scholarly journals Endobronchial Perineurioma: An Unusual Soft Tissue Lesion in an Unreported Location

2010 ◽  
Vol 2010 ◽  
pp. 1-4
Author(s):  
Lisa Duncan ◽  
Daryl R. Tharp ◽  
Paul Branca ◽  
Jim Lyons
Keyword(s):  
Soft Tissue ◽  
Epithelial Membrane Antigen ◽  
Smooth Muscle Actin ◽  
Benign Neoplasm ◽  
Spindle Cells ◽  
First Case ◽  
S 100 ◽  
Endobronchial Lesion ◽  
History Of ◽  
Cytoplasmic Processes

We report the first case of an endobronchial perineurioma, a rare benign neoplasm typically occurring in soft tissue. A 53-year-old nonsmoking female presented with a three-month history of persistent bronchitis. A CT scan followed by bronchoscopy demonstrated an endobronchial lesion involving the left mainstem bronchus. Removal of the lesion by bronchoscopy was accomplished. The tumor was composed of bland spindle cells in a variably collagenized stroma. These cells had long cytoplasmic processes. No mitotic activity or necrosis was observed. Neoplastic cells were immunoreactive for epithelial membrane antigen (EMA), CD34, and claudin-1. Smooth muscle actin (SMA), desmin, and S-100 immunostains were all negative. Based on the morphologic appearance and immunophenotype, a diagnosis of perineurioma was rendered.

Amianthoid Myofibroblastoma of the Soft Tissues

1997 ◽  
Vol 83 (5) ◽  
pp. 862-867 ◽  
Author(s):  
Alessandro Corsi ◽  
Francesca Diomedi Camassei ◽  
Cesare Bosman
Keyword(s):  
Soft Tissue ◽  
Soft Tissues ◽  
Epithelial Membrane Antigen ◽  
Smooth Muscle Actin ◽  
Protein Factor ◽  
Spindle Cells ◽  
Spindle Cell Proliferation ◽  
S 100 ◽  
Clinicopathologic Findings ◽  
Male Sex

Myofibroblastoma (MF) is an uncommon, usually benign, mesenchymal tumor infrequently described in soft tissues. We report here on the clinicopathologic findings of a soft tissue MF (STMF) presenting in the neck of a 90-year-old man as a slowly growing and non-painful nodule, 4 cm in greatest diameter. Histology revealed a circumscribed lesion constituted of monomorphous bipolar spindle cells arranged in swirling fascicles with intervening broad bands of hyalinized collagen and well formed “amianthoid” fibers. Immunohistochemistry showed the spindle cells to be immunoreactive for vimentin, smooth muscle actin and muscle specific actin and, focally, for desmin; im-munostaining for cytokeratin, epithelial membrane antigen, S-100 protein, factor VIII-related antigen, and CD34 was negative. Based on the present case and on those previously reported in the literature, STMF is characterized by: 1) exclusive incidence in the male sex; 2) variable immunoreactivity of the neoplastic cells for desmin, probably reflecting an origin from a peculiar subset of myofibroblasts, or, alternatively, a further myoid differentiation; 3) variable abundance of (hyalinized) collagen; 4) presence of amianthoid fibers. The combination of desmin immunoreactivity, frequently observed in MF of the breast, and amianthoid fibers, the main feature of MF of the lymph nodes, has never been observed in soft tissue MF. It is important to recognize STMF as a specific clinicopathologic entity to avoid confusion with other types of spindle cell proliferation and to differentiate it from other types of myofibromatosis.

scholarly journals Desmoplastic melanoma morphology on Thinprep: a report of two cases

CytoJournal ◽  
2007 ◽  
Vol 4 ◽  
pp. 18 ◽  
Author(s):  
Becky L Van Ells ◽  
James E Madory ◽  
Rana S Hoda
Keyword(s):  
Needle Aspiration ◽  
Excellent Correlation ◽  
Cytoplasmic Staining ◽  
Case Presentation ◽  
Fibrous Stroma ◽  
Desmoplastic Melanoma ◽  
Spindle Cells ◽  
First Case ◽  
S 100 ◽  
History Of

