scholarly journals Antigenic Experience Dictates Functional Role of Glycogen Synthase Kinase-3 in Human CD4+ T Cell Responses

2008 ◽  
Vol 181 (12) ◽  
pp. 8363-8371 ◽  
Author(s):  
Carlos A. Garcia ◽  
Manjunatha R. Benakanakere ◽  
Pascale Alard ◽  
Michelle M. Kosiewicz ◽  
Denis F. Kinane ◽  
...  
Keyword(s):  
T Cell ◽  
Functional Role ◽  
Glycogen Synthase ◽  
T Cell Responses ◽  
Cd4 T Cell ◽  
Glycogen Synthase Kinase ◽  
Glycogen Synthase Kinase 3 ◽  
Cell Responses

scholarly journals Glycogen Synthase Kinase 3 Inactivation Drives T-bet-Mediated Downregulation of Co-receptor PD-1 to Enhance CD8+ Cytolytic T Cell Responses

Immunity ◽  
2016 ◽  
Vol 44 (2) ◽  
pp. 274-286 ◽  
Author(s):  
Alison Taylor ◽  
James A. Harker ◽  
Kittiphat Chanthong ◽  
Philip G. Stevenson ◽  
Elina I. Zuniga ◽  
...  
Keyword(s):  
T Cell ◽  
Glycogen Synthase ◽  
T Cell Responses ◽  
Glycogen Synthase Kinase ◽  
Glycogen Synthase Kinase 3 ◽  
Cell Responses

The role of CD4+ T cell responses in antitumor immunity

1998 ◽  
Vol 10 (5) ◽  
pp. 588-594 ◽  
Author(s):  
Drew M Pardoll ◽  
Suzanne L Topalian
Keyword(s):  
T Cell ◽  
Antitumor Immunity ◽  
T Cell Responses ◽  
Cd4 T Cell ◽  
Cell Responses

scholarly journals Glycogen synthase kinase-3-mediated phosphorylation of serine 73 targets sterol response element binding protein-1c (SREBP-1c) for proteasomal degradation

2016 ◽  
Vol 36 (1) ◽  
Author(s):  
Qingming Dong ◽  
Francesco Giorgianni ◽  
Sarka Beranova-Giorgianni ◽  
Xiong Deng ◽  
Robert N. O'Meally ◽  
...  
Keyword(s):  
Functional Role ◽  
Glycogen Synthase ◽  
Proteasomal Degradation ◽  
Glycogen Synthase Kinase ◽  
Glycogen Synthase Kinase 3 ◽  
Response Element ◽  
Element Binding Protein ◽  
Gsk 3Β

We have identified Serine 73 as a novel GSK-3β site on SREBP-1c that alters its affinity for SCAP, and proteasomal degradation. Phosphorylation of Serine 73 by GSK-3β during starvation (insulin-depleted stat) may lead to lower levels of SREBP-1c; conversely, de-phosphorylation of this site may be involved in stabilizing SREBP-1c by insulin (by blocking GSK-3β action). A functional role of this site needs to be corroborated in vivo.

A central role of CD40 ligand in the regulation of CD4+ T-cell responses

1996 ◽  
Vol 17 (9) ◽  
pp. 410-414 ◽  
Author(s):  
Iqbal S. Grewal ◽  
Richard A. Flavell
Keyword(s):  
T Cell ◽  
T Cell Responses ◽  
Cd40 Ligand ◽  
Cd4 T Cell ◽  
Cell Responses

scholarly journals Role of IL-33 in modulating human allergen specific CD4+ T cell responses

2017 ◽  
Vol 139 (2) ◽  
pp. AB88
Author(s):  
Nahir Garabatos ◽  
Veronique Bajzik ◽  
Blake J. Rust ◽  
Marco Londei ◽  
Erik R. Wambre
Keyword(s):  
T Cell ◽  
T Cell Responses ◽  
Cd4 T Cell ◽  
Cell Responses

scholarly journals The role of the SLAM-SAP signaling pathway in the modulation of CD4+ T cell responses

2011 ◽  
Vol 44 (4) ◽  
pp. 276-282 ◽  
Author(s):  
M.L.L.V. Vilar ◽  
M.S. Frutuoso ◽  
S.M. Arruda ◽  
D.M. Lima ◽  
C.S. Bezerra ◽  
...  
Keyword(s):  
T Cell ◽  
Signaling Pathway ◽  
T Cell Responses ◽  
Cd4 T Cell ◽  
Cell Responses
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