scholarly journals Invasive pulmonary aspergillosis in a COVID-19 recovered patient: unravelling an infective sequalae of the SARS-CoV-2 virus

2021 ◽  
Vol 91 (2) ◽  
Author(s):  
Benhur Joel Shadrach ◽  
Rishabh Goel ◽  
Kunal Deokar ◽  
Anukool Jain
Keyword(s):  
Intensive Care Unit ◽  
Intensive Care ◽  
Emergency Room ◽  
Lung Disease ◽  
Invasive Pulmonary Aspergillosis ◽  
Morbidly Obese ◽  
Pulmonary Aspergillosis ◽  
The Past

Dear Editor, A 55-year-female, house wife, non-smoker, morbidly obese (BMI>35) with no other co-morbidities or pre-existing lung disease presented to the emergency room with complaints of highgrade fever, cough with minimal sputum, progressive breathlessness, streaky haemoptysis, and anorexia for the past 5 days. She was admitted in intensive care unit (ICU) for severe COVID-19 pneumonia three months back and had successfully recovered after 24 days of hospitalization....

scholarly journals A novel diagnosis scoring model to predict invasive pulmonary aspergillosis in the intensive care unit

2019 ◽  
Vol 40 (2) ◽  
pp. 140-146 ◽  
Author(s):  
Anna Rozaliyani ◽  
Rudyanto Sedono ◽  
Anwar Jusuf ◽  
Cleopas Rumende ◽  
Wahju Aniwidyaningsih ◽  
...  
Keyword(s):  
Intensive Care Unit ◽  
Intensive Care ◽  
Invasive Pulmonary Aspergillosis ◽  
Pulmonary Aspergillosis ◽  
Scoring Model

Invasive Pulmonary Aspergillosis in Patients With Severe Fever With Thrombocytopenia Syndrome

2019 ◽  
Author(s):  
Seongman Bae ◽  
Hye Jeon Hwang ◽  
Mi Young Kim ◽  
Min Jae Kim ◽  
Yong Pil Chong ◽  
...  
Keyword(s):  
Intensive Care Unit ◽  
Intensive Care ◽  
Antifungal Therapy ◽  
Invasive Pulmonary Aspergillosis ◽  
Pulmonary Aspergillosis ◽  
Severe Fever

Abstract Sixteen of 45 patients with severe fever with thrombocytopenia (36%) were admitted to an intensive care unit; 9 (56%) developed invasive pulmonary aspergillosis (IPA) within a median of 8 days (range, 2–11). Mortality was higher in the IPA vs non-IPA patients and in those without vs with antifungal therapy.

scholarly journals Risk factors for invasive aspergillosis in ICU patients with COVID-19: current insights and new key elements

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
G. Montrucchio ◽  
T. Lupia ◽  
D. Lombardo ◽  
G. Stroffolini ◽  
S. Corcione ◽  
...  
Keyword(s):  
Risk Factors ◽  
Intensive Care Unit ◽  
Intensive Care ◽  
Influenza Infection ◽  
Invasive Pulmonary Aspergillosis ◽  
Diagnostic Category ◽  
Pulmonary Aspergillosis ◽  
Related Factors ◽  
Epidemiological Characteristics ◽  
The Impact

AbstractInvasive pulmonary aspergillosis (IPA) has always been a challenging diagnosis and risk factors an important guide to investigate specific population, especially in Intensive Care Unit. Traditionally recognized risk factors for IPA have been haematological diseases or condition associated with severe immunosuppression, lately completed by chronic conditions (such as obstructive pulmonary disease, liver cirrhosis, chronic kidney disease and diabetes), influenza infection and Intensive Care Unit (ICU) admission. Recently, a new association with SARS-CoV2 infection, named COVID-19-associated pulmonary aspergillosis (CAPA), has been reported worldwide, even if its basic epidemiological characteristics have not been completely established yet. In this narrative review, we aimed to explore the potential risk factors for the development of CAPA and to evaluate whether previous host factors or therapeutic approaches used in the treatment of COVID-19 critically ill patients (such as mechanical ventilation, intensive care management, corticosteroids, broad-spectrum antibiotics, immunomodulatory agents) may impact this new diagnostic category. Reviewing all English-language articles published from December 2019 to December 2020, we identified 21 papers describing risk factors, concerning host comorbidities, ICU management, and COVID-19 therapies. Although limited by the quality of the available literature, data seem to confirm the role of previous host risk factors, especially respiratory diseases. However, the attention is shifting from patients’ related risk factors to factors characterizing the hospital and intensive care course, deeply influenced by specific features of COVID treatment itself. Prolonged invasive or non-invasive respiratory support, as well as the impact of corticosteroids and/or immunobiological therapies seem to play a pivotal role. ICU setting related factors, such as environmental factors, isolation conditions, ventilation systems, building renovation works, and temporal spread with respect to pandemic waves, need to be considered. Large, prospective studies based on new risk factors specific for CAPA are warranted to guide surveillance and decision of when and how to treat this particular population.