Background Desmoplastic melanoma is a variant of malignant melanoma that can range in appearance from sarcomatoid to scar-like. Cytomorphology of desmoplastic melanoma has been previously described on conventional smears; however, to our knowledge, detailed cytomorphology on ThinPrep has so far not been described. Herein, we describe the cytomorphology of two cases of desmoplastic melanoma on fine needle aspiration processed as ThinPrep slides and compare it to that seen on conventional smears. Pertinent immunocytochemical stains, performed on ThinPrep slides are also discussed. Case presentation The first case is a woman with a history of desmoplastic melanoma of the scalp with previous local recurrences and lymph node metastasis with a new submandibular mass. The second case is a man with a previously resected desmoplastic melanoma with his first local recurrence. Conventional smears, including air-dried Diff-Quik-stained and alcohol-fixed Papanicolaou-stained smears, demonstrated aggregates of pleomorphic spindle cells admixed with fibrous stroma and single spindle cells. In both cases, nuclei were elongated and plump with irregular nuclear contours, deep grooves, and folds. Chromatin was dark and coarse with either inconspicuous or multiple prominent nucleoli. Cytoplasm was located at the nuclear poles and was fine, wispy, and delicate. The background was clean with no evidence of necrosis or melanin pigment. Papanicolaou-stained ThinPrep slides were prepared from needle rinses and demonstrated excellent correlation of nuclear and cytoplasmic detail of single spindle cells to that seen on conventional smears with the exception of only slight decrease in nuclear size; however, nuclear and cytoplasmic detail of spindle cells embedded in stroma was markedly attenuated. Confirmatory immunostain for S-100 protein in both cases was performed on ThinPrep slides demonstrating crisp cytoplasmic staining in the spindle cells. Conclusion The cytomorphology of desmoplastic melanoma shows excellent correlation between cytomorphology of single spindle cells on conventional smears and on ThinPrep slides. The major difference noted on ThinPrep slides was attenuated nuclear and cytoplasmic detail of spindle cells embedded in fibrous stoma.

scholarly journals Preoperatively diagnosed gastric collision tumor with mixed adenocarcinoma and gastrointestinal stromal tumor: a case report and literature review

2021 ◽  
Author(s):  
Kunihiko Matsuno ◽  
Yoshikazu Kanazawa ◽  
Daisuke Kakinuma ◽  
Nobutoshi Hagiwara ◽  
Fumihiko Ando ◽  
...  
Keyword(s):  
Gastrointestinal Stromal Tumor ◽  
Distal Gastrectomy ◽  
Submucosal Tumor ◽  
Smooth Muscle Actin ◽  
Collision Tumor ◽  
Stromal Tumor ◽  
Lower Body ◽  
Muscle Actin ◽  
First Case ◽  
S 100

AbstractReports of gastric collision tumors, comprising adenocarcinoma and gastrointestinal stromal tumor, are extremely rare. Here, we report the case of a 68-year-old male who was diagnosed with a lower-body, moderately differentiated, tubular-type adenocarcinoma and submucosal tumor and underwent an elective D2 distal gastrectomy. The tumor cells of the gastrointestinal stromal tumor were positive for H-caldesmon and CD117, weakly positive for smooth muscle actin and DOG-1, and negative for desmin, S-100 protein, CD31, and AE1/AE3. The tumor had grown into a mixed form of adenocarcinoma and gastrointestinal stromal tumor. Thus, we report the first case of a preoperatively diagnosed collision tumor in the stomach consisting of adenocarcinoma and gastrointestinal stromal tumor.

Myofibroma of the Gingiva: Report of a Case

2010 ◽  
Vol 34 (3) ◽  
pp. 253-257 ◽  
Author(s):  
Banu Özveri Koyuncu ◽  
Mert Zeytinoğlu ◽  
Taha Ünal ◽  
Bülent Zeytinoğlu
Keyword(s):  
Benign Tumor ◽  
Smooth Muscle Actin ◽  
Correct Diagnosis ◽  
Benign Neoplasm ◽  
Surgical Excision ◽  
Solitary Lesion ◽  
Immunohistochemical Markers ◽  
Mesenchymal Neoplasm ◽  
S 100 ◽  
Histopathologic Evaluation

Myofibroma is a benign mesenchymal neoplasm composed of myofibroblasts which has been described with different synonyms since the first report in 1951. It occurs most commonly as a solitary lesion of soft tissue,skin, or bone in infancy. The prognosis of oral myofibromas is excellent, and surgical excision is curative. Recurrence is rare. Awareness and recognition of this benign tumor is important to establish the correct diagnosis and avoid morbidity of unnecessary aggressive therapy. This report describes a myofibroma of the gingiva in a 14 year old girl and is reported together with the conventional histologic, and immunohistochemical findings. The tumor showed rapid increase in size and clinical features suggestive of malignancy. However, on histopathologic evaluation it was diagnosed as a benign neoplasm, and this diagnosis was supported by immunohistochemical markers. The spindle cells were immunopositive for smooth muscle actin,and vimentin but were negative for desmin and S-100 protein. The patient was treated with surgical excision,and is followed-up for 33 months without any signs of recurrence.

