A Novel Degradation Controlled Hyaluronic Acid Derivatives
2007 ◽
Vol 342-343
◽
pp. 525-528
Keyword(s):
A novel protocol to control the molecular degradation of hyaluronic acid (HA) was successfully developed. HA has a different conformational structure in water and in organic solvent, and the carboxyl group of HA is known to be the recognition site of CD44 and hyaluronidase. Based on these facts, HA was chemically modified in the mixed solvent of water and ethanol by grafting adipic acid dihydrazide (ADH) to the carboxyl group of HA, which resulted in high degree of ADH modification up to 85 mol% with controlled degradation of HA by hyaluronidase. The degradation controlled HA-ADH will be assessed for various tissue engineering applications.
2000 ◽
Vol 50
(4)
◽
pp. 574-584
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2006 ◽
Vol 6
(10)
◽
pp. 811-817
◽
Keyword(s):
2014 ◽
Vol 37
◽
pp. 405
◽
2018 ◽
Vol 170
◽
pp. 152-162
◽
2020 ◽
Vol 144
◽
pp. 837-846
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Keyword(s):