◽  
Francesco Riccitiello ◽  
Adriana De Luise ◽  
Orsolina Petillo ◽  
Carlo Rengo ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Biodegradable Polymers ◽  
Dental Tissue ◽  
Dental Tissue Engineering

3D Functional scaffolds for dental tissue engineering

2018 ◽  
pp. 423-450 ◽  
Author(s):  
Cristiana R. Silva ◽  
Manuel Gomez-Florit ◽  
Pedro S. Babo ◽  
Rui L. Reis ◽  
Manuela E. Gomes
Keyword(s):  
Tissue Engineering ◽  
Dental Tissue ◽  
Dental Tissue Engineering

Dental Tissue Engineering Research and Translational Approaches towards Clinical Application

2013 ◽  
pp. 279-312
Author(s):  
Athina Bakopoulou ◽  
Gabriele Leyhausen ◽  
Werner Geurtsen ◽  
Petros Koidis
Keyword(s):  
Tissue Engineering ◽  
Stem Cell ◽  
Clinical Application ◽  
Exciting Field ◽  
Dental Tissue ◽  
Engineering Research ◽  
Biomimetic Scaffold ◽  
Research Findings ◽  
Dental Tissue Engineering ◽  
State Of The Science

Stem cell-based dental tissue regeneration is a new and exciting field that has the potential to transform the way that we practice dentistry. It is, however, imperative its clinical application is supported by solid basic and translational research. In this way, the full extent of the potential risks involved in the use of these technologies will be understood, and the means to prevent them will be discovered. Therefore, the aim of this chapter is to analyze the state-of-the-science with regard to dental pulp stem cell research in dental tissue engineering, the new developments in biomimetic scaffold materials customized for dental tissue applications, and to give a prospectus with respect to translational approaches of these research findings towards clinical application.

scholarly journals Multi-photon polymerization of bio-inspired, thymol-functionalized hybrid materials with biocompatible and antimicrobial activity

2020 ◽  
Vol 11 (25) ◽  
pp. 4078-4083
Author(s):  
Kostas Parkatzidis ◽  
Maria Chatzinikolaidou ◽  
Eleftherios Koufakis ◽  
Maria Kaliva ◽  
Maria Farsari ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Antimicrobial Activity ◽  
Hybrid Materials ◽  
Antimicrobial Action ◽  
Dental Tissue ◽  
3D Scaffolds ◽  
Dental Tissue Engineering

Thymyl-methacrylate functionalized, hybrid 3D scaffolds, fabricated by multi-photon lithography, exhibit excellent biocompatibility and antimicrobial action for bone and dental tissue engineering.

Sign in / Sign up

Export Citation Format

Share Document