The association between threatened miscarriage and development of gestational hypertension/pre-eclampsia

Introduction: Gestational hypertension (GH)/Pre-eclampsia (PEC) is an important cause of direct maternal deaths in Sri Lanka. GH/PEC and threatened miscarriage (TM) share common pathophysiological mechanisms. This study was conducted to determine the association between TM and development of GH/PEC. Methodology: A case control study was conducted at Castle Street Hospital for Women, Sri Lanka from April 2015 to October 2015. Cases consisted of patients with GH/PEC and compared with age and parity matched controls. A systematic random sampling method was used. Similar number of cases and controls were compared while each group consisted of 245 subjects. Data was obtained from medical records. It is also important to note that mothers aged 20-35 years were included and medical disorders other than GH/PEC was excluded. Results: There were 245 subjects in each group of the study. Among the cases, 56% had GH and the rest had PEC. There were 25 patients with TM in the study population and 64% of them subsequently developed GH or PEC. There is also a significant risk of developing PEC in a patient who had a history of threatened miscarriage (OR 3.31, 95% CI 1.35-8.11). Moreover the patients who had a history of TM tend to develop GH or PEC early, within 20-32 weeks of gestation (OR 11.49, 95% CI 3.88-33.99). As we identified, 62% of patients who had TM developed GH/PEC early (from 20 to 32 weeks) but among the cases who had no history of TM, only 12% developed GH/PEC between 20 to 32 weeks of gestation (O.R. 20.7 (5.66 to 91.96). There is a significant risk of developing severe GH/PEC in the group of patients who had a history of TM (OR 8.59, 95% CI 2.87- 25.66). Eighty one percent (81%) of the cases, who had a history of TM, developed severe and moderate GH/PEC rather than mild. But the majority (63%) of the cases, who had no history of TM, developed mild GH/PEC (O.R. 7.6 (2.00 to 42.55).

Download Full-text

Impact act of treatment oft he gestational hypertension with methyldopa or nifedipin retard on dopplersonographic parameters

Geburtshilfe und Frauenheilkunde ◽

10.1055/s-0037-1600064 ◽

2017 ◽

Vol 77 (04) ◽

pp. 379-395

Author(s):

D Habek ◽

T Kulaš ◽

J Čerkez Habek

Keyword(s):

Gestational Hypertension

Download Full-text

Waist circumference,BMI,Lipid profile between 6-16 weeks of pregnancy as predictors of Gestational hypertension & Pre-eclampsia

Indian Journal Of Applied Research ◽

10.15373/2249555x/feb2013/93 ◽

2011 ◽

Vol 3 (2) ◽

pp. 274-276 ◽

Cited By ~ 1

Author(s):

Dr. Hina Kausar ◽

◽

Dr. Suchita Dabhadkar ◽

Dr. Savita Mehendale ◽

Dr. Yashwant S Kulkarni

Keyword(s):

Waist Circumference ◽

Lipid Profile ◽

Gestational Hypertension

Download Full-text

Vascularisation of the placental villi at gestational hypertension and preeclampsia

10.26226/morressier.5b4709866f4cb30010951ffa ◽

2018 ◽

Author(s):

Alexander Shchegolev ◽

Uliana Tumanova

Keyword(s):

Gestational Hypertension ◽

Placental Villi

Download Full-text

Demographic Factors Associated with Congenital Malformations Among Young Infants in Fallujah Maternity and Children Hospital, Fallujah City, Iraq

10.31487/j.gg.2020.01.03 ◽

2020 ◽

pp. 1-5

Author(s):

Samira T.Abdulghani ◽

Samira T.Abdulghani

Keyword(s):

