Serum levels of advanced glycation end products in type II diabetic patients with acute cerebral infarction

Abstract Background The prevalence of diabetes reaches epidemic proportions, affecting the incidence of diabetic nephropathy (DN) and associated end-stage kidney disease (ESKD). Diabetes is the leading cause of ESKD since 30–40% of diabetic patients develop DN. Albuminuria and eGFR have been considered a surrogate outcome of chronic kidney disease, and the search for a biomarker that predicts progression to diabetic kidney disease is intense.Methods We analyzed the association of serum advanced glycation end-products (AGEs) index (AGI) with impaired kidney function in uncontrolled diabetic patients (type II, n = 130) with albuminuria ranging from (150 to 450 mg/day). The kidney biopsy specimens were also examined for the association of AGEs, particularly carboxymethyl lysine (CML) with kidney function. Further, we also assessed the effect of carboxymethyl lysine on glomerular injury and podocytopathy in experimental animals.Results We observed a strong correlation between AGI and impaired kidney function in miroalbuminuric patients with hyperglycemia. A significant association between CML levels and impaired kidney function was noticed. Administration of CML in mice showed heavy proteinuria and glomerular abnormalities. Reduced podocyte number observed in mice administered with CML could be attributed to the epithelial-mesenchymal transition (EMT) of podocytes. Conclusion Serum AGEs could be independently related to the podocyte injury vis-a-vis the risk of DN progression to ESKD in patients with microalbuminuria. AGEs or CML could be considered a prognostic marker to assess microalbuminuria progression to ESKD in diabetic patients.

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Association of dietary intake, medication and anthropometric indices with serum levels of advanced glycation end products, caspase-3, and matrix metalloproteinase-9 in diabetic patients

Journal of Diabetes & Metabolic Disorders ◽

10.1007/s40200-021-00803-5 ◽

2021 ◽

Author(s):

Elaheh Foroumandi ◽

Sorayya Kheirouri ◽

Rahmat Nosrati ◽

Ramin Ghodsi

Keyword(s):

Matrix Metalloproteinase ◽

Advanced Glycation End Products ◽

Caspase 3 ◽

Serum Levels ◽

Diabetic Patients ◽

Advanced Glycation ◽

Anthropometric Indices ◽

Glycation End Products ◽

End Products ◽

Metalloproteinase 9

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Serum Levels of Advanced Glycation End Products Are Associated with In-Stent Restenosis in Diabetic Patients

Yonsei Medical Journal ◽

10.3349/ymj.2005.46.1.78 ◽

2005 ◽

Vol 46 (1) ◽

pp. 78 ◽

Cited By ~ 16

Author(s):

Eui-Young Choi ◽

Hyuck Moon Kwon ◽

Chul-Woo Ahn ◽

Geun Taek Lee ◽

Boyoung Joung ◽

...

Keyword(s):

Advanced Glycation End Products ◽

Serum Levels ◽

Diabetic Patients ◽

Advanced Glycation ◽

Stent Restenosis ◽

Glycation End Products ◽

End Products ◽

In Stent Restenosis

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Effects of vitamin D supplementation on advanced glycation end products signaling pathway in T2DM patients: a randomized, placebo-controlled, double blind clinical trial

Diabetology & Metabolic Syndrome ◽

10.1186/s13098-019-0479-x ◽

2019 ◽

Vol 11 (1) ◽

Cited By ~ 4

Author(s):

Mahsa Omidian ◽

Mahmoud Djalali ◽

Mohammad Hassan Javanbakht ◽

Mohammad Reza Eshraghian ◽

Maryam Abshirini ◽

...