scholarly journals Pulmonary aspergillosis in two COVID-19 patients from Kuwait

2021 ◽  
Vol 3 (3) ◽  
Author(s):  
Khaled Alobaid ◽  
Beena Yousuf ◽  
Eman Al-Qattan ◽  
Zainab Muqeem ◽  
Nawaf Al-Subaie
Keyword(s):  
Intensive Care Unit ◽  
Intensive Care ◽  
Pulmonary Infection ◽  
Antifungal Agents ◽  
Negative Impact ◽  
Invasive Pulmonary Aspergillosis ◽  
Clinical Manifestations ◽  
Radiological Findings ◽  
Pulmonary Aspergillosis ◽  
Radiological Images

Critically ill patients with coronavirus disease 2019 (COVID-19) are at risk of invasive pulmonary aspergillosis. The clinical manifestations of a superimposed fungal infection in those patients are difficult to underpin. This is compounded by the non-specific radiological findings associated with this infection and the challenges associated with performing bronchoscopy in COVID-19 patients. We would like to present two COVID-19 cases who developed secondary Aspergillus pulmonary infection in the intensive care unit as shown by respiratory cultures, serum galactomannan and radiological images. Despite advanced intensive care and use of antifungal agents, both patients died eventually. This report illustrates the negative impact of secondary Aspergillosis and calls for the need of increased awareness of COVID19-associated pulmonary aspergillosis.

scholarly journals Invasive Pulmonary Aspergillosis in the Intensive Care Unit: A Case Report

2016 ◽  
Vol 14 (1) ◽  
pp. 43-46
Author(s):  
Mehmet Akif Yazar ◽  
Aytuna Kuzucuoğlu ◽  
Mehmet Barış Açıkgöz
Keyword(s):  
Intensive Care Unit ◽  
Intensive Care ◽  
Case Report ◽  
Invasive Pulmonary Aspergillosis ◽  
Pulmonary Aspergillosis

scholarly journals Influenza- and COVID-19-Associated Pulmonary Aspergillosis: Are the Pictures Different?

2021 ◽  
Vol 7 (5) ◽  
pp. 388
Author(s):  
Florian Reizine ◽  
Kieran Pinceaux ◽  
Mathieu Lederlin ◽  
Brice Autier ◽  
Hélène Guegan ◽  
...  
Keyword(s):  
Intensive Care Unit ◽  
Acute Respiratory Distress Syndrome ◽  
Intensive Care ◽  
Retrospective Study ◽  
Distress Syndrome ◽  
Invasive Pulmonary Aspergillosis ◽  
Radiological Findings ◽  
Pulmonary Aspergillosis ◽  
Invasive Fungal Diseases ◽  
Kaplan Meier

Invasive pulmonary aspergillosis (IPA) in intensive care unit patients is a major concern. Influenza-associated acute respiratory distress syndrome (ARDS) and severe COVID-19 patients are both at risk of developing invasive fungal diseases. We used the new international definitions of influenza-associated pulmonary aspergillosis (IAPA) and COVID-19-associated pulmonary aspergillosis (CAPA) to compare the demographic, clinical, biological, and radiological aspects of IAPA and CAPA in a monocentric retrospective study. A total of 120 patients were included, 71 with influenza and 49 with COVID-19-associated ARDS. Among them, 27 fulfilled the newly published criteria of IPA: 17/71 IAPA (23.9%) and 10/49 CAPA (20.4%). Kaplan–Meier curves showed significantly higher 90-day mortality for IPA patients overall (p = 0.032), whereas mortality did not differ between CAPA and IAPA patients. Radiological findings showed differences between IAPA and CAPA, with a higher proportion of features suggestive of IPA during IAPA. Lastly, a wide proportion of IPA patients had low plasma voriconazole concentrations with a higher delay to reach concentrations > 2 mg/L in CAPA vs. IAPA patients (p = 0.045). Severe COVID-19 and influenza patients appeared very similar in terms of prevalence of IPA and outcome. The dramatic consequences on the patients’ prognosis emphasize the need for a better awareness in these particular populations.

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