scholarly journals The role of red blood cell scintigraphy in the multiple-modality imaging diagnosis of a rare case of diffuse hepatic hemangiomatosis in an adult

2013 ◽  
pp. 194-198
Author(s):  
Ernesto Cason ◽  
Giorgio Treglia ◽  
Paolo Orlandi ◽  
Giorgio Fagioli
Keyword(s):  
Rare Case ◽  
Single Photon ◽  
Abdominal Mass ◽  
Photon Emission ◽  
Emission Computed Tomography ◽  
Imaging Diagnosis ◽  
Mri Findings ◽  
Abdominal Ultrasonography ◽  
Primary Tumors ◽  
Multiple Modality

Introduction: Angiomas are one of the most common primary tumors of the liver. Diffuse hepatic angiomatosis, however, is quite rare and usually observed in pediatric patients. We report a rare case of diffuse hepatic hemangiomatosis in a 33-year-old woman. Case report: The patient presented with abdominal pain and a palpable upper abdominal mass. Abdominal CT and magnetic resonance imaging (MRI) findings suggested diffuse hepatic hemangiomatosis, but this finding was not confirmed by subsequent contrast-enhanced abdominal ultrasonography (US). The patient then underwent single photon emission computed tomography (SPECT)/CT scintigraphy with Tc-99m-labeling of red blood cells (RBC). This examination revealed increased uptake of labeled erythrocytes in several of the hepatic lesions corresponding to CT and RM findings, thereby confirming the clinical hypothesis of diffuse hepatic hemangiomatosis. Discussion: RBC scintigraphy with SPECT/CT can facilitate the comparison of other crosssectional imaging methods such as CT and MRI. This case highlights the importance of a multiple-modality approach in the imaging diagnosis of this condition.

Diagnostic Efficiency of Single-Photon Emission Computed Tomography with 99MTc-MIBI in Visualization of Malignant Tumors of the Larynx and Laryngopharynx

2015 ◽  
Vol 1084 ◽  
pp. 373-376 ◽  
Author(s):  
Roman Zelchan ◽  
Vladimir Chernov ◽  
Anna Titskaya ◽  
Ivan Sinilkin ◽  
Svetlana Chizhevskaya ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Single Photon ◽  
Photon Emission ◽  
Emission Computed Tomography ◽  
Diagnostic Efficiency ◽  
Single Photon Emission ◽  
Primary Tumors ◽  
Emission Computed ◽  
Single Photon Emission Computed ◽  
Photon Emission Computed Tomography

To study the diagnostic efficiency of single-photon emission computed tomography (SPECT) with 99mTc-MIBI 40 patients were chosen for diagnosing primary and recurrence of laryngeal or laryngopharyngeal cancer and as well as patients with benign diseases of the larynx. All patients underwent SPECT with 99mTc-MIBI. As a result it has been found that the sensitivity, specificity and accuracy of SPECT with 99mTc-MIBI in the diagnostics of primary tumors of the larynx are 95%, 80% and 92%, respectively. The visualization of recurrent tumors of the larynx and laryngopharynx has showed 100% sensitivity. The obtained results have proved the consistency of SPECT with 99mTc-MIBI as an additional method of diagnostics of <em>laryngeal and laryngopharyngeal</em> cancer.

Detection of Recurrent Nasopharyngeal Carcinomas with Technetium-99m Methoxyisobutylisonitrile Single Photon Emission Computed Tomography in Patients with Indeterminate Magnetic Resonance Imaging Findings after Radiotherapy

2003 ◽  
Vol 112 (5) ◽  
pp. 415-418 ◽  
Author(s):  
Ming H. Tsai ◽  
Cheng C. Lin ◽  
Yu C. Shiau ◽  
Cheng C. Lee ◽  
Chih J. Tai ◽  
...  
Keyword(s):  
Single Photon ◽  
Photon Emission ◽  
Emission Computed Tomography ◽  
Resonance Imaging ◽  
Single Photon Emission ◽  
Mri Findings ◽  
Single Photon Emission Computed ◽  
Photon Emission Computed Tomography ◽  
Technetium 99M Methoxyisobutylisonitrile ◽  
Mibi Spect

