Usefulness of the Pleural Fluid Adenosine Deaminase with Lymphocyte/Neutrophil Ratio in the Diagnosis of Tuberculous Pleurisy for a Region of Intermediate Prevalence of Tuberculosis

2009 ◽  
Vol 66 (6) ◽  
pp. 437 ◽  
Author(s):  
Chang Hwan Kim ◽  
Eun Kyung Mo ◽  
Sung Hoon Park ◽  
Yong Il Hwang ◽  
Seung Hun Jang ◽  
...  
Keyword(s):  
Adenosine Deaminase ◽  
Pleural Fluid ◽  
Tuberculous Pleurisy

Diagnostic value of pleural fluid adenosine deaminase activity in tuberculous pleurisy

2004 ◽  
Vol 341 (1-2) ◽  
pp. 101-107 ◽  
Author(s):  
Mo-Lung Chen ◽  
Wai-Cho Yu ◽  
Ching-Wan Lam ◽  
Kam-Ming Au ◽  
Fuk-Yip Kong ◽  
...  
Keyword(s):  
Adenosine Deaminase ◽  
Pleural Fluid ◽  
Diagnostic Value ◽  
Adenosine Deaminase Activity ◽  
Tuberculous Pleurisy

scholarly journals Diagnostic value of pleural fluid adenosine deaminase among the patients with pleural tuberculosis

2019 ◽  
Author(s):  
Fariborz Rousta ◽  
Mohsen Sokouti ◽  
Samad Beheshty Rouy ◽  
Sina Parsay
Keyword(s):  
Pleural Effusion ◽  
Adenosine Deaminase ◽  
Pleural Fluid ◽  
Predictive Value ◽  
Pathology Report ◽  
Tuberculous Lymphadenitis ◽  
Pleural Tuberculosis ◽  
Multiple Biopsies ◽  
Tuberculous Pleurisy ◽  
Exudative Pleural Effusion

Abstract Purpose Extra-pulmonary tuberculosis occurs in about 10-20% of patients most commonly as tuberculous lymphadenitis or pleural effusion. Pleural fluid Adenosine deaminase (ADA) activity considered as a useful biomarker for detecting pleural tuberculosis. The purpose of this study was to evaluate the diagnostic accuracy of pleural fluid adenosine deaminase level in patients with pleural tuberculosis. Methods In this cross-sectional study, 113 patients with exudative pleural effusion with unknown underlying diagnosis, were enrolled. Physical examination, chest CT, measurement of ADA level of pleural fluid, direct thoracoscopic examination, and biopsy of pleura were performed for all individuals. Results The diagnosis of tuberculous pleurisy was established in 40 individuals regarding the pathology report of biopsy samples. The mean ADA level of the TB and the non-TB group was 39.90±22.93 IU/L and 30.74±38.27 IU/L respectively, which was not statistically significant (P-value=0.167). Sensitivity, specificity, positive predictive value, and negative predictive value of ADA test were 35%, 86.30%, 58.33%, and 70.79%, respectively. Conclusion Based on low sensitivity and specificity of ADA test, in patients with unexplained exudative pleural effusion especially in those who were suspicious for tuberculous pleurisy, despite the low level of ADA, direct thoracoscopic pleural observation and multiple biopsies of pleura is highly recommended.

Diagnostic value of adenosine deaminase in tuberculous pleural effusion: a meta-analysis

2003 ◽  
Vol 40 (4) ◽  
pp. 374-381 ◽  
Author(s):  
Masashi Goto ◽  
Yoshinori Noguchi ◽  
Hiroshi Koyama ◽  
Kenji Hira ◽  
Takuro Shimbo ◽  
...  
Keyword(s):  
Pleural Effusion ◽  
Adenosine Deaminase ◽  
Pleural Fluid ◽  
Meta Analysis ◽  
Cochrane Library ◽  
Pleural Biopsy ◽  
Tuberculous Pleural Effusion ◽  
Test Characteristics ◽  
Tuberculous Pleurisy ◽  
Gold Standards

Background: Many studies have investigated the usefulness of adenosine deaminase activity (ADA) in pleural fluid for the early diagnosis of tuberculous pleurisy. To summarize the diagnostic characteristics of ADA we undertook a meta-analysis using a summary receiver operating characteristic (SROC) curve method. Methods: Data sources were MEDLINE (1966-1999), the Cochrane Library and bibliographies of review and original articles. Studies were included if the absolute numbers of true positive, false negative, true negative and false positive observations were available or could be derived from the data presented; gold standards were described explicitly; and the criteria for a positive ADA result were reported. We constructed an SROC curve based on these extracted data to estimate the test characteristics. Results: Forty articles were available for analysis. The gold standards used were pleural biopsy histology, microbiological examination of pleural fluid, pleural biopsy and sputum and the patient's clinical course or combinations of these. The sensitivity of ADA reported in the articles ranged from 47·1% to 100% and the specificity from 50·0% to 100%. The summary measure of test characteristics derived from the SROC curve was 92·2% for both sensitivity and specificity. Conclusions: The test performance of ADA in tuberculous pleural effusion is reasonably good. Measurement of pleural ADA is thus likely to be a useful diagnostic tool for tuberculous pleurisy.

scholarly journals Diagnostic value of combined pleural interleukin-33, adenosine deaminase and peripheral blood tuberculosis T cell spot detection TB for tuberculous pleurisy