Keyword(s):

Vitamin D ◽

Advanced Glycation End Products ◽

Serum Levels ◽

Vitamin D Supplementation ◽

Diabetic Patients ◽

Advanced Glycation ◽

Tnf Α ◽

Study Results ◽

Glycation End Products ◽

End Products

Abstract Background Several researches have recommended vitamin D possible health benefits on diabetic complications development, but a few number of studies have been accomplished on the molecular and cellular mechanisms. Certain cellular pathways modification and also some transcription factors activation may protect cells from hyperglycemia condition induced damages. This study purpose was to determine the vitamin D supplementation effect on some key factors [advanced glycation end products (AGEs) signaling pathway] that were involved in the diabetic complications occurrence and progression for type-2 diabetes participants. Methodology 48 type-2 diabetic patients (T2DM) randomly divided into two groups (n = 24 per group), receiving: 100-µg vitamin D or placebo for 3 months. At this study beginning and the end, the receptor expression for advanced glycation end products (RAGE) and glyoxalase I (GLO1) enzyme from peripheral blood mononuclear cells (PBMCs) and AGEs and tumor necrosis factor-α (TNF-α) serum levels were measured by the use of real-time PCR and ELISA methods, respectively. Results This study results demonstrated that vitamin D supplementation could down-regulate RAGE mRNA [fold change = 0.72 in vitamin D vs. 0.95 in placebo) P = 0.001)]. In addition, no significant changes were observed for GLO1 enzyme expression (P = 0.06). This study results also indicated that vitamin D serum level significantly increased in vitamin D group (P < 0.001). Moreover, AGES and TNF-α serum levels significantly reduced in vitamin D group, but they were remained unchanged in the placebo group. Conclusion In conclusion, vascular complications are more frequent in diabetic patients, and vitamin D treatment may prevent or delay the complications onset in these patients by AGEs serum level and RAGE gene expression reducing. Trial registration NCT03008057. Registered December 2016

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Possible participation of advanced glycation end products in the pathogenesis of osteoporosis in diabetic patients

Medical Hypotheses ◽

10.1016/j.mehy.2005.07.017 ◽

2005 ◽

Vol 65 (6) ◽

pp. 1013-1015 ◽

Cited By ~ 63

Author(s):

S. Yamagishi ◽

K. Nakamura ◽

H. Inoue

Keyword(s):

Advanced Glycation End Products ◽

Diabetic Patients ◽

Advanced Glycation ◽

Glycation End Products ◽

End Products

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Serum levels of soluble receptor for advanced glycation end products are associated with restenosis after drug-eluting stent implantation for stable angina pectoris

Atherosclerosis ◽

10.1016/j.atherosclerosis.2015.04.1012 ◽

2015 ◽

Vol 241 (1) ◽

pp. e214

Author(s):

S. Byazrova ◽

S. Kozlov ◽

Z. Gabbasov ◽

V. Kukharchuk ◽

V. Masenko

Keyword(s):

Angina Pectoris ◽

Advanced Glycation End Products ◽

Serum Levels ◽

Drug Eluting Stent ◽

Soluble Receptor ◽

Advanced Glycation ◽

Stable Angina Pectoris ◽

Glycation End Products ◽

End Products ◽

Drug Eluting

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De Novo Hepatocellular Carcinoma in Hepatitis C-Related Cirrhosis: Are Advanced Glycation End Products a Key Driver?

Frontiers in Cellular and Infection Microbiology ◽

10.3389/fcimb.2021.662431 ◽

2021 ◽

Vol 11 ◽

Author(s):

Ahmed Abdel-Razik ◽

Walaa Shabana ◽

Ahmed Mohamed El Nakib ◽

Mostafa Abdelsalam ◽

Ahmed Abdelwahab ◽

...

Keyword(s):

