scholarly journals Type 2 Cytotoxic T Lymphocytes Modulate the Activity of Dendritic Cells Toward Type 2 Immune Responses

2006 ◽  
Vol 177 (4) ◽  
pp. 2131-2137 ◽  
Author(s):  
Giandomenica Iezzi ◽  
Andrea Boni ◽  
Elena Degl’Innocenti ◽  
Matteo Grioni ◽  
Maria T. S. Bertilaccio ◽  
...  
Keyword(s):  
Dendritic Cells ◽  
T Lymphocytes ◽  
Immune Responses ◽  
Cytotoxic T Lymphocytes

scholarly journals Prolonged exposure of dendritic cells to maturation stimuli favors the induction of type-2 cytotoxic T lymphocytes

2006 ◽  
Vol 36 (12) ◽  
pp. 3157-3166 ◽  
Author(s):  
Andrea Boni ◽  
Giandomenica Iezzi ◽  
Elena Degl'Innocenti ◽  
Matteo Grioni ◽  
Elena Jachetti ◽  
...  
Keyword(s):  
Dendritic Cells ◽  
T Lymphocytes ◽  
Cytotoxic T Lymphocytes ◽  
Prolonged Exposure

scholarly journals Antigen-Specific Polyclonal Cytotoxic T Lymphocytes Induced by Fusions of Dendritic Cells and Tumor Cells

2010 ◽  
Vol 2010 ◽  
pp. 1-12 ◽  
Author(s):  
Shigeo Koido ◽  
Sadamu Homma ◽  
Eiichi Hara ◽  
Yoshihisa Namiki ◽  
Toshifumi Ohkusa ◽  
...  
Keyword(s):  
Dendritic Cells ◽  
T Lymphocytes ◽  
Immune Responses ◽  
Tumor Cells ◽  
Cytotoxic T Lymphocytes ◽  
Alternative Approach ◽  
Antigen Presenting ◽  
Ctl Induction ◽  
Secondary Lymphoid Organs ◽  
Powerful Strategy

The aim of cancer vaccines is induction of tumor-specific cytotoxic T lymphocytes (CTLs) that can reduce the tumor mass. Dendritic cells (DCs) are potent antigen-presenting cells and play a central role in the initiation and regulation of primary immune responses. Thus, DCs-based vaccination represents a potentially powerful strategy for induction of antigen-specific CTLs. Fusions of DCs and whole tumor cells represent an alternative approach to deliver, process, and subsequently present a broad spectrum of antigens, including those known and unidentified, in the context of costimulatory molecules. Once DCs/tumor fusions have been infused back into patient, they migrate to secondary lymphoid organs, where the generation of antigen-specific polyclonal CTL responses occurs. We will discuss perspectives for future development of DCs/tumor fusions for CTL induction.

scholarly journals Antigen-specific cytotoxic T lymphocytes target airway CD103+ and CD11b+ dendritic cells to suppress allergic inflammation

2015 ◽  
Vol 9 (1) ◽  
pp. 229-239 ◽  
Author(s):  
N J Daniels ◽  
E Hyde ◽  
S Ghosh ◽  
K Seo ◽  
K M Price ◽  
...  
Keyword(s):  
Dendritic Cells ◽  
T Lymphocytes ◽  
Cytotoxic T Lymphocytes ◽  
Allergic Inflammation
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