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Jin Fenhua ◽  
Wang Daohui ◽  
Lin Hui ◽  
Xia Xiaodong ◽  
Huang Wen
Keyword(s):  
T Cell ◽  
Pleural Effusion ◽  
Adenosine Deaminase ◽  
Pleural Fluid ◽  
Peripheral Blood ◽  
Diagnostic Efficacy ◽  
Interleukin 33 ◽  
Spot Detection ◽  
Tuberculous Pleurisy ◽  
Combined Detection

Abstract Background To investigate the correlation between pleural fluid interleukin-33 (IL-33) and adenosine deaminase (ADA) and peripheral blood tuberculosis T cell spot detection (T-SPOT.TB), and the combined value of the three tests for the diagnosis of tuberculous pleurisy. Methods 79 patients with pleural effusion admitted from June 2017 to December 2018 were enrolled. They were divided into tuberculous pleural effusion (TPE) group (57 cases, 72.2%) and malignant pleural effusion group (17 cases, 21.5%), pneumonia-like pleural effusion group (5 cases, 6.3%). Correlation between pleural fluid IL-33, pleural effusion ADA and peripheral blood T-SPOT.TB was analyzed, comparison of the three separate and combined diagnostic efficacy was also performed. Results The levels of IL-33, ADA and peripheral blood T-SPOT.TB in patients with TPE were significantly higher than those in non-TPE (P < 0.001). The level of pleural fluid IL-33 was positively correlated with pleural effusion ADA and peripheral blood T-SPOT.TB. The Area under the ROC curve (AUC) of TPE diagnosed by pleural IL-33, ADA and peripheral blood T-SPOT.TB were 0.753, 0.912 and 0.865, respectively. AUC for combined detection of pleural effusion IL-33, ADA and peripheral blood T-SPOT.TB is the largest, with a value of 0.962. Specificity is 100% and sensitivity is 88.5%. Conclusion Combined detection of pleural effusion IL-33, ADA and peripheral blood T-SPOT.TB can improve the diagnostic efficacy of tuberculous pleurisy.

Diagnostic value of pleural fluid adenosine deaminase level in patient with tuberculous pleurisy

2016 ◽  
Author(s):  
Nino Mchedlishvili ◽  
Tinatin Mamaladze ◽  
Natalia Shubladze ◽  
Natia Gujabidze ◽  
Rusudan Marashanishvili
Keyword(s):  
Adenosine Deaminase ◽  
Pleural Fluid ◽  
Diagnostic Value ◽  
Tuberculous Pleurisy

Diagnostic Accuracy of Pleural Fluid Adenosine Deaminase for Diagnosing Tuberculosis. Meta-analysis of Spanish Studies

2019 ◽  
Vol 55 (1) ◽  
pp. 23-30 ◽  
Author(s):  
Rosa M. Palma ◽  
Silvia Bielsa ◽  
Aureli Esquerda ◽  
Montserrat Martínez-Alonso ◽  
José M. Porcel
Keyword(s):  
Diagnostic Accuracy ◽  
Adenosine Deaminase ◽  
Pleural Fluid ◽  
Meta Analysis

scholarly journals The relation of the pleural thickening in tuberculosis pleurisy with the activity of adenosine deaminase

2005 ◽  
Vol 63 (2) ◽  
Author(s):  
B. Uskul ◽  
H. Turker ◽  
C. Ulman ◽  
M. Ertugrul ◽  
A. Selvi ◽  
...  
Keyword(s):  
Pleural Effusion ◽  
Adenosine Deaminase ◽  
Pleural Fluid ◽  
Clinical Findings ◽  
X Rays ◽  
Biochemical Tests ◽  
Pleural Thickening ◽  
Group I ◽  
Immunological Mechanisms ◽  
Tuberculosis Pleurisy

Selvi, A. Kant, S. Arslan, M. Ozgel. Background: Residual pleural thickening (RPT) still occurs in most patients with tuberculosis pleurisy despite advances in the treatment of tuberculosis. The aim of this study was to evaluate the significance of RPT in tuberculosis pleurisy with the patients clinical findings, biochemical and microbiological properties of pleural effusion and with the total adenosine deaminase (ADA) and isoenzymes levels. Methods: 121 tuberculosis pleurisy patients were evaluated retrospectively. According to posteroanterior chest x-rays, the 63 (52%) cases with the thickness 2 mm or more in lower lateral hemithorax were grouped as I and the 58 (48%) cases without pleural thickness were grouped as II. The amount of pleural effusion was classified into small, medium or massive according to their chest x-rays. In both groups; sex, age, symptoms score, bacteriological and biochemical tests and ADA levels were recorded. Results: 81 (67%) male and 40 (33%) female, overall 121 patients were enrolled into the study. RPT was found higher in males (p=0.014) and the increase ran parallel with the amount of cigarette smoking (p=0.014). RPT was found to be lower in small effusions (p=0.001). The group with RPT, the serum albumin was found lower (p=0.002), pleural fluid total protein (p=0.047) and the ratio of pleural fluid protein to serum protein (p=0.002) were found higher. In group I, total ADA: 69.5±38.9 IU/L and ADA2: 41.3±31.6 IU/L were higher than the cases without RPT (p=0.032, p=0.017, respectively). Conclusions: We suggest that the immunological mechanisms are effective in the development of pleural thickening.

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