scholarly journals Manganese Inhalation as a Parkinson Disease Model

2011 ◽  
Vol 2011 ◽  
pp. 1-14 ◽  
Author(s):  
José Luis Ordoñez-Librado ◽  
Verónica Anaya-Martínez ◽  
Ana Luisa Gutierrez-Valdez ◽  
Laura Colín-Barenque ◽  
Enrique Montiel-Flores ◽  
...  
Keyword(s):  
Parkinson Disease ◽  
Disease Model ◽  
Manganese Acetate ◽  
Male Mice ◽  
Behavioral Alterations ◽  
Action Tremor ◽  
Dopaminergic Cell ◽  
Dopamine Content ◽  
Motor Disturbances ◽  
Motor Alterations

The present study examines the effects of divalent and trivalent Manganese (Mn2+/Mn3+) mixture inhalation on mice to obtain a novel animal model of Parkinson disease (PD) inducing bilateral and progressive dopaminergic cell death, correlate those alterations with motor disturbances, and determine whetherL-DOPA treatment improves the behavior, to ensure that the alterations are of dopaminergic origin. CD-1 male mice inhaled a mixture of Manganese chloride and Manganese acetate, one hour twice a week for five months. Before Mn exposure, animals were trained to perform motor function tests and were evaluated each week after the exposure. By the end of Mn exposure, 10 mice were orally treated with 7.5 mg/kgL-DOPA. After 5 months of Mn mixture inhalation, striatal dopamine content decreased 71%, the SNc showed important reduction in the number of TH-immunopositive neurons, mice developed akinesia, postural instability, and action tremor; these motor alterations were reverted withL-DOPA treatment. Our data provide evidence that Mn2+/Mn3+mixture inhalation produces similar morphological, neurochemical, and behavioral alterations to those observed in PD providing a useful experimental model for the study of this neurodegenerative disease.

The beneficial effect of salubrinal on neuroinflammation and neuronal loss in intranigral LPS-induced hemi-Parkinson disease model in rats

2022 ◽  
pp. 1-10
Author(s):  
Fatma Nihan Cankara ◽  
Meliha Sümeyye Kuş ◽  
Caner Günaydın ◽  
Sinan Şafak ◽  
Süleyman Sırrı Bilge ◽  
...  
Keyword(s):  
Beneficial Effect ◽  
Parkinson Disease ◽  
Disease Model ◽  
Neuronal Loss

scholarly journals Clinical Correlates of Action Tremor in Parkinson Disease

2001 ◽  
Vol 58 (10) ◽  
pp. 1630 ◽  
Author(s):  
Elan D. Louis ◽  
Gilberto Levy ◽  
Lucien J. Côte ◽  
Helen Mejia ◽  
Stanley Fahn ◽  
...  
Keyword(s):  
Parkinson Disease ◽  
Action Tremor ◽  
Clinical Correlates

scholarly journals Heat shock protein 60: an endogenous inducer of dopaminergic cell death in Parkinson disease

2014 ◽  
Vol 11 (1) ◽  
pp. 86 ◽  
Author(s):  
Carmen Noelker ◽  
Lydie Morel ◽  
Anke Osterloh ◽  
Daniel Alvarez-Fischer ◽  
Thomas Lescot ◽  
...  
Keyword(s):  
Cell Death ◽  
Heat Shock ◽  
Heat Shock Protein ◽  
Parkinson Disease ◽  
Heat Shock Protein 60 ◽  
Dopaminergic Cell

scholarly journals Understanding Dopaminergic Cell Death Pathways in Parkinson Disease

Neuron ◽  
2016 ◽  
Vol 90 (4) ◽  
pp. 675-691 ◽  
Author(s):  
Patrick P. Michel ◽  
Etienne C. Hirsch ◽  
Stéphane Hunot
Keyword(s):  
Cell Death ◽  
Parkinson Disease ◽  
Dopaminergic Cell ◽  
Cell Death Pathways

scholarly journals Association of Protein Phosphatase 1γ1 with Spinophilin Suppresses Phosphatase Activity in a Parkinson Disease Model

2008 ◽  
Vol 283 (21) ◽  
pp. 14286-14294 ◽  
Author(s):  
Abigail M. Brown ◽  
Anthony J. Baucum ◽  
Martha A. Bass ◽  
Roger J. Colbran
Keyword(s):  
Parkinson Disease ◽  
Phosphatase Activity ◽  
Protein Phosphatase ◽  
Disease Model

scholarly journals Locomotor effects of a low-frequency fire alarm on C57BL/6 male mice: a preliminary study

