Neurocognitive deficits and history of childhood abuse in schizophrenia spectrum disorders: associations with Cluster B personality traits

2004 ◽  
Vol 68 (1) ◽  
pp. 87-94 ◽  
Author(s):  
P Lysaker
Keyword(s):  
Personality Traits ◽  
Childhood Abuse ◽  
Schizophrenia Spectrum Disorders ◽  
Neurocognitive Deficits ◽  
History Of Childhood ◽  
Schizophrenia Spectrum ◽  
History Of ◽  
Spectrum Disorders

scholarly journals The impact of schizotypy on pragmatics

2020 ◽  
Vol 62 ◽  
pp. e020014
Author(s):  
Monica de Freitas Frias Chaves ◽  
Cilene Rodrigues
Keyword(s):  
Personality Traits ◽  
Contextual Information ◽  
Brazilian Portuguese ◽  
Schizophrenia Spectrum Disorders ◽  
Semantic Meaning ◽  
General Hypothesis ◽  
Schizotypal Personality ◽  
Schizophrenia Spectrum ◽  
Spectrum Disorders ◽  
The Impact

High levels of linguistic referential failures are associated with liability to develop schizophrenia-spectrum disorders, and it has been shown that these failures can differentiate healthy subjects, high-schizotypal and schizophrenics groups. Nevertheless, few investigations have focused on whether or not schizotypal traits in nonclinical populations can also impact linguistic reference. In Brazilian Portuguese, only one previous study (acceptability judgements task) had been conducted, and its results suggest association between schizotypal traits and a more rigid preference for assignment of specific readings to definite singular DPs. Here, we present another experimental study in Brazilian Portuguese,  a comprehension task designed to examine possible effects of schizotypal personality traits on the interpretation of definite singular DPs. The findings, in line with the previous results, support the conclusion that schizotypy does affect the interpretation of definite singular DPs in Brazilian Portuguese. Together, these two experiments suggest that schizotypal personality traits impact the integration of linguistic contextual information into the semantic meaning of definite DPs. This is  consistent with the general hypothesis that schizotypy, similarly to schizophrenia, is associated with pragmatic difficulties. Yet, our results emphasize that the impact of schizotypal traits on pragmatics can be observed even in healthy (nonclinical) speakers.

scholarly journals Clinical correlates of the NR3C1 gene methylation at various stages of psychosis

2020 ◽  
Author(s):  
Błażej Misiak ◽  
Jerzy Samochowiec ◽  
Anna Konopka ◽  
Bożena Gawrońska-Szklarz ◽  
Jan Aleksander Beszłej ◽  
...  
Keyword(s):  
Clinical Population ◽  
First Episode ◽  
Schizophrenia Spectrum Disorders ◽  
Childhood Experiences ◽  
Immediate Memory ◽  
Schizophrenia Spectrum ◽  
Adverse Childhood ◽  
General Functioning ◽  
History Of ◽  
Spectrum Disorders

Abstract Background Dysregulation of epigenetic processes might account for alterations of the hypothalamic-pituitary-adrenal axis observed in patients with schizophrenia. Therefore, in this study, we aimed to investigate methylation of the glucocorticoid receptor (NR3C1) gene in patients with schizophrenia-spectrum disorders, individuals at familial high risk of schizophrenia (FHR-P) and healthy controls (HCs) with respect to clinical manifestation and a history of psychosocial stressors. Methods We recruited 40 first-episode psychosis (FEP) patients, 45 acutely relapsed schizophrenia (SCZ-AR) patients, 39 FHR-P individuals and 56 HCs. The level of methylation at nine CpG sites of the NR3C1 gene was determined using pyrosequencing. Results The level of NR3C1 methylation was significantly lower in FEP patients and significantly higher in SCZ-AR patients compared to other subgroups of participants. Individuals with FHR-P and HCs had similar levels of NR3C1 methylation. A history of adverse childhood experiences (ACEs) was associated with significantly lower NR3C1 methylation in all subgroups of participants. Higher methylation of the NR3C1 gene was related to worse performance of attention and immediate memory as well as lower level of general functioning in patients with psychosis. Conclusions Patients with schizophrenia-spectrum disorders show altered levels of NR3C1 methylation that is significantly lower in FEP patients and significantly higher in SCZ-AR patients. Higher methylation of the NR3C1 gene might be related to cognitive impairment observed in this clinical population. The association between a history of ACEs and lower NR3C1 methylation is not specific to patients with psychosis. Longitudinal studies are needed to establish causal mechanisms underlying these observations.

