Orbital (Retrobulbar) Meningioma in a Simmental Cow

2007 ◽  
Vol 44 (4) ◽  
pp. 504-507 ◽  
Author(s):  
J. L. Reis ◽  
C. T. Kanamura ◽  
G. M. Machado ◽  
R. O. França ◽  
J. R. J. Borges ◽  
...  
Keyword(s):  
Electron Microscopy ◽  
Epithelial Membrane Antigen ◽  
Smooth Muscle Actin ◽  
Neuron Specific Enolase ◽  
Muscle Actin ◽  
Transmission Electron ◽  
S 100 ◽  
Poorly Differentiated ◽  
The Right ◽  
Mib 1

A 12-year-old Simmental cow was presented with a moderately firm irregular whitish mass of approximately 5 cm in diameter, occupying the right orbit. Microscopically, a poorly differentiated neoplasm was observed. The immunohistochemical panel included cytokeratins, vimentin, epithelial membrane antigen, Factor VIII, CD34, Mart-1, Melan A, smooth muscle actin, desmin, chromogranin, neuron-specific enolase, S-100 protein, and MIB-1. The neoplasm was negative for all of them, with the exception of vimentin and S-100 protein. Transmission electron microscopy revealed abundant desmosomes. These findings support the diagnosis of orbital (retrobulbar) meningioma.

Glomus Tumor in the Digit of a Cat

2002 ◽  
Vol 39 (5) ◽  
pp. 590-592 ◽  
Author(s):  
K. Uchida ◽  
R. Yamaguchi ◽  
S. Tateyama
Keyword(s):  
Glomus Tumor ◽  
Smooth Muscle Actin ◽  
Neuron Specific Enolase ◽  
Outer Side ◽  
Muscle Actin ◽  
Epithelioid Cells ◽  
Alpha Smooth Muscle Actin ◽  
The Third ◽  
Pathologic Features ◽  
S 100

A solitary mass approximately 1.5 X 2 cm located on the outer side of the third digit of the left forepaw of a 7-year-old male cross-breed cat was examined pathologically. The excised tumor mass was hard and white and located within the deep dermis and subcutis. Histopathologically, the mass consisted of a mixed population of small round epithelioid cells arranged in ribbon- or cordlike structures and spindle-shaped cells forming loose irregular bundles in a mucinous stroma. The epithelioid cells were often arranged around small blood vessels. Neoplastic cells were intensely positive for vimentin and alpha smooth muscle actin and negative for keratin, desmin, S-100 protein, and neuron-specific enolase. Based on these pathologic features, the tumor was diagnosed as a glomus tumor, a neoplasm not previously reported in cats and extremely rare in animals.

scholarly journals Malignant Melanocytic Neural Crest Tumor in a Young Chicken (Gallus domesticus)

1995 ◽  
Vol 32 (5) ◽  
pp. 535-537 ◽  
Author(s):  
S. Hafner ◽  
K. Latimer ◽  
L. C. Kelley ◽  
K. Wortham ◽  
M. Puette
Keyword(s):  
Electron Microscopy ◽  
Transmission Electron Microscopy ◽  
Ganglion Cells ◽  
Neuron Specific Enolase ◽  
Gallus Domesticus ◽  
Specific Staining ◽  
Melanocytic Tumor ◽  
Transmission Electron ◽  
S 100 ◽  
Young Chicken

A malignant melanocytic tumor was found in an 8-week-old chicken. The tumor, which was composed of melanocytes, ganglion cells, nerves, and primitive pressure receptors, was examined by light microscopy, transmission electron microscopy, and immunohistochemistry. Antibodies to neuron-specific enolase (NSE), glial fibrillary acidic protein (GFAP), and S-100 protein variably stained nerves, but melanocytes were only rarely immunolabelled by NSE antibodies and there was no specific staining of these cells for S-100 or GFAP. Ultrastructurally, neoplastic melanocytes contained melanin within melanosomes and premelanosomes and did not resemble Schwann cells.