Epithelioid Leiomyosarcoma of the External Deep Soft Tissue

2002 ◽  
Vol 126 (4) ◽  
pp. 468-470 ◽  
Author(s):  
Tetsuji Yamamoto ◽  
Rieko Minami ◽  
Chiho Ohbayashi ◽  
Mayumi Inaba
Keyword(s):  
Soft Tissue ◽  
Tumor Cells ◽  
Epithelial Membrane Antigen ◽  
Spindle Cell ◽  
Smooth Muscle Actin ◽  
S100 Protein ◽  
Immunohistochemical Analysis ◽  
Deep Soft Tissue ◽  
Cell Component ◽  
Spindle Cell Component

Abstract Epithelioid leiomyosarcoma in the external deep soft tissue is extremely rare. Most epithelioid leiomyosarcomas occur in the uterus. We present a case of epithelioid leiomyosarcoma occurring in the muscle of the thigh of a 78-year-old man. Histologically, the tumor predominantly consisted of round or polygonal cells arranged in sheets with a focal spindle cell component. Immunohistochemical analysis revealed that the tumor cells expressed vimentin, α-smooth muscle actin, and α-sarcomeric actin. The tumor was negative for desmin, S100 protein, glial fibrillary acidic protein, pan-keratin, epithelial membrane antigen, CAM 5.2, HMB-45, leukocyte common antigen, factor VIII–associated antigen, and CD34. Electron microscopically, some tumor cells contained abundant actin-type filaments in their cytoplasm.

scholarly journals A Review of the Literature on Primary Leiomyosarcoma of the Prostate Gland

2015 ◽  
Vol 2015 ◽  
pp. 1-15 ◽  
Author(s):  
Anthony Kodzo-Grey Venyo
Keyword(s):  
Cytogenetic Study ◽  
Smooth Muscle Actin ◽  
Prostate Gland ◽  
Hormonal Treatment ◽  
Previous Treatment ◽  
Multicenter Trial ◽  
Perineal Pain ◽  
S 100 ◽  
History Of ◽  
Primary Leiomyosarcoma

Primary leiomyosarcoma of the prostate (PLSOP) is rare, with less than 200 cases reported so far. PLSOPs present with lower urinary tract symptoms, haematuria, and perineal pain; may or may not be associated with a history of previous treatment for adenocarcinoma of prostate by means of radiotherapy and or hormonal treatment; may afflict children and adult male. Examination may reveal benign enlarged prostate and hard enlarged mass. PLSOPs may be diagnosed by histological examination findings of spindle-shaped carcinoma cells in prostate specimens. Immunohistochemical staining tends to be positive for vimentin, CD44, smooth muscle actin, and calponin, focally positive for desmin, and at times positive for keratin. They stain negatively for PSA, S-100, CD34, CD117, and cytokeratin. Cytogenetic study on primary leiomyosarcoma of the prostate gland may show clonal chromosomal rearrangement involving Chromosomes 2, 3, 9, 11, and 19. On the whole the prognosis is poor. Surgery with or without chemotherapy would appear to be the mainstay of treatment for PLSOPs that are operable, but generally there is no consensus opinion on the best therapeutic approach. Most cases of PLSOPs are diagnosed in an advanced stage of the disease. A global multicenter trial is required to find therapies that would improve the prognosis.

scholarly journals Spinal Canal Involvement in Solitary Infantile Myofibromatosis: Case Report

2017 ◽  
Vol 06 (03) ◽  
pp. 223-227
Author(s):  
S.N. Gautam ◽  
Siddharth Mittal
Keyword(s):  
Spinal Canal ◽  
Smooth Muscle Actin ◽  
Lower Limbs ◽  
Nerve Sheath Tumor ◽  
Infantile Myofibromatosis ◽  
Nerve Sheath ◽  
Biopsy Report ◽  
S 100 ◽  
History Of ◽  
Intradural Space

AbstractInfantile myofibromatosis involving the spinal canal is very rare; only 11 cases have been reported so far in the literature. The authors present a case of an 18-month-old male child who presented with the history of dribbling of urine and weakness in bilateral lower limbs since 2 months. MRI of spine revealed single intramedullary intradural space-occupying lesion (SOL) at D1 to D2.The patient underwent laminectomy with excision of SOL with biopsy report suggestive of benign nerve sheath tumor, and immunohistochemistry report revealed desmin negative, smooth muscle actin positive, and S-100 focally positive infantile myofibromatosis. The patient gradually recovered and had a clear stream of urine with improved movements and tone of bilateral lower limbs at the time of discharge.