scholarly journals Neurocognition and social cognition in patients with schizophrenia spectrum disorders with and without a history of violence: results of a multinational European study

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Laura Iozzino ◽  
Philip D. Harvey ◽  
Nicola Canessa ◽  
Pawel Gosek ◽  
Janusz Heitzman ◽  
...  
Keyword(s):  
Social Cognition ◽  
Cognitive Skills ◽  
Population Data ◽  
Clinical Population ◽  
Schizophrenia Spectrum Disorders ◽  
Forensic Patients ◽  
Schizophrenia Spectrum ◽  
History Of ◽  
History Of Violence ◽  
Spectrum Disorders

Abstract Objective Neurocognitive impairment has been extensively studied in people with schizophrenia spectrum disorders and seems to be one of the major determinants of functional outcome in this clinical population. Data exploring the link between neuropsychological deficits and the risk of violence in schizophrenia has been more inconsistent. In this study, we analyse the differential predictive potential of neurocognition and social cognition to discriminate patients with schizophrenia spectrum disorders with and without a history of severe violence. Methods Overall, 398 (221 cases and 177 controls) patients were recruited in forensic and general psychiatric settings across five European countries and assessed using a standardized battery. Results Education and processing speed were the strongest discriminators between forensic and non-forensic patients, followed by emotion recognition. In particular, increased accuracy for anger recognition was the most distinctive feature of the forensic group. Conclusions These results may have important clinical implications, suggesting potential enhancements of the assessment and treatment of patients with schizophrenia spectrum disorders with a history of violence, who may benefit from consideration of socio-cognitive skills commonly neglected in ordinary clinical practice.

scholarly journals A multinational case−control study comparing forensic and non-forensic patients with schizophrenia spectrum disorders: the EU-VIORMED project

2021 ◽  
pp. 1-11
Author(s):  
Giovanni de Girolamo ◽  
Laura Iozzino ◽  
Clarissa Ferrari ◽  
Pawel Gosek ◽  
Janusz Heitzman ◽  
...  
Keyword(s):  
Personality Disorder ◽  
Interpersonal Violence ◽  
Case Control Study ◽  
Case Control ◽  
Schizophrenia Spectrum Disorders ◽  
Forensic Patients ◽  
Schizophrenia Spectrum ◽  
History Of ◽  
Spectrum Disorders ◽  
Control Study

Abstract Background The relationship between schizophrenia and violence is complex. The aim of this multicentre case–control study was to examine and compare the characteristics of a group of forensic psychiatric patients with a schizophrenia spectrum disorders and a history of significant interpersonal violence to a group of patients with the same diagnosis but no lifetime history of interpersonal violence. Method Overall, 398 patients (221 forensic and 177 non-forensic patients) were recruited across five European Countries (Italy, Germany, Poland, Austria and the United Kingdom) and assessed using a multidimensional standardised process. Results The most common primary diagnosis in both groups was schizophrenia (76.4%), but forensic patients more often met criteria for a comorbid personality disorder, almost always antisocial personality disorder (49.1 v. 0%). The forensic patients reported lower levels of disability and better social functioning. Forensic patients were more likely to have been exposed to severe violence in childhood. Education was a protective factor against future violence as well as higher levels of disability, lower social functioning and poorer performances in cognitive processing speed tasks, perhaps as proxy markers of the negative syndrome of schizophrenia. Forensic patients were typically already known to services and in treatment at the time of their index offence, but often poorly compliant. Conclusions This study highlights the need for general services to stratify patients under their care for established violence risk factors, to monitor patients for poor compliance and to intervene promptly in order to prevent severe violent incidents in the most clinically vulnerable.

scholarly journals Understanding the Influence of Personality Traits on Risk of Suicidal Behaviour in Schizophrenia Spectrum Disorders: A Systematic Review

2021 ◽  
Vol 10 (19) ◽  
pp. 4604
Author(s):  
Manuel Canal-Rivero ◽  
Rosa Ayesa-Arriola ◽  
Esther Setién-Suero ◽  
Benedicto Crespo-Facorro ◽  
Celso Arango ◽  
...  
Keyword(s):  
Systematic Review ◽  
Personality Traits ◽  
Suicidal Behaviour ◽  
Selection Criteria ◽  
Schizophrenia Spectrum Disorders ◽  
Related Factors ◽  
Schizotypal Personality ◽  
Premature Deaths ◽  
Schizophrenia Spectrum ◽  
Spectrum Disorders