Developing Countries ◽

Congenital Anomalies ◽

Prevalence Rate ◽

Gestational Hypertension ◽

Heart Defects ◽

Demographic Factors ◽

Cross Sectional ◽

Factors Associated ◽

Young Infants ◽

History Of

Background: Congenital anomalies are a major cause of infant morbidity and mortality in developing countries including our country. Registries and data on these anomalies are still primitive and poorly collated. In this study we aimed to assess the important demographic factors associated with the development of congenital anomalies. Methods: This was a cross-sectional hospital-based study involving 880 infants in the 1st year of life registered in the birth defect unit in Fallujah Maternity and Children Hospital in the period between 1st of January 2017 to the 31st of December 2019. The prevalence rate, the pattern of anomalies and the factors associated with their occurrence were determined. Results: The prevalence rate of the group enrolled in this study was 31/1000 total births, congenital heart defects was the commonest followed by central nervous system anomalies, 58% of the infants were males, 65% had ≥ 2.5 kg birth weight & 95% were singletons. Family history of congenital anomalies was found in 31.25% of cases. The largest group of mothers (55.7%) were 21-30 years old & 92.5% of fathers were less than 45 years old. Parental consanguinity reported in 64.3% of the total cases. Only 4.5% of mothers reported history of fever during pregnancy, and none of them had history of exposure to x-ray or teratogenic drug use. Gestational hypertension was reported in 10% of the total (880) mothers, hypertension and diabetes mellitus in 0.3%, while hepatitis C, hepatitis B, toxoplasmosis and epilepsy, each was reported in only one mother (0.1% of the total). Regarding the outcome of pregnancy, 66.6% were live births, 24.2% were abortions and 9.2% were stillbirths. History of previous abortions was reported in 22% of cases. Urban residents accounted for 63% of the families of congenitally abnormal infants while 37% were rural. Conclusion: Congenital anomalies are still a major cause for concern and tension in Fallujah society, there is serious need to establish a surveillance and good statistical system for congenital anomalies and efforts should be made to raise awareness of their occurrence and the associated risk factors in Iraq and other developing countries.

Download Full-text

Meditation as Complementary Treatment for Chronic Gestational Hypertension

Case Medical Research ◽

10.31525/ct1-nct03873194 ◽

2019 ◽

Author(s):

Keyword(s):

Gestational Hypertension ◽

Complementary Treatment

Download Full-text

DESIGN AN “IN HOUSE” SOFTWARE FOR SCREENING PREECLAMPSIA BY MATERNAL FACTORS AND MEAN ARTERIAL PRESSURE AT 11 – 13 WEEKS IN COMMUNE HEALTH CENTERS.

Journal of Medicine and Pharmacy ◽

10.34071/jmp.2015.3.16 ◽

2015 ◽

pp. 115-126

Author(s):

Viet Nhan Nguyen ◽

Ngoc Thanh Cao ◽

Thi Minh Thi Ha ◽

Van Duc Vo ◽

Quang Vinh Truong ◽

...

Keyword(s):

Mean Arterial Pressure ◽

Arterial Pressure ◽

Gestational Hypertension ◽

Area Under The Curve ◽

Health Centers ◽

Maternal Factors ◽

Good Tool ◽

Uterine Artery Doppler ◽

Study Results ◽

In Pregnancy

Objective: Design an “in house” software for screening preeclampsia by maternal factors and mean arterial pressure at 11 – 13 gestational weeks in commune health centers. Methods: Based on the algorithms for calculating the risk of preeclampsia (PE) by maternal factors and mean artirial pressure at 11 - 13 gestational weeks in the study results of the authors, an “in house” software was deigned in Excel. The results of prediction preeclampsia by The Fetal Medicine Foundation (FMF)(version 2.3) were compared with the results by “in house” software in 1110 singleton pregnant women. Results: The “in house” software met the requirements for calculating the risks of PE and save data. FMF risk for gestational hypertension disorder in pregnancy by maternal factors, mean arterial pressure,uterine artery Doppler and PAPP-A has an area under the curve of 0.68 (95%CI: 0.59 – 0.78). The “in house” software risk for gestational hypertension in pregnancy by maternal factors, mean arterial pressure has an area under the curve of 0.643 (0.55 – 0.73) There was no statistically significant different between two programs (p:0.52). The risk cut-off 1:50 in the prediction of gestational hypertension of the “in house” software was used to identify the group of high risk with detetion rate (DR) 28.6% (95%CI: 14.9-42.2) comparing to 40.5% (95%CI:25.6-55.3) of FMF. Conclusion: The FMF version 2.3 is better but in the absence of Doppler ultrasound and PAPP-A test in the commune health cares, the “in house” software for screening PE is a good tool for councelling, following up and early intervention for PE.

Download Full-text