Pilomatrix Carcinoma. A Case Report with Immunohistochemical Findings, Flow Cytometric Comparison with Benign Pilomatrixoma and Review of the Literature

1994 ◽  
Vol 80 (4) ◽  
pp. 309-314 ◽  
Author(s):  
Luigi Panico ◽  
J. Carlos Manivel ◽  
Guido Pettinato ◽  
Nicolina De Rosa ◽  
Angela Ruggiero ◽  
...  
Keyword(s):  
Blood Group ◽  
Epithelial Membrane Antigen ◽  
Neuron Specific Enolase ◽  
Blood Group Antigens ◽  
Peanut Agglutinin ◽  
Squamous Cells ◽  
S 100 ◽  
Subcutaneous Mass ◽  
The Right ◽  
Pilomatrix Carcinoma

We report a case of pilomatrix carcinoma in a 42 year old woman. The patient presented a rapidly growing 4-cm subcutaneous mass in the right preauricular area. She was free of recurrence 24 months after surgery. Immunoreactivity was studied for cytokeratins, epithelial membrane antigen, S-100 protein, blood group antigens, Leu-M1, β-2-microglobulin, vimentin, neuron-specific-enolase and cellular binding for peanut agglutinin. Squamous cells were reactive for cytokeratin AE1/3, epithelial membrane antigen, blood group antigens B and H, and peanut agglutinin. Basaloid cells were focally reactive for cytokeratin AE1/3 and epithelial membrane antigen. Flow cytometry revealed a euploid DNA content and a high proliferative rate of the pilomatrix carcinoma and in benign pilomatrixoma studied for comparison. The pathological diagnosis must be based on histomorphological criteria.

Development of an Atypical Teratoid Rhabdoid Tumor in a Meningioma

2017 ◽  
Vol 25 (6) ◽  
pp. 567-572 ◽  
Author(s):  
Boleslaw Lach ◽  
Michelle Kameda-Smith ◽  
Sheila Singh ◽  
Olufemi Ajani
Keyword(s):  
Epithelial Membrane Antigen ◽  
Smooth Muscle Actin ◽  
Rhabdoid Tumor ◽  
Low Grade ◽  
Recurrent Tumor ◽  
Atypical Teratoid Rhabdoid Tumor ◽  
Muscle Actin ◽  
Anaplastic Meningioma ◽  
S 100 ◽  
Atypical Teratoid

We describe an atypical teratoid rhabdoid tumor (AT/RT) with a component of low-grade and anaplastic rhabdoid meningioma in a 7-year-old child. The AT/RT was uniformly negative for INI1 and displayed immunoreactivity for vimentin, P53, CD99, cytokeratins with AE1/AE3 antibodies, epithelial membrane antigen, β-catenin, smooth muscle actin, E-cadherin, and S-100 protein. AT/RT was continuous, with small foci of recognizable low-grade and anaplastic meningioma. The low-grade meningioma was INI1 positive with scattered INI1-negative nuclei, whereas the remaining tumor components were INI1 negative. A recurrent tumor 6 months after partial resection contained only INI1-negative AT/RT. This case supports the hypothesis that rare examples of AT/RT may emerge from a preexisting “parent” neoplasm as a result of a second hit mutation.

Electron Microscopy in Tumor Diagnosis in 2001

2001 ◽  
Vol 7 (S2) ◽  
pp. 590-591
Author(s):  
J. Shelburne ◽  
D. Howell
Keyword(s):  
Electron Microscopy ◽  
Cell Biology ◽  
Tumor Diagnosis ◽  
Electron Microscopic ◽  
Transmission Electron ◽  
Transmission Electron Microscopic ◽  
S 100 ◽  
Molecular Information ◽  
Diagnostic Work ◽  
The Right

Immunohistochemistry (IH) has revolutionized tumor diagnosis in recent years. The antigenic/molecular information now available is extraordinarily helpful not only in clinical diagnostic work, but also in improving our understanding of the cell biology of neoplasia. As a result, there is now less need for diagnostic conventional transmission electron microscopic (CTEM) studies on neoplasms. For example, lymphomas and leukemias are now largely defined by IH and related techniques such as flow cytometry, not CTEM. A postive S-100 stain in the right setting usually obviates the need to search for melanosomes.However, CTEM is still a useful tool for surgical pathologists. One important advantage CTEM has over IH is that - like gross observations and the classic H&E section - CTEM can detect features not suspected in advance. This property of CTEM makes it particularly valuable in studying complex and unusual patients/tumors.

