scholarly journals Clinical Outcome of Beta-Tricalcium Phosphate Use for Bone Defects after Operative Treatment of Benign Tumors

2019 ◽  
Vol 11 (2) ◽  
pp. 233 ◽  
Author(s):  
Haksun Chung ◽  
Sanghyo Kim ◽  
So Hak Chung
Keyword(s):  
Clinical Outcome ◽  
Operative Treatment ◽  
Tricalcium Phosphate ◽  
Bone Defects ◽  
Benign Tumors ◽  
Beta Tricalcium Phosphate

Repairing of Osteochondral Defects in Joint Using Beta-TCP/ Carboxymethyl Chitin Composite

2005 ◽  
Vol 284-286 ◽  
pp. 791-794 ◽  
Author(s):  
Shingo Masuda ◽  
Yusuke Yoshihara ◽  
Kazuaki Muramatsu ◽  
Izumi Wakebe
Keyword(s):  
Mechanical Properties ◽  
Articular Cartilage ◽  
Tricalcium Phosphate ◽  
Bone Repair ◽  
Bone Defects ◽  
Promising Material ◽  
Osteochondral Defects ◽  
Repair Rate ◽  
Beta Tricalcium Phosphate

Beta-tricalcium phosphate/carboxymethyl chitin composites [TCP/CMCh] of various ratios of TCP granules and CMCh were made and their mechanical properties, handling properties and repair performance for bone defects and for osteochondral defects were investigated. Water pooling ratio of CMCh was approximately 40 times the weight itself. TCP/CMCh of a higher TCP ratio had higher stress at 50%-strain. The stress at 50%-strain of TCP/CMCh with 0, 2.5, 5.0, 7.5, 10 TCP ratios was 0.12, 0.51, 1.08, 1.46, 1.67 (MPa, n=5), respectively. The TCP/CMCh with 5.0 TCP ratios had the best total scores in handling tests. The bone repair rate of TCP/CMCh was TCP ratio 2.5< Blank= TCP ratio 7.5< TCP ratio 5.0. In the implantation test for osteochondral defects, TCP/CMCh was completely absorbed at four weeks after surgery. Regeneration of the articular cartilage was seen with TCP/CMCh and HA/CMCh but not with TCP granules, which remained eight weeks after implantation. The regenerated articular cartilage had remained 32 weeks after implantation. In conclusion, it was demonstrated that this TCP/CMCh composite was a promising material for repairing osteochondral defects.

scholarly journals Histomorphometric, Immunohistochemical, Ultrastructural Characterization of a Nano-Hydroxyapatite/Beta-Tricalcium Phosphate Composite and a Bone Xenograft in Sub-Critical Size Bone Defect in Rat Calvaria

Materials ◽  
2020 ◽  
Vol 13 (20) ◽  
pp. 4598
Author(s):  
Igor da Silva Brum ◽  
Lucio Frigo ◽  
Renan Lana Devita ◽  
Jorge Luís da Silva Pires ◽  
Victor Hugo Vieira de Oliveira ◽  
...  
Keyword(s):  
Tricalcium Phosphate ◽  
Periodic Acid ◽  
Bone Defects ◽  
Cellular Mechanisms ◽  
Periodic Acid Schiff ◽  
Beta Tricalcium Phosphate ◽  
Rat Calvaria ◽  
Tnf Α ◽  
Group 2 ◽  
Living Tissues

Nowadays, we can observe a worldwide trend towards the development of synthetic biomaterials. Several studies have been conducted to better understand the cellular mechanisms involved in the processes of inflammation and bone healing related to living tissues. The aim of this study was to evaluate tissue behaviors of two different types of biomaterials: synthetic nano-hydroxyapatite/beta-tricalcium phosphate composite and bone xenograft in sub-critical bone defects in rat calvaria. Twenty-four rats underwent experimental surgery in which two 3 mm defects in each cavity were tested. Rats were divided into two groups: Group 1 used xenogen hydroxyapatite (Bio Oss™); Group 2 used synthetic nano-hydroxyapatite/beta-tricalcium phosphate (Blue Bone™). Sixty days after surgery, calvaria bone defects were filled with biomaterial, animals were euthanized, and tissues were stained with Masson’s trichrome and periodic acid–Schiff (PAS) techniques, immune-labeled with anti-TNF-α and anti-MMP-9, and electron microscopy analyses were also performed. Histomorphometric analysis indicated a greater presence of protein matrix in Group 2, in addition to higher levels of TNF-α and MMP-9. Ultrastructural analysis showed that biomaterial fibroblasts were associated with the tissue regeneration stage. Paired statistical data indicated that Blue Bone™ can improve bone formation/remodeling when compared to biomaterials of xenogenous origin.

scholarly journals Promotion of normal healing of bone defects under estrogen deficiency by implantation of beta-tricalcium phosphate composed of rod-shaped particles