Risk of suicidal behaviour (SB) in schizophrenia spectrum disorders (SSD) is a major concern, particularly in early stages of the illness, when suicide accounts for a high number of premature deaths. Although some risk factors for SB in SSD are well understood, the extent to which personality traits may affect this risk remains unclear, which may have implications for prevention. We conducted a systematic review of previous studies indexed in MEDLINE, PsycINFO and Embase examining the relationship between personality traits and SB in samples of patients with SSD. Seven studies fulfilled predetermined selection criteria. Harm avoidance, passive-dependent, schizoid and schizotypal personality traits increased the risk of SB, while self-directedness, cooperativeness, excluding persistence and self-transcendence acted as protective factors. Although only seven studies were retrieved from three major databases after applying predetermined selection criteria, we found some evidence to support that personality issues may contribute to SB in patients with SSD. Personality traits may therefore become part of routine suicide risk assessment and interventions targeting these personality-related factors may contribute to prevention of SB in SSD.

Violent offending in schizophrenia spectrum disorders preceding and following diagnosis

2018 ◽  
Vol 52 (8) ◽  
pp. 782-792 ◽  
Author(s):  
Henning Hachtel ◽  
Cieran Harries ◽  
Stefan Luebbers ◽  
James RP Ogloff
Keyword(s):  
Mental Health ◽  
Risk Factors ◽  
Substance Use ◽  
Schizophrenia Spectrum Disorders ◽  
Violent Offending ◽  
Schizophrenia Spectrum ◽  
History Of ◽  
Spectrum Disorders ◽  
Violent Victimisation ◽  
Violent Offences

Objective: People affected by schizophrenia spectrum disorders are at a higher risk of offending violently. This study aims to investigate risk factors in relation to the peri-diagnostic period and possible predictors of post-diagnostic violence of people diagnosed for the first time in the public mental health system. Methods: The study compared various risk factors for post-diagnostic violence in patients ( n = 1453) diagnosed with a schizophrenia spectrum disorder. Patients were grouped according to the occurrence of peri-diagnostic violence. Of the 246 violent offenders, 164 committed their first offence pre-diagnosis. Mental health and criminological variables were evaluated across the lifespan (median age at end of follow-up = 34.22 years, range = 17.02–55.80 years). Results: Gender, employment, non-violent offending, family incidents, violent and non-violent victimisation, substance use, personality disorder, number of in-patient admissions and history of non-compliance differed significantly across violent and non-violent subgroups (all p ⩽ 0.01 and at least small effect size). More frequent and longer inpatient admissions were found in the violent subgroups (all p ⩽ 0.01). For the whole sample, sex, number of violent offences, non-violent offences, violent victimisation, substance use and number of inpatient admissions predicted post-diagnostic violence (χ2 (6) = 188.13, p < 0.001). Among patients with a history of pre-diagnostic violence, a history of non-violent offending in the 18-month period pre-diagnosis was the strongest predictor of future violence (odds ratio = 3.08, 95% confidence interval [1.32, 7.21]). Conclusion: At triage, violence risk assessment should consider the presence of antisocial behaviour and violent victimisation, substance use, male gender and frequency of inpatient admissions. Common treatment targets for the prevention of post-diagnostic violence include criminality and victimisation. Treatment of positive symptoms should be of greater emphasis for individuals without a history of pre-diagnostic violence.

Schizophrenia–schizoaffective–bipolar spectra: an epistemological perspective

CNS Spectrums ◽  
2019 ◽  
pp. 1-5
Author(s):  
João Gama Marques ◽  
Sílvia Ouakinin
Keyword(s):  
Personality Traits ◽  
Schizophrenia Spectrum Disorders ◽  
Epistemological Perspective ◽  
Schizophrenia Spectrum ◽  
Spectrum Disorders ◽  
Different Levels

AbstractFor decades clinicians and researchers have been thinking and writing about the spectrum of schizophrenia disorders. Indeed both Kraepelin and Bleuler believed in schizophrenia as a spectrum, both in a clinical (individual) and hereditary (family) continuum, from just some exquisite personality traits to unquestionable chronic and debilitating psychosis. Other authors would put the schizophrenia spectrum disorders on different levels of continuum: developmental, psychofunctional, existential, and genetic. Here, we would like to present an historical chronology for the schizophrenia–schizoaffective–bipolar spectra plus a tridimensional model for these spectra: the first axis for categories (affective versus nonaffective psychoses), the second axis for dimensions (personality versus full blown psychosis), and a third axis for biomarkers (remission versus relapse). We believe that without the schizophrenia–schizoaffective–bipolar spectra concept in our minds all our efforts will keep failing one the hardest quest: searching for biomarkers in schizophrenia and related disorders.

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