scholarly journals Eupafolin Suppresses P/Q-Type Ca2+ Channels to Inhibit Ca2+/ Calmodulin-Dependent Protein Kinase II and Glutamate Release at Rat Cerebrocortical Nerve Terminals

2021 ◽  
Author(s):  
Anna Chang ◽  
Chi-Feng Hung ◽  
Pei-Wen Hsieh ◽  
Horng-Huey Ko ◽  
Su-Jane Wang
Keyword(s):  
Protein Kinase ◽  
Glutamate Release ◽  
Nerve Terminals ◽  
Dependent Protein Kinase ◽  
Protein Kinase Ii ◽  
Dependent Protein ◽  
Ca2 Channels

scholarly journals A novel mechanism for Ca2+/calmodulin-dependent protein kinase II targeting to L-type Ca2+channels that initiates long-range signaling to the nucleus

2017 ◽  
Vol 292 (42) ◽  
pp. 17324-17336 ◽  
Author(s):  
Xiaohan Wang ◽  
Christian R. Marks ◽  
Tyler L. Perfitt ◽  
Terunaga Nakagawa ◽  
Amy Lee ◽  
...  
Keyword(s):  
Protein Kinase ◽  
Long Range ◽  
Dependent Protein Kinase ◽  
Protein Kinase Ii ◽  
Dependent Protein ◽  
Ca2 Channels

Ca(2+)-dependent activation of T-type Ca2+ channels by calmodulin-dependent protein kinase II

1994 ◽  
Vol 267 (1) ◽  
pp. F183-F189 ◽  
Author(s):  
H. K. Lu ◽  
R. J. Fern ◽  
J. J. Nee ◽  
P. Q. Barrett
Keyword(s):  
Protein Kinase ◽  
Dependent Protein Kinase ◽  
Slow Kinetics ◽  
Protein Kinase Ii ◽  
Voltage Dependent ◽  
Dependent Protein ◽  
Low Threshold ◽  
Low Amplitude ◽  
Kinetics Of ◽  
Ca2 Channels

The T-type Ca2+ channel is unique among voltage-dependent Ca2+ channels in its low threshold for opening and its slow kinetics of deactivation. Here, we evaluate the importance of intracellular Ca2+ (Cai2+) in promoting low-threshold gating of T-type channels in adrenal glomerulosa cells. We observe that 390 nM to 1.27 microM Cai2+ enhances T-type current by shifting the voltage dependence of channel activation to more negative potentials. This Ca(2+)-induced shift is mediated by calmodulin-dependent protein kinase II (CaMKII), because it is abolished by inhibitors of CaMKII but not of protein kinase C and is subsequently restored by exogenous calmodulin. This Ca(2+)-induced reduction in gating threshold would render T-type Ca2+ channels uniquely suited to transduce depolarizing stimuli of low amplitude into a Ca2+ signal sufficient to support a physiological response.

scholarly journals Distinct Roles of CaM and Ca2+/CaM-Dependent Protein Kinase II in Ca2+-Dependent Facilitation and Inactivation of Cardiac L-Type Ca2+ Channels

2007 ◽  
Vol 57 (3) ◽  
pp. 167-173 ◽  
Author(s):  
Hong-Guang Nie ◽  
Li-Ying Hao ◽  
Jian-Jun Xu ◽  
Etsuko Minobe ◽  
Asako Kameyama ◽  
...  
Keyword(s):  
Protein Kinase ◽  
Dependent Protein Kinase ◽  
Protein Kinase Ii ◽  
Dependent Protein ◽  
Ca2 Channels

scholarly journals Ca2+-Dependent Facilitation of Cav1.3 Ca2+ Channels by Densin and Ca2+/Calmodulin-Dependent Protein Kinase II

2010 ◽  
Vol 30 (15) ◽  
pp. 5125-5135 ◽  
Author(s):  
M. A. Jenkins ◽  
C. J. Christel ◽  
Y. Jiao ◽  
S. Abiria ◽  
K. Y. Kim ◽  
...  
Keyword(s):  
Protein Kinase ◽  
Dependent Protein Kinase ◽  
Protein Kinase Ii ◽  
Dependent Protein ◽  
Ca2 Channels
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