scholarly journals Lipopolysaccharide-Elicited TSLPR Expression Enriches a Functionally Discrete Subset of Human CD14+CD1c+Monocytes

2017 ◽  
Vol 198 (9) ◽  
pp. 3426-3435 ◽  
Author(s):  
Francesco Borriello ◽  
Raffaella Iannone ◽  
Sarah Di Somma ◽  
Viviana Vastolo ◽  
Giuseppe Petrosino ◽  
...  
Keyword(s):  
Discrete Subset

scholarly journals The 72/74-kDa polypeptides of the 70–110S large heterogeneous nuclear ribonucleoprotein complex (LH-nRNP) represent a discrete subset of the hnRNP M protein family

2000 ◽  
Vol 350 (2) ◽  
pp. 495-503 ◽  
Author(s):  
Panayiota KAFASLA ◽  
Meropi PATRINOU-GEORGOULA ◽  
Apostolia GUIALIS
Keyword(s):  
Matrix Protein ◽  
Polyclonal Antibodies ◽  
Protein Family ◽  
M Protein ◽  
Major Protein ◽  
Discrete Subset ◽  
Two Dimensional Gel Electrophoresis ◽  
Nuclear Extracts ◽  
Protein Components ◽  
Nuclear Ribonucleoprotein

Pre-mRNA processing in eukaryotes is thought to take place on a multitude of nuclear ribonucleoprotein (RNP) complexes, the most abundant of them being the heterogeneous nuclear (hn) RNP complexes. The identification in mammalian nuclear extracts of a novel, less-abundant 70–110S heterogeneous RNP, named large heterogeneous nuclear RNP (LH-nRNP), has previously been reported by Aidinis, Sekeris and Guialis (1995) Nucleic Acids Res. 23, 2742–2753. The structural composition of the LH-nRNP complex has been determined following the production of polyclonal antibodies against the major protein constituents of the complex, the pair of the 72/74-kDa polypeptides. In the present study evidence is shown to prove that the 72/74-kDa proteins are members of the hnRNP M protein family, hereafter referred to as 72/74(M) polypeptides. The extensive application of two-dimensional gel electrophoresis, combined with specific immunoprecipitation and immunoblotting assays, has allowed the assignment of the 72/74(M) proteins to a subset of the hnRNP M family, characteristic of the presence of the LH-nRNP complex and distinct from the hnRNP-associated M1–M4 components. Moreover, the immunoselection of the LH-nRNP complex from [32P]orthophosphate-labelled HeLa cells, with the parallel application of UV irradiation, has permitted the identification of the 72/74(M) polypeptides as the sole protein constituents of the complex in direct contact with the RNA. It is proposed that LH-nRNP constitutes a discrete subset of hnRNP complexes, having a possible role in establishing specific interactions between hnRNP and nuclear-matrix protein components.

Uncountable Discrete Sets in Extensions and Metrizability

1982 ◽  
Vol 25 (4) ◽  
pp. 472-477 ◽  
Author(s):  
Murray Bell ◽  
John Ginsburg
Keyword(s):  
Topological Space ◽  
Compact Space ◽  
Continuum Hypothesis ◽  
Vietoris Topology ◽  
Discrete Subset ◽  
Similar Argument ◽  
Martin's Axiom ◽  
Martin’S Axiom ◽  
The Continuum

AbstractIf X is a topological space then exp X denotes the space of non-empty closed subsets of X with the Vietoris topology and λX denotes the superextension of X Using Martin's axiom together with the negation of the continuum hypothesis the following is proved: If every discrete subset of exp X is countable the X is compact and metrizable. As a corollary, if λX contains no uncountable discrete subsets then X is compact and metrizable. A similar argument establishes the metrizability of any compact space X whose square X × X contains no uncountable discrete subsets.

scholarly journals Fate-Mapping of GM-CSF Expression Identifies a Discrete Subset of Inflammation-Driving T Helper Cells Regulated by Cytokines IL-23 and IL-1β

Immunity ◽  
2019 ◽  
Vol 50 (5) ◽  
pp. 1289-1304.e6 ◽  
Author(s):  
Juliana Komuczki ◽  
Selma Tuzlak ◽  
Ekaterina Friebel ◽  
Tom Hartwig ◽  
Sabine Spath ◽  
...  
Keyword(s):  
T Helper Cells ◽  
Fate Mapping ◽  
Discrete Subset ◽  
T Helper ◽  
Gm Csf ◽  
Helper Cells

Topology for Computations of Concurrent Automata

1998 ◽  
Vol 08 (03) ◽  
pp. 327-362
Author(s):  
Dietrich Kuske ◽  
R. M. Shortt
Keyword(s):  
Topological Semigroup ◽  
Discrete Subset ◽  
Infinite Products ◽  
Discrete Subspace ◽  
Uniformly Continuous ◽  
Totally Disconnected

We generalize the results on α-complex traces from [14, 16] to the realm of concurrent automata. We show that the α-complex computations can be defined as elements of a compact, totally disconnected and complete topological semigroup containing the finite computations as a dense and discrete subspace. But in this semigroup it is not possible to define infinite products as limits of finite ones in a satisfactory way. Therefore, we define a second semigroup of restricted α-complex computations. The underlying set of this semigroup carries a metric such that it becomes compact and complete. Furthermore, the finite computations are a dense and discrete subset and the multiplication is uniformly continuous not on the whole semigroup but on the set of finite computations. Finally, here we can define infinite products as limits of finite ones.