The aim of this study was to evaluate the effectiveness of technetium-99m methoxyisobutylisonitrile (Tc-99m MIBI) single photon emission computed tomography (SPECT) for detecting recurrent nasopharyngeal carcinomas (NPCs) when magnetic resonance imaging (MRI) findings are indeterminate. Twenty-eight NPC patients who had received radiotherapy and had indeterminate MRI findings were included in the study. We performed MRI, Tc-99m MIBI SPECT, and biopsy at least 4 months after radiotherapy and within 1 week. The final results were based on histopathologic findings and clinical follow-up after 6 or more months. For detecting recurrent NPC in indeterminate MRI findings, the sensitivity, specificity, and accuracy of Tc-99m MIBI SPECT were 85.7%, 92.9%, and 89.3%, respectively. Our findings suggest that Tc-99m MIBI SPECT may be an effective tool for detecting recurrent NPC when MRI findings are indeterminate.

scholarly journals A Rare Case of Solitary Parathyroid Adenoma presenting with Recurrent Pancreatitis detected by Dual-phase Single-isotope Imaging (Technetium Sestamibi and Technetium Thyroid Scan) with SPECT-CT

2016 ◽  
Vol 8 (2) ◽  
pp. 175-178
Author(s):  
Amit Sharma ◽  
Arun R John ◽  
Anurag Jain ◽  
Madan G Vishnoi ◽  
Dharmesh Paliwal ◽  
...  
Keyword(s):  
Primary Hyperparathyroidism ◽  
Parathyroid Adenoma ◽  
Rare Case ◽  
Single Photon ◽  
Photon Emission ◽  
Emission Computed Tomography ◽  
Dual Phase ◽  
Recurrent Pancreatitis ◽  
Imaging Protocol ◽  
Thyroid Scan

ABSTRACT Primary hyperparathyroidism is a rare cause of acute pancreatitis with a rather uncommon association according to existing literature. We present a rare case of recurrent pancreatitis with primary hyperparathyroidism resulting from a solitary parathyroid adenoma detected by a dual-phase singleisotope imaging protocol using technetium pertechnetate and technetium sestamibi followed by a single-photon emission computed tomography (SPECT)-CT. The case demonstrates the requirement of a high index of suspicion of primary hyperparathyroidism as one of the etiologies in patients presenting with recurrent pancreatitis. This case highlights the role of dualphase single-isotope imaging (technetium pertechnetate and technetium sestamibi scan) along with SPECT-CT for precise anatomical localization of a parathyroid adenoma, which is of paramount importance to the surgeon for meticulous planning and execution of the surgical procedure. How to cite this article John AR, Jain A, Vishnoi MG, Paliwal D, Sharma A, Kumar N, Dubey IP. A Rare Case of Solitary Parathyroid Adenoma presenting with Recurrent Pancreatitis detected by Dual-phase Single-isotope Imaging (Technetium Sestamibi and Technetium Thyroid Scan) with SPECT-CT. World J Endoc Surg 2016;8(2):175-178.

scholarly journals Antibody-Targeted Imaging of Gastric Cancer

Molecules ◽  
2020 ◽  
Vol 25 (20) ◽  
pp. 4621 ◽  
Author(s):  
Komal Mandleywala ◽  
Shayla Shmuel ◽  
Patricia M. R. Pereira ◽  
Jason S. Lewis
Keyword(s):  
Gastric Cancer ◽  
Fluorescent Dyes ◽  
Tumor Imaging ◽  
Single Photon ◽  
Photon Emission ◽  
Whole Body ◽  
Emission Computed Tomography ◽  
Primary Tumors ◽  
Disease Response ◽  
Positron Emission

The specificity of antibodies for antigens overexpressed or uniquely expressed in tumor cells makes them ideal candidates in the development of bioconjugates for tumor imaging. Molecular imaging can aid clinicians in the diagnosis of gastric tumors and in selecting patients for therapies targeting receptors with a heterogeneous intratumoral or intertumoral expression. Antibodies labeled with an imaging radiometal can be used to detect primary tumors and metastases using whole-body positron emission tomography (PET) or single photon emission computed tomography (SPECT), both during diagnosis and monitoring disease response. Conjugated with fluorescent dyes, antibodies can image tumors by targeted optical imaging. This review provides an overview of the most recent advances in the use of antibodies labeled with radiometals or conjugated with fluorescent dyes for gastric cancer imaging.

scholarly journals False-negative 123I-MIBG SPECT is most commonly found in SDHB-related pheochromocytoma or paraganglioma with high frequency to develop metastatic disease