CASE REPORT : LIPOSARCOMA OF THE SHOULDER

2021 ◽  
pp. 35-36
Author(s):  
Tannistha Chakraborty ◽  
Vamsi Krishna ◽  
T. Raghupathy
Keyword(s):  
Soft Tissue ◽  
Soft Tissue Tumor ◽  
Benign Neoplasm ◽  
Soft Tissue Tumours ◽  
Long Duration ◽  
Cutaneous Localization ◽  
History Of ◽  
Local Radiation ◽  
The Right ◽  
Malignant Soft Tissue

Lipoma, a benign neoplasm of adipocytes, is the most common mesenchymal soft tissue tumor of adulthood, but rarely present with huge sizes in their cutaneous localization. Liposarcomas are the second most common soft tissue sarcoma following malignant brous histiocytoma. They comprise approximately 16-18% of all malignant soft tissue tumours. It is most common in the trunk followed by lower extremity, upper extremity and head and neck.. While lipomas can be clinically diagnosed , transformation of lipomas into liposarcoma is rare. Here we report the case of a 55 gentleman, who came with a history of swelling over the right shoulder with a probable malignant transformation due to history of long duration of presence of swelling. Management is usually by wide excision. Local radiation and chemotherapy may be necessary for high grade lesions.

scholarly journals Fibrosarcoma of Mandible: A Case Report

2011 ◽  
Vol 2011 ◽  
pp. 1-4
Author(s):  
Monal B. Yuwanati ◽  
J. V. Tupkari
Keyword(s):  
Smooth Muscle Actin ◽  
Third Molar ◽  
Final Diagnosis ◽  
Posterior Teeth ◽  
Mandibular Third Molar ◽  
Mesenchymal Neoplasm ◽  
S 100 ◽  
History Of ◽  
Posterior Area ◽  
Molar Region

Fibrosarcoma is a malignant mesenchymal neoplasm of fibroblasts that rarely affects the oral cavity and can cause local recurrences or metastasis. In this paper, a case of fibrosarcoma in the posterior area of mandible in a 44-year-old woman is described. Clinical examination revealed a growth on right mandibular third molar region extending on the buccal and the lingual side. There was history of extraction of posterior teeth. Radiologically, there was a diffuse bone loss. Microscopically, the tumor showed an intense proliferation of fibroblasts of variable size and shape. These cells were arranged in parallel bands and partly crossing each other. The cells exhibited increased mitotic activity and nuclear pleomorphism. Immunohistochemically the cells showed immunoreactivity only for vimentin while they exhibited negativity towards S-100 protein, cytokeratin cocktail, HMB-45, desmin, smooth muscle actin, and epithelial membrane antigen (EMA). Based on findings the final diagnosis of fibrosarcoma was made.

Orbital (Retrobulbar) Meningioma in a Simmental Cow

2007 ◽  
Vol 44 (4) ◽  
pp. 504-507 ◽  
Author(s):  
J. L. Reis ◽  
C. T. Kanamura ◽  
G. M. Machado ◽  
R. O. França ◽  
J. R. J. Borges ◽  
...  
Keyword(s):  
Electron Microscopy ◽  
Epithelial Membrane Antigen ◽  
Smooth Muscle Actin ◽  
Neuron Specific Enolase ◽  
Muscle Actin ◽  
Transmission Electron ◽  
S 100 ◽  
Poorly Differentiated ◽  
The Right ◽  
Mib 1

A 12-year-old Simmental cow was presented with a moderately firm irregular whitish mass of approximately 5 cm in diameter, occupying the right orbit. Microscopically, a poorly differentiated neoplasm was observed. The immunohistochemical panel included cytokeratins, vimentin, epithelial membrane antigen, Factor VIII, CD34, Mart-1, Melan A, smooth muscle actin, desmin, chromogranin, neuron-specific enolase, S-100 protein, and MIB-1. The neoplasm was negative for all of them, with the exception of vimentin and S-100 protein. Transmission electron microscopy revealed abundant desmosomes. These findings support the diagnosis of orbital (retrobulbar) meningioma.

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