2013 ◽  
Vol 32 (2) ◽  
pp. 189-196 ◽  
Author(s):  
Eri Tatsukawa ◽  
Yoshinori Gonda ◽  
Masanobu Kamitakahara ◽  
Masaaki Matsuura ◽  
Masaru Ushijima ◽  
...  
Keyword(s):  
Tricalcium Phosphate ◽  
Bone Defects ◽  
Estrogen Deficiency ◽  
Beta Tricalcium Phosphate

Biologic Responses of Autogenous Bone and Beta-tricalcium Phosphate Ceramics Transplanted into Bone Defects to Orthodontic Forces

1996 ◽  
Vol 33 (4) ◽  
pp. 277-283 ◽  
Author(s):  
Mohammed Zakir Hossain ◽  
Shingo Kyomen ◽  
Kazuo Tanne
Keyword(s):  
Tricalcium Phosphate ◽  
Alveolar Bone ◽  
Tooth Movement ◽  
Root Resorption ◽  
Orthodontic Tooth Movement ◽  
Bone Defects ◽  
Autogenous Bone ◽  
Beta Tricalcium Phosphate ◽  
Orthodontic Forces ◽  
External Stimuli

This study was conducted to evaluate biologic responses of autogenous bone (particulate marrow and cancellous bone; PMCB) and beta-tricalcium phosphate ceramics (TCPC) to orthodontic stimuli. Nine dogs served as the experimental animals; three dogs underwent orthodontic tooth movement after grafting, three dogs received PMCB grafting without tooth movement, and three dogs received TCPC grafting without tooth movement. Immediately after extraction of the upper second and/or third incisors, the maxillary alveolar bone was resected bilaterally. Autogenous PMCB obtained from the iliac bone and TCPC were transplanted into each bone defect. Experimental tooth movement was initiated 2 to 4 weeks after the grafting and continued for 9 to 15 weeks. Sectional archwires with open-coil springs were used for distal movement of the upper first incisors into the extraction sites. Oxytetracycline and calcein were employed as bone markers. Sections of grafted areas including the teeth were prepared for light and fluorescence microscopy. The results revealed that both autogenous bone and TCPC presented similar adaptive changes to the original alveolar bone without any external stimuli. TCPC exhibited more prominent biodegradative responses to orthodontic force in association with new cementum formation. Root resorption was also less in the TCPC area than in the PMCB region. It Is shown that TCPC is biodegradative In nature and adaptive for remodeling during orthodontic tooth movement. This finding indicates that TCPC may be a better biocompatible alternative to autogenous bone transplanted into bone defects subjected to orthodontic tooth movement.

Bone Morphogenetic Protein-2 Incorporated Beta-Tricalcium Phosphate Enhanced Bone Regeneration of Critical-Sized Bone Defects in Rats

2018 ◽  
Vol 782 ◽  
pp. 283-288 ◽  
Author(s):  
Ling Fei Wei ◽  
Gang Wu ◽  
Li Quan Deng ◽  
Yue Lian Liu
Keyword(s):  
Bone Regeneration ◽  
Bone Morphogenetic Protein ◽  
Tricalcium Phosphate ◽  
Histopathological Examination ◽  
Bone Defects ◽  
Biological Evaluation ◽  
Bone Morphogenetic Protein 2 ◽  
Beta Tricalcium Phosphate ◽  
Morphogenetic Protein ◽  
Autologous Bone

Although preclinical and clinical studies have shown the benefits of bone morphogenetic protein-2 (BMP2) in bone regeneration, there are increasing concerns about its side effects. These are mainly due to the high dosage of BMP2 which is necessary to obtain the desired clinical results. Previously our group has developed a novel controlled-release delivery system; the biomimetic calcium phosphate coating incorporated with BMP2. It can be used at much lower concentrations of BMP2 than those used in the commercially available product and still produce similar biological effects. In this study, we made a primarily biological evaluation of BMP2 incorporated beta-tricalcium phosphate (β-TCP) for bone regeneration in critical-sized bone defects. Critical-sized calvarial defects were created in rats. They were divided into four groups as follows: (1) empty defects (control), (2) defects filled with β-TCP, (3) defects filled with BMP2 incorporated β-TCP, (4) defects filled with autologous bone. Eight weeks after the operation, the efficiency of the materials was evaluated using histology and histomorphometry. Moreover, the safety of the materials was evaluated using routine blood examination, blood biochemistry examination and histopathological examination of viscera. BMP2 incorporated β-TCP demonstrated an efficiency of bone regeneration that was comparable with autologous bone, with the highest levels of new bone formation (38.3±8.4 mm3 versus 30.1±9.9 mm3, p < 0.05). All clinical lab index of blood in these four groups were within the normal range. Moreover, no change related to the treatment was noted in the histopathological examination of viscera. The results from the present study demonstrated that BMP2 incorporated β-TCP could be a promising substitute for autologous bone used for bone regeneration. Future clinical trials and preclinical trials with large animal models are necessary to investigate the safety and efficacy of BMP2 incorporated β-TCP.

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