scholarly journals Autoimmune Vitiligo Does Not Require the Ongoing Priming of Naive CD8 T Cells for Disease Progression or Associated Protection against Melanoma

2014 ◽  
Vol 192 (4) ◽  
pp. 1433-1439 ◽  
Author(s):  
Katelyn T. Byrne ◽  
Peisheng Zhang ◽  
Shannon M. Steinberg ◽  
Mary Jo Turk
Keyword(s):  
T Cells ◽  
Disease Progression ◽  
Cd8 T Cells ◽  
Autoimmune Vitiligo

Disease Progression in Children with Perinatal HIV Correlates with Increased PD-1+ CD8 T Cells that Coexpress Multiple Immune Checkpoints

2021 ◽  
Author(s):  
Janki Tailor ◽  
Julia Foldi ◽  
Matthew Generoso ◽  
Bret McCarty ◽  
Aparna Alankar ◽  
...  
Keyword(s):  
T Cells ◽  
Disease Progression ◽  
Cd8 T Cells ◽  
Pediatric Hiv ◽  
Immune Checkpoints ◽  
Hiv Disease ◽  
Art Initiation ◽  
Perinatal Hiv ◽  
Living With Hiv

Abstract Background PD-1 marks exhausted T cells, with weak effector functions. Adults living with HIV have increased levels of PD-1+ CD8 T cells that correlate with HIV disease progression, yet little is known about the role of PD-1+ CD8 T cells in children with perinatal HIV. Methods We enrolled 76 Kenyan children with perinatal HIV and 43 children who were HIV unexposed and quantified PD-1 levels on CD8 T cells, their coexpression with immune checkpoints (IC) 2B4, CD160 and TIM3, correlates with immune activation and HIV disease progression and HIV-specific and non-specific proliferative responses. Results PD-1+ CD8 T cell frequencies are elevated in children with perinatal HIV and associated with disease progression. The majority of PD-1+ CD8 T cells coexpress additional ICs. ART initiation lowers total PD-1 levels and coexpression of multiple ICs. The frequency of PD-1 + 2B4+CD160+TIM3- in PD-1+ CD8 T cells, predicts weaker HIV-specific proliferative responses, suggesting this subset is functionally exhausted. Conclusion Children with perinatal HIV have high PD-1+ CD8 T cells that are a heterogeneous population differentially coexpressing multiple ICs. Understanding the complex interplay of ICs is essential to guide the development of PD-1 directed immunotherapies for pediatric HIV remission and cure.

Engagement of NK receptor NKG2D, but not 2B4, results in self-reactive CD8+T cells and autoimmune vitiligo

Autoimmunity ◽  
2011 ◽  
Vol 44 (8) ◽  
pp. 599-606 ◽  
Author(s):  
Andrew Zloza ◽  
Gretchen E. Lyons ◽  
Lukasz K. Chlewicki ◽  
Frederick J. Kohlhapp ◽  
Jeremy A. O'sullivan ◽  
...  
Keyword(s):  
T Cells ◽  
Cd8 T Cells ◽  
Autoimmune Vitiligo ◽  
Nk Receptor

CD38 expression on cryopreserved CD8+ T cells predicts HIV disease progression

Cytometry ◽  
1998 ◽  
Vol 33 (2) ◽  
pp. 133-137 ◽  
Author(s):  
Stephen P. Perfetto ◽  
John D. Malone ◽  
Clifton Hawkes ◽  
Gilbert McCrary ◽  
Bob August ◽  
...  
Keyword(s):  
T Cells ◽  
Disease Progression ◽  
Cd8 T Cells ◽  
Hiv Disease ◽  
Cd38 Expression

scholarly journals Inverted CD8 T-Cell Exhaustion and Co-Stimulation Marker Balance Differentiate Aviremic HIV-2-Infected From Seronegative Individuals

2021 ◽  
Vol 12 ◽  
Author(s):  
Lydia Scharf ◽  
Christina B. Pedersen ◽  
Emil Johansson ◽  
Jacob Lindman ◽  
Lars R. Olsen ◽  
...  
Keyword(s):  
T Cells ◽  
T Cell ◽  
Disease Progression ◽  
Cd8 T Cells ◽  
Therapy Monitoring ◽  
Expression Patterns ◽  
Cd8 T Cell ◽  
T Cell Exhaustion ◽  
Cell Exhaustion ◽  
Hiv 1

HIV-2 is less pathogenic compared to HIV-1. Still, disease progression may develop in aviremic HIV-2 infection, but the driving forces and mechanisms behind such development are unclear. Here, we aimed to reveal the immunophenotypic pattern associated with CD8 T-cell pathology in HIV-2 infection, in relation to viremia and markers of disease progression. The relationships between pathological differences of the CD8 T-cell memory population and viremia were analyzed in blood samples obtained from an occupational cohort in Guinea-Bissau, including HIV-2 viremic and aviremic individuals. For comparison, samples from HIV-1- or dually HIV-1/2-infected and seronegative individuals were obtained from the same cohort. CD8 T-cell exhaustion was evaluated by the combined expression patterns of activation, stimulatory and inhibitory immune checkpoint markers analyzed using multicolor flow cytometry and advanced bioinformatics. Unsupervised multidimensional clustering analysis identified a cluster of late differentiated CD8 T-cells expressing activation (CD38+, HLA-DRint/high), co-stimulatory (CD226+/-), and immune inhibitory (2B4+, PD-1high, TIGIThigh) markers that distinguished aviremic from viremic HIV-2, and treated from untreated HIV-1-infected individuals. This CD8 T-cell population displayed close correlations to CD4%, viremia, and plasma levels of IP-10, sCD14 and beta-2 microglobulin in HIV-2 infection. Detailed analysis revealed that aviremic HIV-2-infected individuals had higher frequencies of exhausted TIGIT+ CD8 T-cell populations lacking CD226, while reduced percentage of stimulation-receptive TIGIT-CD226+ CD8 T-cells, compared to seronegative individuals. Our results suggest that HIV-2 infection, independent of viremia, skews CD8 T-cells towards exhaustion and reduced co-stimulation readiness. Further knowledge on CD8 T-cell phenotypes might provide help in therapy monitoring and identification of immunotherapy targets.

scholarly journals Vaccine-Induced, Simian Immunodeficiency Virus-Specific CD8+T Cells Reduce Virus Replication but Do Not Protect from Simian Immunodeficiency Virus Disease Progression

2009 ◽  
Vol 183 (1) ◽  
pp. 706-717 ◽  
Author(s):  
Jessica C. Engram ◽  
Richard M. Dunham ◽  
George Makedonas ◽  
Thomas H. Vanderford ◽  
Beth Sumpter ◽  
...  
Keyword(s):  
T Cells ◽  
Disease Progression ◽  
Simian Immunodeficiency Virus ◽  
Virus Replication ◽  
Cd8 T Cells ◽  
Virus Disease ◽  
Immunodeficiency Virus ◽  
Reduce Virus Replication
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