Hepatocellular Carcinoma ◽

Regression Analysis ◽

Hepatitis C ◽

Advanced Glycation End Products ◽

Cox Regression ◽

Diabetic Patients ◽

Advanced Glycation ◽

Cox Regression Analysis ◽

Glycation End Products ◽

End Products

Background and PurposeThe advanced glycation end products (AGEs) have been implicated in different diseases’ pathogenesis, but their role in hepatocellular carcinoma (HCC) is still a matter of debate. This study aims to investigate the association of AGEs with HCC development in patients with hepatitis C-related cirrhosis.MethodsOnly 153 of the 181 non-diabetic patients with cirrhosis were consecutively involved in this pilot cohort prospective study, along with 34 healthy control participants. Demographic characteristics, biochemical parameters, clinical data, and AGEs levels in all subjects at the starting point and every year after that for two years were assessed. Multivariable Cox regression analysis was used to settle variables that could predict HCC development within this period.ResultsHCC developed in 13 (8.5%) patients. Univariate Cox regression analysis reported that body mass index (P=0.013), homeostatic model assessment-insulin resistance (P=0.006), alpha-fetoprotein (P <0.001), and AGEs levels (P <0.001) were related to HCC development. After adjusting multiple confounders, the multivariable Cox regression model has revealed that AFP and AGEs were the powerful parameters related to the HCC occurrence (all P<0.05). AGEs at a cutoff value of more than 79.6 ng/ml had 100% sensitivity, 96.4% specificity, and 0.999 area under the curve (all P<0.001), using the receiver operating characteristic curve, for prediction of HCC development.ConclusionThis work suggests that AGEs are associated with an increased incidence of HCC, particularly in cirrhosis, which is encouraging in decreasing the risk of HCC in these patients.

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Relationship Between Advanced Glycation End Products and Their Receptor, sRAGE and Cardiovascular Diseases Risk in Adults with T2D and Vitamin D Insufficiency/deficiency (FS12-08-19)

Current Developments in Nutrition ◽

10.1093/cdn/nzz049.fs12-08-19 ◽

2019 ◽

Vol 3 (Supplement_1) ◽

Author(s):

Justina Owusu ◽

Fatma Huffman ◽

Juan Liuzzi ◽

Tan Li ◽

Vijaya Narayanan

Keyword(s):

Blood Pressure ◽

Vitamin D ◽

Cardiovascular Diseases ◽

Advanced Glycation End Products ◽

Serum Levels ◽

Vitamin D Insufficiency ◽

Advanced Glycation ◽

Glycation End Products ◽

End Products ◽

The Relationship

Abstract Objectives Advanced Glycation End Products, (AGEs) and their soluble receptor (sRAGE) have been implicated in the development of complications and mortality among individuals with type 2 diabetes (T2D). There is limited information on the relationship between AGEs and sRAGE and risk of cardiovascular diseases (CVD) in minority groups, who have a higher burden of T2D. The relationship between AGEs and sRAGE and CVD risks in adults with T2D and vitamin D insufficiency/deficiency was assessed in a minority population. Methods A cross sectional study of Hispanics and African Americans with T2D (n = 64, 41 women and 23 men, mean age = 54 ± 9) recruited from two clinics in Miami Dade. Systolic (SBP) and diastolic blood pressure (DBP), weight and height measurement and serum lipid profile were completed. ELISA kits were used to assess serum levels of AGEs (Biotang Inc/TSZ Elisa, Waltham, MA, USA) and sRAGE (Biotang Inc/TSZ Elisa, Waltham, MA, USA). Multiple linear regression was used to assess association between AGEs, sRAGE and CVD risks. Results A negative and significant association between AGEs and high-density lipoprotein cholesterol (HDL-C)(B = −0.551, P = 0.029) was found. The relationship between AGEs and HDL-C persisted after adjusting for covariates (P < 0.05). sRAGE was significantly associated with SBP (B = 0.015, P = 0.025) and diastolic blood pressure DBP (B = 0.0271, P = 0.037). Results loss significance when association between sRAGE and DBP and SBP were adjusted for covariates such as age, body mass index (BMI), smoking and alcohol intake. Conclusions Our results suggest that AGEs and sRAGE are related to markers of cardiovascular risk such as HDL-C, SBP and DBP in the study population of African Americans and Hispanics with T2D and vitamin D insufficiency/deficiency. Measures on reducing serum levels of AGEs and improving sRAGE and vitamin D are warranted in these populations for risk reduction of CVD. Funding Sources Partial funding for this research was provided through an NIH/NIDDK sponsored grant.

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