2017 ◽  
Vol 51 (6) ◽  
pp. 647-651 ◽  
Author(s):  
Jessica M Povroznik ◽  
Robert E Faith ◽  
Matthew J Kessler ◽  
Frank N Ali ◽  
James Kosik ◽  
...  
Keyword(s):  
Low Frequency ◽  
Valuable Insight ◽  
Male Mice ◽  
Behavioral Alterations ◽  
Behavioral Experiments ◽  
Fire Alarm ◽  
Negative Impacts ◽  
Acoustic Conditions ◽  
Research Facilities ◽  
The Impact

Maintaining appropriate acoustic conditions for animal welfare and data collection are crucial in biomedical research facilities. Negative impacts of disruptive sound are known and can include auditory damage, immune function changes, and behavioral alterations. One type of disruptive sound occurring in research facilities is that of fire alarms. To ameliorate this problem, many facilities have incorporated the use of low-frequency fire alarms that emit tones outside the rodent audible range. The impact of these devices has been assumed to be negligible. However, this has yet to be evaluated with controlled behavioral experiments. Thus, our objective was to investigate the impact of low-frequency fire alarm exposure on locomotor behavior in the open field, a test sensitive to acoustic stimuli disruption. Male mice were randomized to three alarm exposure groups (No-Alarm; Alarm-During; and Alarm-After) and placed in individual photobeam-activated locomotor chambers. The Alarm-During group displayed significantly reduced horizontal locomotion, with a trend towards reduced vertical locomotion. These data suggest that a low-frequency brief alarm tone can temporarily disrupt movement, a valuable insight should an alarm be deployed. Further, findings support close collaboration between researchers and institutional facility staff to ensure appropriate acoustic conditions are maintained, whenever possible, for research animals.

Impact of Ras activation on the neuronal protection: implication for a Parkinson disease model

2005 ◽  
Vol 2005 (Fall) ◽  
Author(s):  
Konstantin Kuteykin-Teplyakov ◽  
Eftychia Sacharidou ◽  
Dirk Wolters ◽  
Ilya Toropygin ◽  
Rolf Heumann
Keyword(s):  
Parkinson Disease ◽  
Disease Model ◽  
Neuronal Protection ◽  
Ras Activation

scholarly journals Inhibitory Effects ofCoptidis rhizomaand Berberine on Cocaine-Induced Sensitization

2009 ◽  
Vol 6 (1) ◽  
pp. 85-90 ◽  
Author(s):  
Bombi Lee ◽  
Chae Ha Yang ◽  
Dae-Hyun Hahm ◽  
Eun Sang Choe ◽  
Hye-Jung Lee ◽  
...  
Keyword(s):  
Locomotor Activity ◽  
Daily Injection ◽  
Inhibitory Effects ◽  
Behavioral Alterations ◽  
Main Compound ◽  
Dopaminergic Systems ◽  
Dopamine Content ◽  
Cocaine Hydrochloride ◽  
The Central Nervous System ◽  
Neuronal Functions

Substantial evidence suggests that the behavioral and reinforcing effects of cocaine can be mediated by the central dopaminergic systems. Repeated injections of cocaine produce an increase in locomotor activity and the expression of tyrosine hydroxylase (TH) in the main dopaminergic areas. Protoberberine alkaloids affect neuronal functions.Coptidis rhizoma(CR) and its main compound, berberine (BER) reduced the dopamine content in the central nervous system. In order to investigate the effects of CR or BER on the repeated cocaine-induced neuronal and behavioral alterations, we examined the influence of CR or BER on the repeated cocaine-induced locomotor activity and the expression of TH in the brain by using immunohistochemistry. Male SD rats were given repeated injections of saline or cocaine hydrochloride (15 mg/kg, i.p. for 10 consecutive days) followed by one challenge injection on the 4th day after the last daily injection. Cocaine challenge (15 mg/kg, i.p) produced a larger increase in locomotor activity and expression of TH in the central dopaminergic areas. Pretreatment with CR (50, 100, 200 and 400 mg/kg, p.o.) and BER (200 mg/kg, p.o.) 30 min before the daily injections of cocaine significantly inhibited the cocaine-induced locomotor activity as well as TH expression in the central dopaminergic areas. Our data demonstrate that the inhibitory effects of CR and BER on the repeated cocaine-induced locomotor activity were closely associated with the reduction of dopamine biosynthesis and post-synaptic neuronal activity. These results suggest that CR and BER may be effective for inhibiting the behavioral effects of cocaine by possibly modulating the central dopaminergic system.

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