NF-kappaB Dependent IL-8 Secretion from Lung Epithelial Cells Induced by Peripheral Blood Monocytes Phagocytosing Mycobacterium Tuberculosis

2001 ◽  
Vol 51 (4) ◽  
pp. 315
Author(s):  
Jae Seuk Park ◽  
Young Koo Jee ◽  
Eun Kyoun Choi ◽  
Keun Youl Kim ◽  
Kye Young Lee
Keyword(s):  
Mycobacterium Tuberculosis ◽  
Epithelial Cells ◽  
Peripheral Blood ◽  
Lung Epithelial Cells ◽  
Blood Monocytes ◽  
Peripheral Blood Monocytes ◽  
Lung Epithelial ◽  
Nf Kappab

Phagocytosis of Drug-Resistant Mycobacterium Tuberculosis by Peripheral Blood Monocytes

1997 ◽  
Vol 44 (3) ◽  
pp. 470
Author(s):  
Jae Seuk Park ◽  
Jae Yeal Kim ◽  
Chul Gyu Yoo ◽  
Young Whan Kim ◽  
Sung Koo Han ◽  
...  
Keyword(s):  
Mycobacterium Tuberculosis ◽  
Peripheral Blood ◽  
Drug Resistant ◽  
Blood Monocytes ◽  
Peripheral Blood Monocytes

Metformin promotes Mycobacterium tuberculosis killing and increases the production of human β-defensins in lung epithelial cells and macrophages

2020 ◽  
Vol 22 (3) ◽  
pp. 111-118 ◽  
Author(s):  
Adrian Rodriguez-Carlos ◽  
Claudia Valdez-Miramontes ◽  
Paulina Marin-Luevano ◽  
Irma González-Curiel ◽  
Jose A. Enciso-Moreno ◽  
...  
Keyword(s):  
Mycobacterium Tuberculosis ◽  
Epithelial Cells ◽  
Lung Epithelial Cells ◽  
Lung Epithelial

scholarly journals Triptolide-induced Transrepression of IL-8 NF-kappaB in Lung Epithelial Cells

2001 ◽  
Vol 50 (1) ◽  
pp. 52
Author(s):  
Young Koo Jee ◽  
Yoon Seup Kim ◽  
Se Young Yun ◽  
Yong Ho Kim ◽  
Eun Kyoung Choi ◽  
...  
Keyword(s):  
Epithelial Cells ◽  
Lung Epithelial Cells ◽  
Lung Epithelial ◽  
Nf Kappab

scholarly journals Human Lung Epithelial Cells Contain Mycobacterium tuberculosis in a Late Endosomal Vacuole and Are Efficiently Recognized by CD8+ T Cells

PLoS ONE ◽  
2014 ◽  
Vol 9 (5) ◽  
pp. e97515 ◽  
Author(s):  
Melanie J. Harriff ◽  
Meghan E. Cansler ◽  
Katelynne Gardner Toren ◽  
Elizabeth T. Canfield ◽  
Stephen Kwak ◽  
...  
Keyword(s):  
T Cells ◽  
Mycobacterium Tuberculosis ◽  
Epithelial Cells ◽  
Cd8 T Cells ◽  
Human Lung ◽  
Lung Epithelial Cells ◽  
Lung Epithelial ◽  
Human Lung Epithelial Cells

Pro-inflammatory cytokine expression through NF-kappaB/IkappaB pathway in lung epithelial cells

2000 ◽  
Vol 49 (3) ◽  
pp. 332 ◽  
Author(s):  
Gye Young Park ◽  
Seung Hee Lee ◽  
Bin Hwangbo ◽  
Jae Joon Yim ◽  
Choon Taek Lee ◽  
...  
Keyword(s):  
Epithelial Cells ◽  
Inflammatory Cytokine ◽  
Cytokine Expression ◽  
Lung Epithelial Cells ◽  
Lung Epithelial ◽  
Nf Kappab

Steroid hormone modulates the production of cathelicidin and human β-defensins in lung epithelial cells and macrophages promoting Mycobacterium tuberculosis killing

Tuberculosis ◽  
2021 ◽  
pp. 102080
Author(s):  
Sara P. Marin-Luevano ◽  
Adrian Rodriguez-Carlos ◽  
Yolanda Jacobo-Delgado ◽  
Claudia Valdez-Miramontes ◽  
Jose A. Enciso-Moreno ◽  
...  
Keyword(s):  
Mycobacterium Tuberculosis ◽  
Epithelial Cells ◽  
Steroid Hormone ◽  
Lung Epithelial Cells ◽  
Lung Epithelial

scholarly journals Membrane Insertion of Mycobacterium tuberculosis EsxA in Cultured Lung Epithelial Cells

2020 ◽  
Author(s):  
Qi Zhang ◽  
Javier Aguilera ◽  
Salvador Vazquez Reyes ◽  
Jianjun Sun
Keyword(s):  
Mycobacterium Tuberculosis ◽  
Epithelial Cells ◽  
Cytolytic Activity ◽  
Current Data ◽  
Lung Epithelial Cells ◽  
Neutral Ph ◽  
Subcellular Compartments ◽  
Lung Epithelial ◽  
Important Virulence Factor ◽  
First Time

AbstractEsxA has long been recognized as an important virulence factor of Mycobacterium tuberculosis (Mtb) that plays an essential role in Mtb cytosolic translocation presumably by penetrating phagosomal membranes with its acidic pH-dependent membrane permeabilizing activity (MPA). However, current data suggest that the observed cytolytic activity of EsxA at neutral pH is due to contamination of ASB-14, a detergent used in EsxA protein purification, and the role of EsxA MPA in Mtb cytosolic translocation is also questionable. Here, we have obtained evidence that it is ASB-14, not EsxA that causes cytolysis at neutral pH. Quantitative liquid chromatography and mass spectrometry showed that even after gel filtration, dialysis, or passing through detergent removal column, the remaining ASB-14 in the EsxA protein solution was still at a concentration enough to kill cultured lung epithelial cells. When treated with trypsin or proteinase K, the digested EsxA protein solution with ASB-14 was still cytotoxic. Interestingly, however, we have found that the exogenously added EsxA is endocytosed into lung epithelial cells and inserts into the host membranes within acidic subcellular compartments, which can be blocked by cytochalasin D and bafilomycin A. It is for the first time EsxA is found to insert into the host membranes within acidic subcellular compartments.ImportanceEsxA has long been recognized as an important virulence factor of Mycobacterium tuberculosis (Mtb) that plays an essential role in Mtb virulence. However, current data regarding to its role in Mtb virulence are controversial. Here, we have obtained evidence showing that the cytolytic activity of EsxA at neutral pH is due to contamination of ASB-14, a detergent used in EsxA preparation. Moreover, it is for the first time we have found that EsxA protein is endocytosed into lung epithelial cells and inserts into the host membranes within acidic subcellular compartments, implicating an important role of the acidic pH-dependent membrane permeabilizing activity of EsxA in Mtb virulence.

Legionella pneumophila induced microRNA expression in human lung epithelial cells

Pneumologie ◽  
2010 ◽  
Vol 64 (S 03) ◽  
Author(s):  
B Schmeck ◽  
B Dolniak ◽  
I Pollock ◽  
C Schulz ◽  
W Bertrams ◽  
...  
Keyword(s):  
Epithelial Cells ◽  
Legionella Pneumophila ◽  
Human Lung ◽  
Microrna Expression ◽  
Lung Epithelial Cells ◽  
Lung Epithelial ◽  
Human Lung Epithelial Cells
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