MANY-VALUED R-S MEMORY CIRCUITS

2008 ◽  
Vol 16 (04) ◽  
pp. 495-518
Author(s):  
MILAN PETRÍK
Keyword(s):  
Discrete Subset ◽  
Memory Circuit ◽  
Input And Output ◽  
Memory Circuits ◽  
The Stability ◽  
The Many

In this paper we present a many-valued memory circuit based on a generalization of the R-S memory circuit known from the two-valued logical circuits. Based on this many-valued R-S memory circuit we introduce a many-valued level-controlled memory circuit and a many-valued edge-controlled memory circuit of type “master-slave”. We discuss problems of the stability of the circuit with respect to small errors of input and output signals as well as to small errors of the gates. We show that the stability can be preserved by restricting the set of logical values, i.e. the interval [0, 1], to a finite discrete subset of this interval. We find the set of many-valued operations which are suitable for the implementation of the many-valued R-S memory circuit.

scholarly journals Characterization of Circulating IL-7R Positive Cell Populations for Early Detection of Pancreatic Ductal Adenocarcinoma

2021 ◽  
Vol 10 (18) ◽  
pp. 4157
Author(s):  
Sun-Hee Heo ◽  
Sung Ill Jang ◽  
So Young Kim ◽  
Bongkun Choi ◽  
Dong Ki Lee ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Mouse Model ◽  
Cancer Patients ◽  
Tumor Formation ◽  
Ductal Adenocarcinoma ◽  
Effector Memory ◽  
Discrete Subset ◽  
Normal Individuals ◽  
Syngeneic Mouse Model

(1) Background: Pancreatic cancer is a high devastating disease with the lowest survival rate among all common cancers due to difficulties in early diagnosis. The purpose of this study was to identify and characterize the distinct subset of blood cell population elevated in peripheral blood mononuclear cells (PBMC) of pancreatic cancer to evaluate the potential markers for diagnosis of pancreatic cancer; (2) Methods: We analyzed differential gene expression in PBMC from normal individuals and pancreatic cancer patients utilizing transcriptome analysis. Flow cytometry analysis was applied to identify the discrete subset of interleukin-7 receptor (IL-7R) expressing cells in these cells. The expression of IL-7R during tumorigenesis was determined in syngeneic mouse model of pancreatic cancer in vivo; (3) Results: PBMC from pancreatic cancer patients expressed elevated IL-7R mRNA compared to healthy control individuals. IL-7R expressing cells rapidly appeared from the early stages of the onset of tumor formation in syngeneic pancreatic cancer mouse model in vivo. The discrete subset of IL-7R positive cells mainly consist of naive T, central memory T, and effector memory T cells; (4) Conclusions: Taken together, our present findings suggest that pancreatic cancer patients expressed higher level of IL-7R expression in PBMC that rapidly emerged from the onset of early pancreatic tumor formation in vivo than normal individuals. Thus, it can be used as a novel biological marker for early events of pancreatic cancer development.

scholarly journals What to Do When the Doctor Sees Double: Identical Twins with Nearly Identical Aneurysms

2001 ◽  
Vol 7 (2) ◽  
pp. 153-160 ◽  
Author(s):  
P.J. Porter ◽  
M. Tymianski ◽  
P.J. Muller ◽  
K.G. terBrugge
Keyword(s):  
Patient Management ◽  
Identical Twins ◽  
Discrete Subset ◽  
Anatomic Location ◽  
Familial Aneurysms

This report details the case of identical twins, both of whom had an aneurysm in the same anatomic location. Such aneurysms should be considered as a discrete subset of familial aneurysms. The implications for patient management are discussed.

Certain Subsets of Products of Metacompact Spaces and Subparacompact Spaces are Realcompact

1972 ◽  
Vol 24 (5) ◽  
pp. 825-829 ◽  
Author(s):  
Phillip Zenor
Keyword(s):  
Discrete Subset ◽  
Completely Regular

We will say that a space X has property (*) if and only if each discrete subset of X is realcompact; i.e., the cardinality of each discrete subset of X is nonmeasurable. In [8], Shirota shows that a completely regular T1-space X is realcompact if and only if X has property (*) and X is complete with respect to some uniformity. In [7], Moran, using measure theoretic techniques, shows that any normal metacompact T1-space with property (*) is realcompact.

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