scholarly journals Piloleiomyosarcoma in cats: Histological and immunohistochemical features

2021 ◽  
pp. 030098582110425
Author(s):  
Francisco Rodríguez Guisado ◽  
Pedro Luis Castro
Keyword(s):  
Smooth Muscle ◽  
Subcutaneous Tissue ◽  
Smooth Muscle Actin ◽  
Neuron Specific Enolase ◽  
Surgical Excision ◽  
Giant Cells ◽  
Hair Follicles ◽  
Muscle Actin ◽  
Neoplastic Cells ◽  
S 100

This study describes the histomorphology and immunohistochemical profile of 9 cases of feline piloleiomyosarcoma. Cats ranged in age from 7 to 16 years (mean 10), and tumors were 7 to 24 mm in diameter (mean 15). Tumors were composed of fusiform cells that were haphazardly arranged or in variably sized interwoven bundles. Neoplastic cells had eosinophilic and fibrillar cytoplasm, and elongated blunt-ended nuclei. Entrapment of hair follicles and absence of vascular components support an origin from the smooth muscle cells of the arrector pili. Additional findings included bizarre nuclei and giant cells (7/9 cases), atypical mitoses (7/9 cases), ulceration (3/9 cases), and intratumoral necrosis (6/9 cases). Neoplastic cells expressed calponin, desmin, α-smooth muscle actin, and vimentin, but not CD18, CD31, cytokeratins, glial fibrillary acidic protein, neuron-specific enolase, Melan A, p63, or S-100 protein. Surgical excision was curative in 6/9 cases, with local recurrence in 2/9 cases and metastasis to local lymph nodes in 1/9 case. Clinical outcome was influenced by mitotic count, infiltration of subcutaneous tissue, and intensity of nuclear immunolabeling for p53.

scholarly journals Immunohistochemical Characteristics of Normal Canine Eyes

2011 ◽  
Vol 49 (5) ◽  
pp. 860-869 ◽  
Author(s):  
P. Labelle ◽  
C. M. Reilly ◽  
D. K. Naydan ◽  
A. L. Labelle
Keyword(s):  
Normal Tissue ◽  
Smooth Muscle Actin ◽  
Pigment Epithelium ◽  
Retinal Pigment ◽  
Neuron Specific Enolase ◽  
Cytokeratin 20 ◽  
Muscle Actin ◽  
Cytokeratin 7 ◽  
S 100 ◽  
Microphthalmia Transcription Factor

Immunohistochemistry is widely utilized in diagnostic laboratories to study neoplastic and nonneoplastic diseases. Knowledge of the immunohistochemical characteristics of normal tissue is essential for interpretation of immunoreactivity in pathologic conditions. In this study, immunohistochemistry was performed with a broad panel of diagnostically relevant antibodies on 4 normal canine globes—namely, vimentin, pan-cytokeratin (AE1/AE3), cytokeratin 7, cytokeratin 8/18, cytokeratin 20, α–smooth muscle actin, muscle specific actin, desmin, Melan-A, microphthalmia transcription factor, S-100, glial fibrillary acidic protein, triple neurofilaments, neuron-specific enolase, chromogranin A, synaptophysin, laminin and CD31. Results include cytokeratin immunoreactivity limited to the conjunctival epithelium, corneal epithelium, and retinal pigment epithelium; distinct patterns of immunopositivity of muscle markers; and widespread immunoreactivity for vimentin and most neural/neuroendocrine markers. These findings in normal eyes provide the basis for interpretation of ocular immunohistochemistry in dogs. Published immunophenotypes of primary ocular neoplasms are also reviewed.

