Microstructure and Properties of A Calcium Phosphate Cement Tissue Engineering Scaffold Modified with Collagen and Chitosan

2007 ◽  
Vol 330-332 ◽  
pp. 983-986
Author(s):  
Xiu Peng Wang ◽  
Jian Dong Ye ◽  
Ling Chen ◽  
Ying Jun Wang
Keyword(s):  
Tissue Engineering ◽  
Cell Culture ◽  
Compressive Strength ◽  
Calcium Phosphate ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Calcium Phosphate Cement ◽  
Tissue Engineering Scaffold ◽  
Promising Material ◽  
Microstructure And Properties

In this study, an ACP-DCPD based Calcium phosphate cement (CPC) scaffold with a porosity of 88% was prepared by using Na3PO4 as a poregen and then modified by collagen and chitosan. The results showed that collagen and chitosan obviously increased the compressive strength. Cell culture showed that the cell can migrate, attach, proliferate and differentiate on the surface of the materials and the pores walls. This CPC scaffold modified with collagen or chitosan was a promising material to be used in bone tissue engineering.

Preparation and characterization of calcium phosphate/pectin scaffolds for bone tissue engineering

RSC Advances ◽  
2016 ◽  
Vol 6 (67) ◽  
pp. 62071-62082 ◽  
Author(s):  
Lisheng Zhao ◽  
Junjie Li ◽  
Liang Zhang ◽  
Yu Wang ◽  
Jiexin Wang ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Compressive Strength ◽  
Calcium Phosphate ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Clinical Application ◽  
Calcium Phosphate Cement ◽  
Bone Defects

A calcium phosphate cement (CPC) scaffold has been used to repair bone defects, but its low compressive strength and poor osteogenesis greatly hinder its clinical application.

Preparation and characterization of nano biphasic calcium phosphate/poly-L-lactide composite scaffold

2016 ◽  
Vol 23 (1) ◽  
pp. 37-44 ◽  
Author(s):  
Weizhong Yang ◽  
Yong Yi ◽  
Yuan Ma ◽  
Li Zhang ◽  
Jianwen Gu ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Calcium Phosphate ◽  
Cell Viability ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Biphasic Calcium Phosphate ◽  
Composite Scaffold ◽  
Pore Wall ◽  
Tissue Engineering Scaffold ◽  
Plla Scaffold

AbstractNano biphasic calcium phosphate (BCP) particles were synthesized using the sol-gel method. As-prepared BCP particles were combined with poly-L-lactide (PLLA) to fabricate nano-BCP/PLLA composite scaffold through a series of processing steps containing solvent self-diffusion, hot-pressing, and particulate leaching. The composite had a suitable porous structure for bone tissue engineering scaffold. In comparison, micro-BCP/PLLA scaffold was studied as well. Nano-BCP particles were distributed homogeneously in the PLLA matrix, and much more tiny crystallites exposed on the surface of the pore wall. Due to the finer inorganic particle distribution in the PLLA phase and the larger area of the bioactive phase exposed in the pore wall surface, nano-BCP/PLLA scaffold had enhanced compressive strength, good bioactivity, and superior cell viability. A nonstoichiometric apatite layer could be rapidly formed on the surface of nano- BCP/PLLA when soaked in simulated body fluid. The MG-63 cell viability of nano-BCP/PLLA scaffold is significantly higher than that of micro-BCP/PLLA scaffold. Therefore, nano-BCP/PLLA composite may be a suitable alternative for bone tissue engineering scaffold.

scholarly journals Incorporation of fast dissolving glucose porogens into an injectable calcium phosphate cement for bone tissue engineering

2017 ◽  
Vol 50 ◽  
pp. 68-77 ◽  
Author(s):  
Brandon T. Smith ◽  
Marco Santoro ◽  
Eline C. Grosfeld ◽  
Sarita R. Shah ◽  
Jeroen J.J.P. van den Beucken ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Calcium Phosphate ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Calcium Phosphate Cement

Preparation and Properties on Silk Fibers Reinforced Hydroxyapatite/Chitosan Composites

2010 ◽  
Vol 105-106 ◽  
pp. 557-560 ◽  
Author(s):  
Jing Wang ◽  
Q.Z. Sun ◽  
Jing Gao ◽  
D.M. Liu ◽  
Xiang Cai Meng ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Cell Culture ◽  
Compressive Strength ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Biological Properties ◽  
X Rays ◽  
Silk Fibers ◽  
Initial Strength ◽  
Scaffold Materials

Silk fibers were introduced into hydroxyapatite(HA)/chitosan(CS) matrix to prepare scaffold materials of bone tissue engineering with the adequate initial strength and improved cellular affinity using combination of in situ synthesis and freeze-drying technique. Chemical component was investigated using X rays diffraction (XRD) and Fourier transform infrared spectrum (FTIR). Structure and morphology of the composites were observed by scanning electron microscope (SEM). Porosity was tested by liquid substitution method. The mechanical properties of the composites were also measured. The simulated body fluid (SBF) and the cell culture experiments were conducted to assess biological properties of the composites. Results show that the composites with a pore size of 100~250μm have a porosity of 75%~90%and the maximum compressive strength of 5.7 MPa. The compressive strength of the composite is greatly improved in comparison with that of HA/CS matrix (4.6 MPa). In the SBF tests, a layer of randomly oriented apatite crystals form on the scaffold surface after sample immersion in SBF. The cell culture experiments show that the osteoblast cells are attached and proliferated on the surface of the composite, which suggests good bioactivity and cellular compatibility of the composite material. It is concluded that the composites have a promising prospect as bone tissue engineering materials.

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