Relevance of the 5-HTTLPR Polymorphism and Childhood Abuse to Increased Psychiatric Comorbidity in Women With Bulimia-Spectrum Disorders

AbstractCompulsive sexual behavior (CSB) is characterized by inappropriate or excessive sexual behaviors or cognitions that lead to subjective distress or impaired functioning. Both abnormal (paraphilic) and conventional (nonparaphilic) forms of sexual behavior are usually included in the definition. CSB is reported to affect 3% to 6% of the general population in the United States, occurring more frequently in men. It typically begins in the late teens or early twenties and is chronic or intermittent. The disorder has been described as a progression through four stages: preoccupation, ritualization, gratification, and despair. Men with CSB typically focus on physical sexual gratification; women focus on romantic or emotional aspects of sexuality. Psychiatric comorbidity is common, particularly substance use, mood, anxiety, and personality disorders. CSB can lead to medical complications. Risk factors are thought to include family history and childhood abuse.

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Parental Perspectives on Psychiatric Comorbidity in Preschoolers With Autism Spectrum Disorders Receiving Publicly Funded Mental Health Services

Frontiers in Psychiatry ◽

10.3389/fpsyt.2019.00107 ◽

2019 ◽

Vol 10 ◽

Author(s):

Filippo Muratori ◽

Marco Turi ◽

Margherita Prosperi ◽

Antonio Narzisi ◽

Giovanni Valeri ◽

...

Keyword(s):

Mental Health ◽

Autism Spectrum Disorders ◽

Mental Health Services ◽

Health Services ◽

Psychiatric Comorbidity ◽

Autism Spectrum ◽

Publicly Funded ◽

Parental Perspectives ◽

Spectrum Disorders

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Dopamine-system genes, childhood abuse, and clinical manifestations in women with Bulimia-spectrum Disorders

Journal of Psychiatric Research ◽

10.1016/j.jpsychires.2012.05.018 ◽

2012 ◽

Vol 46 (9) ◽

pp. 1139-1145 ◽

Cited By ~ 23

Author(s):

Patricia Groleau ◽

Howard Steiger ◽

Ridha Joober ◽

Kenneth R. Bruce ◽

Mimi Israel ◽

...

Keyword(s):

Childhood Abuse ◽

Clinical Manifestations ◽

Dopamine System ◽

Spectrum Disorders

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Clinical features, developmental course, and psychiatric comorbidity of adult autism spectrum disorders

CNS Spectrums ◽

10.1017/s1092852913000941 ◽

2013 ◽

Vol 19 (2) ◽

pp. 157-164 ◽

Cited By ~ 41

Author(s):

Giulia Vannucchi ◽

Gabriele Masi ◽

Cristina Toni ◽

Liliana Dell'Osso ◽

Donatella Marazziti ◽

...

Keyword(s):

Autism Spectrum Disorders ◽

Clinical Picture ◽

Psychiatric Comorbidity ◽

Developmental Trajectories ◽

Autism Spectrum ◽

Course Development ◽

Obsessive Compulsive ◽

Adult Autism ◽

Spectrum Disorders ◽

The Relationship

Autism spectrum disorders (ASDs) include a heterogeneous group of neurodevelopmental disorders with early onset in childhood. ASDs should be considered lifelong clinical entities, although there is a certain variability in developmental trajectories, and therefore should be considered of great interest also for adulthood psychiatrists. A few studies have been carried out to explore the clinical picture and course development of these disorders during adulthood, or their relationship with other mental disorders. Indeed, ASDs often share overlapping features with other disorders, such as schizophrenia and obsessive-compulsive, mood, and personality disorders, and as a result misdiagnoses often occur. The aim of this review is to summarize the available literature on ASDs in adulthood with a specific focus on the clinical picture, course, and psychiatric comorbidity. It is proposed that a careful diagnostic screening for ASDs in adults would contribute to clarifying the relationship with comorbid psychiatric disorders, while improving the possibility of treatment and outcome of such conditions.

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