2011 ◽  
Vol 19 (1) ◽  
pp. 83-93 ◽  
Author(s):  
Jay S Fonte ◽  
Jeremyjones F Robles ◽  
Clara C Chen ◽  
James Reynolds ◽  
Millie Whatley ◽  
...  
Keyword(s):  
Metastatic Disease ◽  
Single Photon ◽  
False Negative ◽  
Photon Emission ◽  
Emission Computed Tomography ◽  
Tumor Diameter ◽  
Metastatic Tumors ◽  
Primary Tumors ◽  
Photon Emission Computed Tomography

The purpose of this study was to present the characteristics and outcome of patients with proven pheochromocytoma or paraganglioma who had false-negative iodine-123 metaiodobenzylguanidine single photon emission computed tomography (123I-MIBG SPECT). Twenty-one patients with false-negative 123I-MIBG SPECT (7 males, 14 females), aged 13–55 years (mean: 41.40 years), were included. We classified them as nonmetastatic or metastatic according to the stage of the disease at the time of false-negative 123I-MIBG SPECT study, the location and size of the tumor, plasma and urinary catecholamine and metanephrine levels, genetic mutations, and outcome in terms of occurrence and progression of metastases and death. Thirteen patients were evaluated for metastatic tumors, while the remaining eight were seen for nonmetastatic disease. All primary tumors and multiple metastatic foci did not show avid 123I-MIBG uptake regardless of the tumor diameter. The majority of patients had extraadrenal tumors with hypersecretion of normetanephrine or norepinephrine. SDHB mutations were present in 52% (n=11) of cases, RET mutation in 4% (n=1), and the rest were apparently sporadic. Twenty-four percent (n=5) had metastatic disease on initial presentation. Fourteen patients were followed for 3–7 years. Of them, 71% (n=10) had metastatic disease and the majority had SDHB mutations. Nine are still alive, while five (four with SDHB) died due to metastatic disease. We concluded that false-negative 123I-MIBG SPECT is frequently related to metastatic tumors and usually due to SDHB mutations with unfavorable prognosis. We therefore recommend that patients with false-negative 123I-MIBG SPECT be tested for SDHB mutations and undergo more regular and close follow-up.

Correlation of magnetic resonance imaging findings with hexamethylpropyleneamine oxime brain single photon emission computed tomography in ischemic stroke patients in the subacute stage

2006 ◽  
Vol 47 (4) ◽  
pp. 401-407 ◽  
Author(s):  
D. Kireşi ◽  
G. Taştekin ◽  
Ş. L. Cengiz ◽  
M. E. Üstün ◽  
B. Yürüten
Keyword(s):  
Single Photon ◽  
Photon Emission ◽  
Emission Computed Tomography ◽  
Mri Findings ◽  
Ischemic Lesion ◽  
Hmpao Spect ◽  
Perfusion Defects ◽  
T1 And T2 ◽  
Photon Emission Computed Tomography ◽  
T2 Weighted Images

Purpose: To evaluate the correlation between magnetic resonance imaging (MRI) findings and 99mTc-hexamethylpropyleneamine oxime (HMPAO) brain single photon emission computed tomography (SPECT) during the subacute stage in ischemic stroke patients. Material and Methods: The T1 and T2-weighted images and brain SPECT findings of 84 patients (mean age 60.69±12.47 years) with subacute cerebral ischemia during the period 1998–2004 were reviewed. All HMPAO SPECT and MRI studies were performed between 3 and 7 days (mean time delay 4.76±1.29 days) after the onset of stroke symptoms. Results: An ischemic lesion was seen both in T1 and T2-weighted images with perfusion defects above 60% (severe defect) according to count/pixel data of the lesion in HMPAO SPECT studies in 30 (90.9%) of 33 patients. Otherwise, the ischemic lesion was seen only on T2-weighted images with perfusion defects between 30% and 60% (moderate defect) in HMPAO SPECT studies in 25 (89.3%) of 28 patients. In 20 (87%) of 23 patients who had perfusion defects below 30% (mild defect) on HMPAO SPECT, only non-specific findings such as cerebral atrophy and/or periventricular ischemic-gliotic lesions could be seen in MRI. The difference between these ratios was statistically significant ( P<0.01). Conclusion: Brain 99mTc-HMPAO SPECT findings indicate good correlation with MRI findings. When the ischemic lesions could be seen in both T1 and T2-weighted images, the patients frequently had severe perfusion defects. When only seen in T2-weighted images, the perfusion defect was moderate. When only non-specific findings were revealed by MRI, only mild perfusion defects were found by SPECT.

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