Omental Leiomyoma in a Male Adult Horse

2007 ◽  
Vol 44 (5) ◽  
pp. 722-726 ◽  
Author(s):  
D. Schaudien ◽  
J. M. V. Müller ◽  
W. Baumgärtner
Keyword(s):  
Smooth Muscle ◽  
Gastrointestinal Tract ◽  
Tumor Cells ◽  
Smooth Muscle Actin ◽  
Neuron Specific Enolase ◽  
Muscle Actin ◽  
Male Adult ◽  
S 100 ◽  
Multiple Cysts ◽  
Histology And Immunohistochemistry

A well-circumscribed mass 70 X 35 X 28 cm in size and 41 kg in weight was detected at necropsy in a male adult horse within the omentum major without any association to the gastrointestinal tract. The tumor consisted of multiple white-to-yellow lobules and displayed a firm consistency. In addition, multiple cysts filled with blood-like fluid, and multifocal areas of necrosis were observed. Histologically, the mass consisted of slightly pleomorphic spindloid-shaped cells arranged in interlacing bundles containing elongated nuclei with blunt ends. The majority of tumor cells revealed a positive immunoreaction for α-smooth muscle actin, vimentin, and neuron-specific enolase and were negative for S-100, factor VIII-related antigen, and glial fibrillary acidic protein. Few tumor cells showed expression of desmin and c-kit. On the basis of macroscopy, histology, and immunohistochemistry, an omental leiomyoma was diagnosed.

scholarly journals Preoperatively diagnosed gastric collision tumor with mixed adenocarcinoma and gastrointestinal stromal tumor: a case report and literature review

2021 ◽  
Author(s):  
Kunihiko Matsuno ◽  
Yoshikazu Kanazawa ◽  
Daisuke Kakinuma ◽  
Nobutoshi Hagiwara ◽  
Fumihiko Ando ◽  
...  
Keyword(s):  
Gastrointestinal Stromal Tumor ◽  
Distal Gastrectomy ◽  
Submucosal Tumor ◽  
Smooth Muscle Actin ◽  
Collision Tumor ◽  
Stromal Tumor ◽  
Lower Body ◽  
Muscle Actin ◽  
First Case ◽  
S 100

AbstractReports of gastric collision tumors, comprising adenocarcinoma and gastrointestinal stromal tumor, are extremely rare. Here, we report the case of a 68-year-old male who was diagnosed with a lower-body, moderately differentiated, tubular-type adenocarcinoma and submucosal tumor and underwent an elective D2 distal gastrectomy. The tumor cells of the gastrointestinal stromal tumor were positive for H-caldesmon and CD117, weakly positive for smooth muscle actin and DOG-1, and negative for desmin, S-100 protein, CD31, and AE1/AE3. The tumor had grown into a mixed form of adenocarcinoma and gastrointestinal stromal tumor. Thus, we report the first case of a preoperatively diagnosed collision tumor in the stomach consisting of adenocarcinoma and gastrointestinal stromal tumor.

Oncocytic Lipoadenoma: Report of 3 Rare Cases Involving the Parotid Gland, Including a Synchronous Presentation With Paraganglioma of the Right Carotid Bifurcation and Literature Review

2021 ◽  
pp. 106689692110219
Author(s):  
John L.S. Cunha ◽  
Marco A. Peñalonzo ◽  
Ciro D. Soares ◽  
Bruno A.B. de Andrade ◽  
Mário J. Romañach ◽  
...  
Keyword(s):  
English Language ◽  
Smooth Muscle Actin ◽  
Salivary Gland Tumor ◽  
Surgical Excision ◽  
Carotid Bifurcation ◽  
Alpha Smooth Muscle Actin ◽  
S 100 ◽  
The Right ◽  
Adequate Management ◽  
Adipose Cells

Oncocytic lipoadenoma (OL) is a rare salivary gland tumor characterized by the presence of oncocytic cells and mature adipose tissue. To date, only 30 cases of OL have been reported in the English-language literature. We present 3 additional OL cases involving the parotid, including a synchronous presentation with paraganglioma of the right carotid bifurcation. Microscopically, both the OLs were composed of a mixed population of oncocytes and adipocytes in varying proportions surrounded by a thin, connective tissue fibrous capsule. Oncocytes were positive for pan-cytokeratins (CKs) AE1/AE3, epithelial membrane antigen, CK5, CK7, CK14, CK18, and CK19. Calponin, p63, alpha-smooth muscle actin, and carcinoembryonic antigen were negative. Vimentin and S-100 protein were positive only in adipose cells. Despite distinctive morphologic features, OL is often misdiagnosed, given its rarity. We hope to contribute to surgeons’ and pathologists’ awareness and knowledge regarding the existence of this tumor and provide adequate management through conservative surgical excision.

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